Results 21 to 30 of about 32,261 (224)

P10.01 INVOLVEMENT OF CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASE II ON ENDOTHELIN RECEPTOR EXPRESSION IN CEREBRAL ARTERIES OF RAT

Artery Research, 2009
Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent
R. Waldsee, H. Ahnstedt, S. Eftekhari, L. Edvinsson   +3 more
doaj   +1 more source

Endothelin-1 Role in Human Eye: A Review

Journal of Ophthalmology, 2010
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Serena Salvatore, Enzo Maria Vingolo
doaj   +1 more source

The role of endothelin-1 and its autoantibodies in the pathogenesisof atopic dermatitis: a case-control study

Vestnik Dermatologii i Venerologii, 2021
Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1.
Irina V. Kibalina, Namzhil N. Tsybikov
doaj   +1 more source

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

Cardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +3 more sources

Expression profile of endothelin receptors (ETA and ETB) and microRNAs-155 and -199 in the corpus cavernosum of rats submitted to chronic alcoholism and diabetes mellitus

Brazilian Journal of Medical and Biological Research, 2018
Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ...
F.Z. Gonçalves, F.S. Lizarte Neto, P.C. Novais, D. Gattas, L.G. Lourenço, C.A.M. de Carvalho, D.P.C. Tirapelli, C.A.F. Molina, L.F. Tirapelli, S. Tucci Jr   +9 more
doaj   +1 more source

Repurposing of the Drug Tezosentan for Cancer Therapy

Current Issues in Molecular Biology, 2023
Tezosentan is a vasodilator drug that was originally developed to treat pulmonary arterial hypertension. It acts by inhibiting endothelin (ET) receptors, which are overexpressed in many types of cancer cells. Endothelin-1 (ET1) is a substance produced by
Eduarda Ribeiro, Nuno Vale
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity

The Scientific World Journal, 2010
Cigarette smoke exposure is well known to cause cardiovascular and airway diseases, both of which are leading causes of death and disability in the world.
Yaping Zhang, Lars Edvinsson, Cang-Bao Xu   +2 more
doaj   +1 more source

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration

Frontiers in Physiology, 2020
BackgroundWhile chemerin has been shown to increase proliferation and migration of systemic vascular smooth muscle cells (SMCs) contributing therefore to the development of hypertension, this remains to be clarified for the pulmonary circulation ...
Aliénor Hanthazi, Pascale Jespers, Grégory Vegh, Christine Dubois, Géraldine Hubesch, Jean-Yves Springael, Laurence Dewachter, Kathleen Mc Entee   +7 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source