Results 101 to 110 of about 577,108 (265)

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

The Cellular Biology of Erythropoietin Receptors

The Oncologist, 2003
Abstract Learning Objectives After completing this course, the reader will be able to: Explain the structure and functions of erythropoietin. Distinguish the multiple activities of erythropoietin in the human body. Recognize the potential role of erythropoietin receptors in targeting
openaire   +2 more sources

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach

BMC Bioinformatics, 2009
Background The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is one of the most important targets for myeloproliferative disorder (MPD).
Lee Eunjung, Park Inho, Won Hong-Hee, Kim Jong-Won, Lee Doheon   +4 more
doaj   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Evidence that erythropoietin modulates neuroinflammation through differential action on neurons, astrocytes, and microglia

Frontiers in Immunology, 2014
Neuroinflammation is a normal and healthy response to neuronal damage. However, excessive or chronic neuroinflammation exacerbates neurodegeneration after trauma and in progressive diseases such as Alzheimer’s, Parkinson’s, age-related macular ...
Wesley S Bond, Tonia S Rex
doaj   +1 more source

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain

Acta Neuropathologica, 2001
Using immunohistochemistry, expression of erythropoietin (EPO), a hypoxia-inducible neuroprotective factor, and its receptor (EPOR) were investigated in human brain tissue after ischemia/hypoxia. Autopsy brains of neuropathologically normal subjects were compared to those with ischemic infarcts or hypoxic damage.
Siren, A. L., Knerlich, F., Poser, Wolfgang, Gleiter, Christoph H., Bruck, Wolfgang W., Ehrenreich, Hannelore   +5 more
openaire   +3 more sources

Divergence Linked to Possible Ecological Speciation in Blind Mole Rats: Integration of Thermal Biology and Bite Force in the Upper Galilee Blind Mole Rat (Nannospalax galili)

Integrative Zoology, EarlyView.
Basalt‐dwelling blind mole rats maintain lower body temperatures, show greater post‐digging thermal increases, and dig more efficiently than those from rendzina soils. Although metabolic rates and bite force did not differ between populations, these thermal and physiological shifts align with the greater mechanical resistance and seasonal hypoxia of ...
Matěj Lövy, Jan Okrouhlík, František Vejmělka, Pavlína Schwarzová, Maja Rendulić, Eviatar Nevo, Radim Šumbera   +6 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source