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Activation of the Carotid Body by Kappa Opioid Receptors Mitigates Fentanyl-Induced Respiratory Depression. [PDF]
Function (Oxf)Peng YJ +5 more
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Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analysis. [PDF]
PLoS OneMahmud S +7 more
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Structural insights into the distinct ligand recognition and signaling of the chemerin receptors CMKLR1 and GPR1. [PDF]
Protein CellLin X +14 more
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Advances in receptor chromatography for drug discovery and drug–receptor interaction studies
Drug Discovery Today, 2023Receptor chromatography involves high-throughput separation and accurate drug screening based on specific drug-receptor recognition and affinity, which has been widely used to screen active compounds in complex samples. This review summarizes the immobilization methods for receptors from three aspects: random covalent immobilization methods, site ...
Jia Fu +4 more
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Gastrointestinal Drug Receptors
Journal of Clinical Gastroenterology, 1983Drug receptors consist of recognition sites coupled to transducer and cellular amplifier mechanisms. Slight differences in receptor recognition sites can be exploited pharmacologically to provide drugs with a high degree of selectivity for activating or blocking individual receptor subtypes.
Thomas F. Burks +2 more
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Current Protocols in Pharmacology, 2006
AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael Williams, Rita Raddatz
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AbstractReceptors, located on both the cell surface and within the cell, are the molecular targets through which drugs produce their beneficial effects in various disease states. Receptors were initially conceptualized at the beginning of the 20th century by the parallel efforts of Ehrlich and Langley.
Michael Williams, Rita Raddatz
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The emergence of the drug receptor theory [PDF]
Nature Reviews Drug Discovery, 2002 Today, the concept of specific receptors for drugs and transmitters lies at the very heart of pharmacology. Less than one hundred years ago, this novel idea met with considerable resistance in the scientific community. To mark the 150th anniversary of the birth of John Newport Langley, one of the founders of the receptor concept, we highlight his most ...
Andreas-Holger Maehle +2 more
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Drug Receptors and their Function
Nature, 1971There have been various theories about the way in which drugs exert their effects. If recent progress in the isolation of receptors continues, it should soon be possible to look directly at the interaction between drugs and tissues.
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