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Seminars in Oncology, 2001
Erythropoietin (EPO) is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. The EPO receptor belongs to the same family of receptors as growth hormone, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, and some interleukins.
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Erythropoietin (EPO) is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. The EPO receptor belongs to the same family of receptors as growth hormone, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, and some interleukins.
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Erythropoietin Receptor Structural Domains
2017Erythropoietin (EPO) is a hormone that is important for regulating red blood cell production. It is functional through binding to its receptor-EpoR. EpoR is a single-span membrane protein. It contains an extracellular region, a transmembrane domain, and a C-terminus.
Qingxin, Li, CongBao, Kang
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1995
Abstract Epo receptors are detectable in binding experiments using 125I-epo. Primary erythroid progenitors in the yolk sac, fetal liver, bone marrow and spleen express small numbers of receptors, as do megakaryocytes (300-1000 per cell) (Youssoufian et al. 1993).
D J Hilton, S S Watowich
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Abstract Epo receptors are detectable in binding experiments using 125I-epo. Primary erythroid progenitors in the yolk sac, fetal liver, bone marrow and spleen express small numbers of receptors, as do megakaryocytes (300-1000 per cell) (Youssoufian et al. 1993).
D J Hilton, S S Watowich
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Immunolocalization of Erythropoietin and Erythropoietin Receptor in Vestibular Schwannoma
Acta Oto-Laryngologica, 2001Vestibular schwannomas constitute approximately 6% of intracranial tumors. Apart from the association with neurofibromatosis-2 (NF-2), where a defect in chromosome 22 has been identified, the pathogenesis of sporadic vestibular schwannomas is largely unknown.
D G, Dillard +5 more
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Carbamylated erythropoietin increases frataxin independent from the erythropoietin receptor
European Journal of Clinical Investigation, 2010Eur J Clin Invest 2010; 40 (6): 561–565AbstractBackground Friedreich’s ataxia (FRDA) is a neurodegenerative disorder caused by decreased expression of the mitochondrial protein frataxin. Recently we showed in a clinical pilot study in Friedreich’s ataxia patients that recombinant human erythropoietin (rhuEPO) significantly increases frataxin ...
Brigitte, Sturm +5 more
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The human erythropoietin receptor
The International Journal of Cell Cloning, 1992Molecular analysis of the human erythropoietin receptor (EpoR) promises to yield a greater mechanistic understanding of erythropoiesis and disease states that affect red cell production. The cloned receptor molecule is a 66 kDa membrane protein that is structurally related to a large superfamily of haemopoietin/growth factor receptors.
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 1988
A membrane receptor for erythropoietin was identified in various erythropoietin-unresponsive mouse erythroleukemia cells. Scatchard analyses of the binding of human 125I-labeled erythropoietin to T3C1-2-0, K-1, GM86 and 707 cells showed the presence of a single class of binding sites with apparent Kd values of 0.27-0.78 nM, which are slightly higher ...
K, Todokoro +3 more
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A membrane receptor for erythropoietin was identified in various erythropoietin-unresponsive mouse erythroleukemia cells. Scatchard analyses of the binding of human 125I-labeled erythropoietin to T3C1-2-0, K-1, GM86 and 707 cells showed the presence of a single class of binding sites with apparent Kd values of 0.27-0.78 nM, which are slightly higher ...
K, Todokoro +3 more
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Erythropoietin and erythropoietin receptor expression in normal and disturbed pregnancy
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2008Erythropoietin (Epo) is known to regulate the number of circulating erythrocytes. Epo receptor (Epo-R) expression is limited to few organs including the uterus. We investigated differences in Epo and Epo-R expression in normal and disturbed first trimester human pregnancy.Placental tissue was obtained from normal human pregnancy, abortion and ...
Bettina, Toth +5 more
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Expression of Erythropoietin and Erythropoietin Receptor in Human Dental Pulp
Journal of Endodontics, 2010In addition to the involvement in erythropoiesis, erythropoietin (EPO) and its receptor (EPO-R) have been shown to be expressed in various nonhematopoietic organs and tissues with diverse biological effects. The purpose of this study was to evaluate the expression patterns of EPO and EPO-R in healthy and inflamed human dental pulp tissues.
Qimei, Gong +4 more
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Adenosine A1 receptors and erythropoietin production
American Journal of Physiology-Cell Physiology, 1993N6-cyclopentyladenosine (CPA), a selective adenosine A1 receptor agonist, in a concentration range of 10(-9) to 10(-7) M, produced a significant decrease in erythropoietin (EPO) levels in a human hepatocellular carcinoma (Hep G2) cell culture (medium levels of EPO, 91.81 +/- 1.61 and 94.36 +/- 0.97% of control, respectively) after 24 h incubation in a
T, Ohigashi, J, Brookins, J W, Fisher
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