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Endothelin, endothelin receptors, and endothelin antagonists.
Current opinion in nephrology and hypertension, 1995Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor, ETC. In vascular smooth muscle cells, endothelin causes profound contraction and also has proliferative effects, mainly through activation of ETA but also through ETB ...
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1998
Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
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Since the original discovery of endothelin (ET) by Yanagisawa et al in 1988,1 the scientific interest in this area of research has grown exponentially. It was originally hypothesized that ET interacts with two subtypes of receptors to mediate its biological functions and subsequent cloning of two ET receptors confirmed the original hypothesis.
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[Endothelin receptor antagonist].
Nihon rinsho. Japanese journal of clinical medicine, 2009Pulmonary arterial hypertension(PAH) is an uncommon disease characterised by a progressive increase in pulmonary vascular resistance. An imbalance between vasoconstrictor/vasodilator activities could be responsible for altered pulmonary vascular tone and structure. In PAH patients, endothelin are increased.
Takuya, Kishi, Kenji, Sunagawa
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Evolution of the endothelin pathway drove neural crest cell diversification
Nature, 2020Tyler A Square +2 more
exaly
Endothelin 1 in cancer: biological implications and therapeutic opportunities
Nature Reviews Cancer, 2013Laura Rosanò +2 more
exaly