Results 61 to 70 of about 151,968 (306)

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core   +1 more source

SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding

Advanced Science, EarlyView.
SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui, Yong Zhao, Canqun Yang, Tao Tang, Xiangke Liao, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuansong Zeng   +8 more
wiley   +1 more source

Central interaction of ascorbic acid and D2 dopamine receptors on spatial learning and memory in adult male rats [PDF]

The Iranian Journal of Veterinary Science and Technology, 2014
Previous studies had reported that extracellular levels of ascorbic acid have modulatory effects on dopamine receptors. Both ascorbic acid and dopamine receptor have an important role in learning and memory processes.
Sima Nasri, Mehri Bahaaddini, mehdi abbasnejad, Saeed Esmaeili-Mahani, Ramin Raoof   +4 more
doaj   +1 more source

Amphetamine Promotes Cortical Up State in Part Via Dopamine Receptors

Frontiers in Pharmacology, 2021
Cortical neurons oscillate between Up and Down states during slow wave sleep and general anesthesia. Recent studies show that Up/Down oscillations also occur during quiet wakefulness.
Guofang Shen, Wei-Xing Shi, Wei-Xing Shi
doaj   +1 more source

Haloperidol Induced Orofacial Dyskinesia: Clinical Insights Into Buccolingual Masticatory Syndrome. [PDF]

Clin Case Rep
ABSTRACT Haloperidol and other antipsychotics can cause buccolingual masticatory syndrome (BLMS), a rare but serious extrapyramidal disorder characterized by involuntary movements of the cheeks, jaws, and tongue. The author describes a 40‐year‐old man presenting with retrograde lingual movements, chewing difficulties, and speech impairment after 2 ...
Bereda G.
europepmc   +2 more sources

Reduced GABA-B/GIRK-mediated regulation of the VTA following a single exposure to cocaine [PDF]

, 2012
In this paper, Arora and colleagues expand on their previous work on GIRK channels in the ventral tegmental area (VTA) presenting evidence that a single exposure to cocaine reduces inhibitory GABAergic transmission to dopamine (DA) neurons in the ventral
Andrew Varnell, Brian Cadle, Donald C. Cooper   +2 more
core   +2 more sources

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Distinct roles of presynaptic dopamine receptors in the differential modulation of the intrinsic synapses of medium-spiny neurons in the nucleus accumbens

BMC Neuroscience, 2007
Background In both schizophrenia and addiction, pathological changes in dopamine release appear to induce alterations in the circuitry of the nucleus accumbens that affect coordinated thought and motivation. Dopamine acts principally on medium-spiny GABA
Schmauss Claudia, Mizuno Takeo, Rayport Stephen   +2 more
doaj   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

Dissociable effects of dopamine on neuronal firing rate and synchrony in the dorsal striatum

Frontiers in Integrative Neuroscience, 2009
Previous studies showed that dopamine depletion leads to both changes in firing rate and in neuronal synchrony in the basal ganglia. Since dopamine D1 and D2 receptors are preferentially expressed in striatonigral and striatopallidal medium spiny neurons,
John M Burkhardt, John M Burkhardt, Xin Jin, Rui M Costa, Rui M Costa   +4 more
doaj   +1 more source