Results 251 to 260 of about 258,016 (314)

Production of recombinant human G protein-coupled estrogen receptor (GPER) and establishment of a ligand binding assay using graphene quantum dots (GQDs). [PDF]

PLoS One
Hossain S, Hossain MF, Sohan MSR, Omori Y, Amin MT, Tokumoto T.   +5 more
europepmc   +1 more source

Asymmetric [3,3]‐Sigmatropic Rearrangement for the Synthesis of Quaternary Center‐Containing Polycyclic Molecules: Application to the Total Synthesis of Myrmenaphthol A

ChemistryEurope, EarlyView.
A small library of tricyclic natural product‐like molecules with quaternary stereocenters is rapidly synthesized. An excellent chirality transfer from sulfur to carbon atom is observed, furnishing the desired products in 90–99% enantiomeric excesses and 51–78% isolated yields.
Weiping Zhou, Gia Hao Huynh, Arnaud Voituriez   +2 more
wiley   +1 more source

Bisphenol A Promotes the Progression of Hormone-Sensitive Breast Cancers Through Several Inflammatory Pathways. [PDF]

Cancers (Basel)
Thoene M, Zglejc-Waszak K, Jozwik M, Wojtkiewicz J.   +3 more
europepmc   +1 more source

Dietary Berberine Reduced Oxido‐Inflammatory Stress in Rats' Livers and Kidneys, Supplemented from Prepuberty to Adulthood

ChemFoodChem, EarlyView.
Berberine (BER) demonstrates significant protective effects on the hepatorenal system in rats, mediated through various cellular and molecular mechanisms spanning from the prepubertal stage through adulthood. These mechanisms encompass antioxidant, anti‐inflammatory, and anti‐apoptotic activities, in addition to modulation of essential signalling ...
Solomon Owumi, Bayode Oluwawibe, Harieme Agbarogi, Moses T. Otunla, Uche Arunsi, Jesutosin O. Babalola, Chioma Irozuru, Chima Amadi, Ahmad Altayyar   +8 more
wiley   +1 more source

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review. [PDF]

Phytother Res
Kutuk O, Kaplan A.
europepmc   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats. [PDF]

Reprod Biol Endocrinol
García-Úbeda R, Fernandez-Garcia JM, Primo U, Grassi D, Ballesta A, Arevalo MA, Collado P, Pinos H, Carrillo B.   +8 more
europepmc   +1 more source

Dual Targeting Approach Using 4‐Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue

ChemMedChem, EarlyView.
The [F7,P34]‐pNPY based peptide‐drug conjugate targets the Y1 receptor and induces internalization. Once inside the cell, 4‐hydroxytamoxifen is cleaved from the peptide and is released into the cytosol, where it activates the estrogen receptor α. This dual‐targeting mechanism aims to promote body weight loss and offers a potential therapeutic strategy ...
Anna Kohler, Eva‐Maria Jülke, Luke C. Darveniza, Jan Stichel, Annette G. Beck‐Sickinger   +4 more
wiley   +1 more source