Results 51 to 60 of about 147,933 (225)

PET Imaging of the Interaction between Adenosine A2A and Dopamine D2 Receptors in Animal Models of Brain Diseases [PDF]

, 2023
This thesis focuses on the antagonistic interactions between adenosine and dopamine in living mammals, mediated through adenosine A2A and dopamine D2 receptors. These interactions are crucial in locomotor activation, goal-directed behavior, motor control,
Prasad, Kavya
core   +1 more source

Reduced Insulin Sensitivity Is Related to Less Endogenous Dopamine at D2/3 Receptors in the Ventral Striatum of Healthy Nonobese Humans

International Journal of Neuropsychopharmacology, 2015
Background: Food addiction is a debated topic in neuroscience. Evidence suggests diabetes is related to reduced basal dopamine levels in the nucleus accumbens, similar to persons with drug addiction.
F. Caravaggio, C. Borlido, M. Hahn, Zhe Feng, G. Fervaha*, P. Gerretsen, S. Nakajima, E. Plitman, J. Chung, Y. Iwata, Alan A. Wilson, G. Remington, A. Graff-Guerrero   +12 more
semanticscholar   +1 more source

Voltage sensitivity of dopamine D2-like receptors [PDF]

, 2011
G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core   +1 more source

Abundance compensates kinetics : similar effect of dopamine signals on D1 and D2 receptor populations [PDF]

, 2020
The neuromodulator dopamine plays a key role in motivation, reward-related learning, and normal motor function. The different affinity of striatal D1 and D2 dopamine receptor types has been argued to constrain the D1 and D2 signaling pathways to phasic ...
Hunger, L., Kumar, A., Schmidt, R.
core   +1 more source

Fluorescent ligands for dopamine D2/D3 receptors [PDF]

Scientific Reports, 2020
AbstractFluorescent ligands are versatile tools for the study of G protein-coupled receptors. Depending on the fluorophore, they can be used for a range of different applications, including fluorescence microscopy and bioluminescence or fluorescence resonance energy transfer (BRET or FRET) assays.
Allikalt, Anni, Purkayastha, Nirupam, Flad, Khajidmaa, Schmidt, Maximilian F., Tabor, Alina, Gmeiner, Peter, Hübner, Harald, Weikert, Dorothee   +7 more
openaire   +4 more sources

Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation [PDF]

, 2010
The article presents the hypothesis that nigrostriatal dopamine may regulate movement by modulation of tone and contraction in skeletal muscles through a concentration-dependent influence on the postsynaptic D1 and D2 receptors on the follow manner ...
A Antonini, A Korchounov, A Parent, A Parent, AC McCreary, Alexei Korchounov, AM Lozano, B Bloch, B Voller, B Voller, C Asanuma, C Singer, CR Gerfen, CS Chaurasia, D Cunic, D King, D Rylander, D Shprecher, DE Oorschot, DF Wong, E Broussolle, E Lynd-Balta, E Ronken, EC Hirsch, ED Abercrombie, F Baldissera, F Coria, F Del Sorbo, F Hefti, F Meintzschel, FJ Vingerhoets, G Deuschl, G Di Chiara, G Percheron, G Percheron, G Stern, H Bernheimer, HB Niznik, HW Shin, IK Goerendt, J Bertran-Gonzalez, J Doyon, J Hore, J Massion, J Wardas, JA Obeso, JC Hedreen, JL Taylor, JR Walters, K Takakusaki, KA Jellinger, KJ Burchiel, KM Dewar, LN Hazrati, LR Albin, LV Laitinen, M Delfino, M Dogali, M Filion, M Gerlach, M Kato, M Pötter-Nerger, M Reimold, MB Knable, MD Bevan, MD Crutcher, MF Chesselet, Michael F. Meyer, Michael Krasnianski, MS Baron, NP Murphy, P Hoefer, P Piccini, P Valkovic, P Zheng, PI Johnson, PJ Blanchet, PJ Blanchet, PS Verhave, R Kristeva-Feige, R Spanagel, RK Schwarting, S Beck, S Callier, S Caudron, S Hattori, S Ramanathan, SC Sealfon, SM Hersch, SP Richardson, T Wichmann, TC Andrews, W Matsuda, W Schultz, Y Smith, YH Sohn   +95 more
core   +2 more sources

Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission

Scientific Reports, 2016
In addition to dopamine neuron firing, cholinergic interneurons (ChIs) regulate dopamine release in the striatum via presynaptic nicotinic receptors (nAChRs) on dopamine axon terminals.
Aphroditi A. Mamaligas, Yuan Cai, C. P. Ford   +2 more
semanticscholar   +1 more source

Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons

Biomedicines, 2021
α-synuclein accumulation into dopaminergic neurons is a pathological hallmark of Parkinson’s disease. We previously demonstrated that fatty acid-binding protein 3 (FABP3) is critical for α-synuclein uptake and propagation to accumulate in dopaminergic ...
Ichiro Kawahata, Tomoki Sekimori, Haoyang Wang, Yanyan Wang, Toshikuni Sasaoka, Luc Bousset, Ronald Melki, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga   +9 more
doaj   +1 more source

Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner

Experimental and Molecular Medicine, 2018
Pain medicine: why blocking dopamine receptors alleviates morphine tolerance By blocking dopamine receptors located in the spinal cord, a compound found in a traditional Chinese herbal medicine may help mitigate tolerance to morphine, a common problem ...
Wen-Ling Dai, Xin-Tong Liu, Yi-Ni Bao, Bing Yan, Nan Jiang, Bo-Yang Yu, Ji-Hua Liu   +6 more
doaj   +1 more source

Dopamine D1 + D3 receptor density may correlate with Parkinson disease clinical features [PDF]

, 2021
OBJECTIVE: Dopamine D2-like receptors - mainly dopamine D2 receptors (D2R) and dopamine D3 receptors (D3R) - are believed to be greatly involved in the pathology of Parkinson disease (PD) progression.
Benzinger, Tammie L S, Guo, Yingqiu, Knight, William C, Li, Huifangjie, Morris, John C, Perlmutter, Joel S, Xu, Jinbin, Yang, Pengfei   +7 more
core   +2 more sources