Results 81 to 90 of about 80,664 (276)

Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro

BMC Neuroscience, 2006
Background The striatal complex is the major target of dopamine action in the CNS. There, medium-spiny GABAergic neurons, which constitute about 95% of the neurons in the area, form a mutually inhibitory synaptic network that is modulated by dopamine ...
Joyce Myra P, Schulman Joshua J, Feldman Igor G, Norris J Madison, Geldwert Daron, Rayport Stephen   +5 more
doaj   +1 more source

Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens

Molecular Brain, 2022
Recent research has suggested that the mesolimbic dopamine network that mainly terminates in the nucleus accumbens may positively control the peripheral immune system.
Daisuke Sato, Yusuke Hamada, Michiko Narita, Tomohisa Mori, Hiroyuki Tezuka, Yukari Suda, Kenichi Tanaka, Sara Yoshida, Hideki Tamura, Akihiro Yamanaka, Emiko Senba, Naoko Kuzumaki, Minoru Narita   +12 more
doaj   +1 more source

Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]

, 2011
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A., Bohr, Colin, Figueroa-Guzman, Yazmin, Graf, Evan N., Li, Shi-Jiang, Mantsch, John R., Mueller, Christopher R, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +9 more
core   +2 more sources

Plasma Membrane Compartmentalization of D2 Dopamine Receptors [PDF]

Journal of Biological Chemistry, 2013
Plasma membrane microcompartments could allow different signaling pathways to operate more efficiently and prevent cross-talk. We utilized a novel in-cell biotin transfer assay to demonstrate that the majority of plasma membrane-expressed D2 dopamine receptor (D2R) is microcompartmentalized within detergent-resistant structures.
Sharma, Meenakshi, Celver, Jeremy, Octeau, J. Christopher, Kovoor, Abraham   +3 more
openaire   +3 more sources

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

Movement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori, Stefano Zucca, Colten K. Lankford, Yi‐Zhi Wang, Marianna Franco, Nina A. Alekseeva, Sevinj Ahmedova, Han My Van, Jeffrey N. Savas, Kirill A. Martemyanov   +9 more
wiley   +1 more source

Dichotomous Dopaminergic Control of Ventral Pallidum Neurons

Frontiers in Cellular Neuroscience, 2018
The ventral pallidum (VP) is crucially involved in reward processing. Dopaminergic afferents reach the VP from the ventral tegmental area (VTA). Recent in vivo studies suggest dopamine application increase the firing in the VP.
Martin Clark, Enrico Bracci
doaj   +1 more source

L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction [PDF]

, 2012
Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine ...
Mantsch, John R., Wang​, Jia Bei
core   +1 more source

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]

, 2019
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E., da Silva e Silva, Daniel, Dobbs, Lauren K., Kolb, Vanessa, Luderman, Kathryn D., Rubinstein, Marcelo, Shashikiran, Sannidhi, Sibley, David R., Álvarez, Verónica Alicia   +8 more
core   +1 more source

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Movement Disorders, EarlyView.
D2 receptor ablation in indirect‐pathway striatal neurons reduces or abolishes dyskinetic and dystonic behaviors induced by L‐DOPA or D2 receptor agonists, respectively. Contralateral turning is reduced, while forward locomotion is increased. These effects are associated with modulation of neuronal activity in dorsal striatum and external globus ...
Laura Andreoli, Teodor Nyman, Elena Espa, Johan Jakobsson, Osama F. Elabi, Maria Angela Cenci   +5 more
wiley   +1 more source

Dopamine D2 receptor upregulation in dorsal striatum in the LRRK2-R1441C rat model of early Parkinson’s disease revealed by in vivo PET imaging

Scientific Reports
We conducted PET imaging with [18F]FDOPA and dopamine D2/3 receptor ligand [18F]fallypride in aged transgenic rats carrying human pathogenic LRRK2 R1441C or G2019S mutations.
Teresa Delgado-Goñi, Natalie Connor-Robson, Milena Cioroch, Stephen Paisey, Christopher Marshall, Emma L. Lane, David Hauton, James McCullagh, Peter J. Magill, Stephanie J. Cragg, Clare E. Mackay, Richard Wade-Martins, Johannes C. Klein   +12 more
doaj   +1 more source