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2020
Conventional treatment of any disease can be achieved by the administration of drugs of natural and synthetic origin. The drug exhibits its pharmacological action by altering cellular signaling or the biochemical events associated with the respective target proteins such as receptors or enzymes.
Haneen Al-Joubi +10 more
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Conventional treatment of any disease can be achieved by the administration of drugs of natural and synthetic origin. The drug exhibits its pharmacological action by altering cellular signaling or the biochemical events associated with the respective target proteins such as receptors or enzymes.
Haneen Al-Joubi +10 more
openaire +2 more sources
1978
It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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It is commonly accepted today that drugs, hormones, or other small molecules that gain access to biological systems bring about their effects by interacting with macromolecules present in the biological system. These macromolecules can then be assigned the term “receptor” for that particular small molecule.
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Challenges for receptor theory as a tool for drug and drug receptor classification
Trends in Pharmacological Sciences, 1989Increased understanding in the field of receptor pharmacology, born of the sophisticated techniques now available to us, has confounded rather than simplified the problem of receptor classification. The International Union of Pharmacology (IUPHAR) is currently sponsoring a Receptor Nomenclature Committee whose aims are to recommend a rational system of
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Interaction of muscarinic drugs with their receptor
General Pharmacology: The Vascular System, 1985Interaction of muscarinic drugs with their receptor was studied in the logitudinal muscle of guinea pig ileum. The pD2-value, the index for agonistic activity of a partial agonist was practically equal to its pA2-value, the index for competitive antagonistic activity and to its pKA-value which was a negative logarithm of a dissociation constant (KA ...
Issei Takayanagi +2 more
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Immunophilin Receptors for Immunosuppressive Drugs
Therapeutic Drug Monitoring, 1993The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP 12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature is reviewed on some possible mechanisms
Yajun Chen +4 more
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Drugs affecting serotonin receptors
Baillière's Clinical Gastroenterology, 1994A greater understanding of the various serotonin receptor subtypes has led to a clearer appreciation of the role of serotonin in gastrointestinal motility, sensation and secretion. Serotonin is definitely involved in the aetiopathogenesis of cisplatin-induced emesis and carcinoid diarrhoea. The application of serotonergic drugs in clinical therapeutics
Manfred R. Von Der Ohe +1 more
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Drug interactions at GABAA receptors
Progress in Neurobiology, 2002Neurotransmitter receptor systems have been the focus of intensive pharmacological research for more than 20 years for basic and applied scientific reasons, but only recently has there been a better understanding of their key features. One of these systems includes the type A receptor for the gamma-aminobutyric acid (GABA), which forms an integral ...
Esa R. Korpi +2 more
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1965
Publisher Summary This chapter reviews that the concept of a receptor proves to be remarkably elusive, considering the central position it occupies in the theory of pharmacology. A receptor is considered as the component of a cell with which a drug combines to initiate a response. It is suggested that the receptor has a complementary structure to the
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Publisher Summary This chapter reviews that the concept of a receptor proves to be remarkably elusive, considering the central position it occupies in the theory of pharmacology. A receptor is considered as the component of a cell with which a drug combines to initiate a response. It is suggested that the receptor has a complementary structure to the
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Nuclear receptor drug discovery
Current Opinion in Chemical Biology, 2008Nuclear receptors (NR) are ligand-activated transcription factors that regulate the activation of a variety of important target genes. There are 48 genes that encode NRs in the human genome, and these receptors now represent one of the most important targets for therapeutic drug development.
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Receptors, Neurotransmitters and Drug Responses
New England Journal of Medicine, 1979ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine.
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