Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain
Translational Psychiatry, 2015 Caffeine, the most widely consumed psychoactive substance in the world, is used to promote wakefulness and enhance alertness. Like other wake-promoting drugs (stimulants and modafinil), caffeine enhances dopamine (DA) signaling in the brain, which it ...
N. Volkow +9 more
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Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. [PDF]
, 2018 gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and
Aguinaga Andrés, David +6 more
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Frontiers in Neuroscience, 2015 Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates.
Asher eHaug-Baltzell +8 more
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The effects of an adenosine A(2A) agonist as an adjunctive treatment to alleviate sensorimotor gating deficits in a rodent model of schizophrenia [PDF]
, 2020 The adenosine system has become a promising target for the treatment of schizophrenia due to its unique relationship with dopamine D2 receptors. Dopamine D2 receptors display heightened sensitivity in schizophrenia, and inhibition of these receptors has ...
Rauhuff, Hannah
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Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats [PDF]
The Iranian Journal of Veterinary Science and Technology, 2014 Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes.
Sima Nasri +4 more
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Dopamine elevates and lowers astroglial Ca(2+) through distinct pathways depending on local synaptic circuitry [PDF]
, 2016 Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca(2+) rises, the dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To minimize effects of experimental manipulations on astroglial physiology,
Bard, L +6 more
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BMC Neuroscience, 2007 Background In both schizophrenia and addiction, pathological changes in dopamine release appear to induce alterations in the circuitry of the nucleus accumbens that affect coordinated thought and motivation. Dopamine acts principally on medium-spiny GABA
Schmauss Claudia +2 more
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Amphetamine Promotes Cortical Up State in Part Via Dopamine Receptors
Frontiers in Pharmacology, 2021 Cortical neurons oscillate between Up and Down states during slow wave sleep and general anesthesia. Recent studies show that Up/Down oscillations also occur during quiet wakefulness.
Guofang Shen, Wei-Xing Shi, Wei-Xing Shi
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Journal of Neuroscience, 2012 Impulsive behavior is thought to reflect a traitlike characteristic that can have broad consequences for an individual's success and well-being, but its neurobiological basis remains elusive.
D. Ghahremani +11 more
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The role of intracerebral dopamine D1 and D2 receptors in sleep‐wake cycles and general anesthesia
Ibrain, 2022 Dopamine (DA), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (SN) pars compacta of the midbrain.
Jie Zhang +5 more
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