Results 31 to 40 of about 6,519,345 (216)
Molecules, 2021 Membrane proteins such as G protein-coupled receptors (GPCRs) exert fundamental biological functions and are involved in a multitude of physiological responses, making these receptors ideal drug targets.
Yann Waltenspühl +3 more
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The Hippocampus Is the Place to Be: Opioid Receptors and LTP
Cell Reports, 2019 Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference.
Thomas M. Sanderson +3 more
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The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity
Frontiers in Immunology, 2021 The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu +43 more
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Japanese Journal of Pharmacology, 1964 In the study of the drug-receptor interaction, the analysis of the mode of drugantagonism had been the objects of the principal interests, and the drug-synergism had only been remarked in passing (1). Veldstra (2) mentioned the relation between drug receptor and synergism in his extensive review on “Synergism and Potentiation”.
K, TAKAGI, I, TAKAYANAGI
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Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients
BMC Medical Genetics, 2001 Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether
Choi Chul-Hee +3 more
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Kathmandu University Medical Journal, 2012 In present-day pharmacology and medicine, it is usually taken for granted that cells contain a host of highly specific receptors. Drugs act on the cell membrane by physical and/or chemical interactions. This is usually through specific drug receptor sites known to be located on the membrane. These are defined as proteins on or within the cell that bind
openaire +4 more sources
Repurposing of the Drug Tezosentan for Cancer Therapy
Current Issues in Molecular Biology, 2023 Tezosentan is a vasodilator drug that was originally developed to treat pulmonary arterial hypertension. It acts by inhibiting endothelin (ET) receptors, which are overexpressed in many types of cancer cells. Endothelin-1 (ET1) is a substance produced by
Eduarda Ribeiro, Nuno Vale
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Gray-Matter Volume, Midbrain Dopamine D2/D3 Receptors and Drug Craving in Methamphetamine Users
Molecular Psychiatry, 2015 Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in ...
M. Alda
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Drug Conjugates for Targeting Eph Receptors in Glioblastoma
Pharmaceuticals, 2020 Glioblastoma (GBM) is a complex and heterogeneous tumor that warrants a comprehensive therapeutic approach for treatment. Tumor-associated antigens offer an opportunity to selectively target various components of the GBM microenvironment while sparing ...
Puja Sharma +5 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors
British Journal of Pharmacology, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
Stephen P. H. Alexander +11 more
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