Results 1 to 10 of about 6,686,909 (365)

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity. [PDF]

Cells, 2020
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity.
Marx-Stoelting P, Knebel C, Braeuning A.
europepmc   +2 more sources

G protein-coupled receptors: structure- and function-based drug discovery

Signal Transduction and Targeted Therapy, 2021
As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design.
Dehua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yiran Wu, Elita Yuliantie, Linshan Xie, Houchao Tao, Jianjun Cheng, Qing Liu, Suwen Zhao, Wenqing Shui, Yi Jiang, Ming-Wei Wang   +14 more
doaj   +2 more sources

Lysophospholipid receptors in drug discovery [PDF]

Experimental Cell Research, 2015
Lysophospholipids (LPs), including lysophosphatidic acid (LPA), sphingosine 1-phospate (S1P), lysophosphatidylinositol (LPI), and lysophosphatidylserine (LysoPS), are bioactive lipids that transduce signals through their specific cell-surface G protein-coupled receptors, LPA1-6, S1P1-5, LPI1, and LysoPS1-3, respectively.
Yasuyuki Kihara, Jerold Chun, Hirotaka Mizuno   +2 more
openaire   +4 more sources

Proteomic Learning of Gamma-Aminobutyric Acid (GABA) Receptor-Mediated Anesthesia [PDF]

arXiv
Anesthetics are crucial in surgical procedures and therapeutic interventions, but they come with side effects and varying levels of effectiveness, calling for novel anesthetic agents that offer more precise and controllable effects. Targeting Gamma-aminobutyric acid (GABA) receptors, the primary inhibitory receptors in the central nervous system, could
Jiang J, Chen L, Zhu Y, Shi Y, Qiu H, Zhang B, Zhou T, Wei GW.   +7 more
arxiv   +2 more sources

P2X Receptors as Drug Targets [PDF]

Molecular Pharmacology, 2013
The study of P2X receptors has long been handicapped by a poverty of small-molecule tools that serve as selective agonists and antagonists. There has been progress, particularly in the past 10 years, as cell-based high-throughput screening methods were applied, together with large chemical libraries.
R. Alan North, Michael F. Jarvis
openaire   +4 more sources

Labels as a feature: Network homophily for systematically annotating human GPCR drug-target interactions [PDF]

Nature Communications
Machine learning has revolutionized drug discovery by enabling the exploration of vast, uncharted chemical spaces essential for discovering novel patentable drugs.
Frederik G. Hansson, Niklas Gesmar Madsen, Lea G. Hansen, Tadas Jakočiūnas, Bettina Lengger, Jay D. Keasling, Michael K. Jensen, Carlos G. Acevedo-Rocha, Emil D. Jensen   +8 more
doaj   +2 more sources

PEGylated exenatide injection (PB-119) improves beta-cell function and insulin resistance in treatment-naïve type 2 diabetes mellitus patients

Frontiers in Pharmacology, 2023
Objective: PB-119, a PEGylated exenatide injection, is a once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate the effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 ...
Xu Liu, Xu Liu, Xu Liu, Ling Song, Ling Song, Ling Song, Yuanhui Zhang, Haiyan Li, Haiyan Li, Haiyan Li, Cheng Cui, Cheng Cui, Cheng Cui, Dongyang Liu, Dongyang Liu, Dongyang Liu   +15 more
doaj   +1 more source

WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice

Discover Oncology, 2023
Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated.
Wanting Xue, Lihong Cai, Su Li, Yujia Hou, Yan-Dong Wang, Dongbin Yang, Yubing Xia, Xiaobo Nie   +7 more
doaj   +1 more source

Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease

Frontiers in Pharmacology, 2022
The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries ...
Yajie Fu, Yanzhi Zhou, Linhu Shen, Xuewen Li, Haorui Zhang, Yeqi Cui, Ke Zhang, Weiguo Li, Wei-dong Chen, Wei-dong Chen, Shizhen Zhao, Yunfu Li, Wenling Ye   +12 more
doaj   +1 more source

Role of G-protein coupled receptors in cardiovascular diseases

Frontiers in Cardiovascular Medicine, 2023
Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li, Boyu Li, Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang   +4 more
doaj   +1 more source