Results 1 to 10 of about 696,648 (168)
Frontiers in Pharmacology, 2023 Objective: PB-119, a PEGylated exenatide injection, is a once-weekly glucagon-like peptide-1 receptor agonist. In the present study, we aimed to evaluate the effects of PB-119 on insulin resistance and beta-cell function in Chinese patients with type 2 ...
Xu Liu +15 more
doaj +1 more source
WNT ligands in non-small cell lung cancer: from pathogenesis to clinical practice
Discover Oncology, 2023 Non-small cell lung cancer (NSCLC) is the malignant tumor with the highest morbidity and leading cause of death worldwide, whereas its pathogenesis has not been fully elucidated.
Wanting Xue +7 more
doaj +1 more source
Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease
Frontiers in Pharmacology, 2022 The global incidence rate of non-alcoholic fatty liver disease (NAFLD) is approximately 25%. With the global increase in obesity and its associated metabolic syndromes, NAFLD has become an important cause of chronic liver disease in many countries ...
Yajie Fu +12 more
doaj +1 more source
Role of G-protein coupled receptors in cardiovascular diseases
Frontiers in Cardiovascular Medicine, 2023 Cardiovascular diseases (CVDs) are the leading cause of death globally, with CVDs accounting for nearly 30% of deaths worldwide each year. G-protein-coupled receptors (GPCRs) are the most prominent family of receptors on the cell surface, and play an ...
Yuanqiang Li +4 more
doaj +1 more source
Emerging Roles of Wnt Ligands in Human Colorectal Cancer
Frontiers in Oncology, 2020 Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and constitutive activation of the Wnt signaling pathway is universal in most CRC cases.
Xiaobo Nie +5 more
doaj +1 more source
The Apelin/APJ System in Psychosis and Neuropathy
Frontiers in Pharmacology, 2020 Apelin, an endogenous neuropeptide, has been identified as the cognate ligand for the G-protein-coupled receptor APJ. Apelin, APJ messenger RNA, and protein are widely expressed in the central nervous system and peripheral tissues of humans and animals ...
Shuang-Yu Lv +3 more
doaj +1 more source
Frontiers in Pharmacology, 2019 The aberrant expression of Wnt3 has linked to several types of human malignancies. However, it is not known for its role in tumorigenesis of colorectal cancer (CRC).
Xiaobo Nie +13 more
doaj +1 more source
Emerging Roles of NPQ/Spexin in Physiology and Pathology
Frontiers in Pharmacology, 2019 Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide. Spexin gene and protein are widely expressed in central nervous system and peripheral tissues in humans, rodents, goldfish, etc.
Shuang-Yu Lv +5 more
doaj +1 more source
The Role of the Apelin/APJ System in the Regulation of Liver Disease
Frontiers in Pharmacology, 2017 Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues.
Wei-Dong Chen +4 more
doaj +1 more source
eLife, 2020 By analyzing and simulating inactive conformations of the highly homologous dopamine D2 and D3 receptors (D2R and D3R), we find that eticlopride binds D2R in a pose very similar to that in the D3R/eticlopride structure but incompatible with the D2R ...
J Robert Lane +10 more
doaj +1 more source