Results 21 to 30 of about 63,448 (267)

Attenuation of ischemic liver injury by monoclonal anti-endothelin antibody, awETN40 [PDF]

, 1997
Background: Enhanced production of endothelin-1 (ET1), vasoconstrictive 21 amino acids produced by endothelial cells during ischemia and after reperfusion of the liver, is known to cause sinusoidal constriction and microcirculatory disturbances, which ...
Ishizaki, N, Jin, MB, Lee, R, Shimamura, T, Starzl, TE, Subbotin, V, Todo, S, Totsuka, E, Urakami, A, Zhang, S, Zhu, Y   +10 more
core   +1 more source

Endothelin type A receptors mediate pain in a mouse model of sickle cell disease

Haematologica, 2018
Sickle cell disease is associated with acute painful episodes and chronic intractable pain. Endothelin-1, a known pain inducer, is elevated in the blood plasma of both sickle cell patients and mouse models of sickle cell disease.
Brianna Marie Lutz, Shaogen Wu, Xiyao Gu, Fidelis E. Atianjoh, Zhen Li, Brandon M. Fox, David M. Pollock, Yuan-Xiang Tao   +7 more
doaj   +1 more source

Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1 [PDF]

, 2004
The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater
Alabadí Ferrer, José Antonio, Alborch Domínguez, Enrique, González Marrachelli, Vannina Elena, Lloréns, Silvia, Miranda Alonso, Francisco Javier   +4 more
core   +2 more sources

Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist [PDF]

Cardiovascular Research, 1998
The vasoconstrictor effect of endothelins (ET) is mediated by endothelin A (ETA) and endothelin B (ETB) receptors. Furthermore, ETB receptor stimulation results in release of vasodilators. Hence, ETA receptor antagonists should attenuate ET-mediated vasoconstriction. The aim of the present study was to evaluate and compare the effects of BQ-123, an ETA
Zhang, Y., Oliver, J., Horowitz, J.
openaire   +4 more sources

Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]

, 1998
Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao, Simon, Melvin I., Wu, Dianqing, Xie, Wei, Yuan, Huidong   +4 more
core   +1 more source

Endothelin receptors in GtoPdb v.2023.1 [PDF]

, 2023
Endothelin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Endothelin Receptors [24]) are activated by the endogenous 21 amino-acid peptides endothelins 1-3 (endothelin-1, endothelin-2 and endothelin-3)
Abraham, George R., D'Orléans-Juste, Pedro, Davenport, Anthony P., Godfraind, Théophile, Maguire, Janet J., Ohlstein, Eliot H., Ruffolo, Robert R., Williams, Thomas L.   +7 more
core   +2 more sources

Expression of Endothelin-1, Endothelin Receptor-A, and Endothelin Receptor-B in facial melasma compared to adjacent skin

Clinical, Cosmetic and Investigational Dermatology, 2023
Although melasma is highly prevalent, its pathogenesis is not yet fully understood. In the skin, endothelin-1 (ET-1) is primarily produced by keratinocytes in response to UVB exposure, which is mediated by an increase in IL-1α or reactive oxygen species.
Carolina da Silva, Hélio Miot, Tony Fernando Grassi, Luciane Alarcão Dias-Melício, Leandro Santos, Ana Cláudia Cavalcante Espósito   +5 more
openaire   +3 more sources

Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways

BMC Cardiovascular Disorders, 2008
Background Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has therefore been suggested as a ...
Edvinsson Lars, Gesslein Bodil, Wackenfors Angelica, Gustafsson Lotta, Nilsson David, Paulsson Per, Ingemansson Richard, Malmsjö Malin   +7 more
doaj   +1 more source

Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes [PDF]

, 2006
The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries
Alabadí Ferrer, José Antonio, Alborch Domínguez, Enrique, González Marrachelli, Vannina Elena, Lloréns, Silvia, Miranda Alonso, Francisco Javier   +4 more
core   +2 more sources

EndothelinA-endothelinB receptor cross-talk and endothelin receptor binding [PDF]

Journal of Pharmacy and Pharmacology, 2011
Abstract Background and objective The magnitude of inhibition of an endothelin (ET)-1 response by selective blockade of the ETA or ETB receptors can be limited by apparent compensation mediated by the unblocked receptor.
Mario Zuccarello, Robert M. Rapoport
openaire   +3 more sources