Results 171 to 180 of about 91,326 (264)

Human Blood‐Brain Tumor Barrier on a Chip to Investigate Personalized Treatment for Glioblastoma Patients

Small, EarlyView.
A microfluidic model of the glioblastoma (GBM) margin was developed to mimic patient‐specific blood‐brain tumor barrier (BBTB) function and drug response. The platform revealed inter‐patient variability in barrier integrity and drug sensitivity, offering a tool for personalized therapy evaluation in GBM.
Minsu Ryoo, Gaeun Lee, Jinwoo Jung, Sujin Cho, Sharon Jeeho Ham, Nayeong Kang, Hyeongjin Ahn, Yu Jin Kim, JeongMin Sim, Jeongman Park, Juwon Kim, Sohyun Hwang, Jihwan Yoo, Youn‐Jung Kang, Jaejoon Lim, Jungho Ahn, Song Ih Ahn   +16 more
wiley   +1 more source

Stabilin‑1: An immunoregulatory scavenger receptor in inflammation and tissue homeostasis (Review). [PDF]

Mol Med Rep
Xiang XL, Ye XT, Wu YT, Chen C, Yu CY, Qian ST, Cai DL.   +6 more
europepmc   +1 more source

Redox‐responsive dual‐drug nanomedicine integrating cisplatin and trypsin for synergistic reversal of tumor chemoresistance

Smart Molecules, EarlyView.
This study presents a novel glutathione‐activatable prodrug nanomedicine (cRGD‐PEG‐PGlu‐NP (ssTrypsin & CDDP)) that co‐encapsulates cisplatin and a masked protease to combat cisplatin resistance. The dual‐drug system selectively targets resistant tumor cells, enhancing the efficacy of cisplatin while minimizing systemic toxicity.
Xiaolan Yin, Qi Wang, Ming Zhang, Cheng Zhang, Qixian Chen, Haidong Li, Yan Zhao, Yue Wang, Jingyun Wang, Liuwei Zhang, Hongyan Cui   +10 more
wiley   +1 more source

Sex-specific COX-2/CREB/ER signaling underlies male susceptibility to pulmonary fibrosis in rheumatoid arthritis-associated interstitial lung disease. [PDF]

Front Immunol
Kim M, Kim KS, Hong SJ, Youn J, Kim YI, Lee YA.   +5 more
europepmc   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

The extracellular matrix in peripheral nerve repair and regeneration: a narrative review of its role and therapeutic potential. [PDF]

Front Neuroanat
Metafune M, Muratori L, Fregnan F, Ronchi G, Raimondo S.   +4 more
europepmc   +1 more source

Biomarkers to predict outcomes in diabetic foot ulcers

VIEW, EarlyView.
Studies attempting to predict the healing outcome of diabetic foot ulcers (DFUs) have investigated various biological materials and recovered molecules that may aid in discriminating wounds that will heal and those that will not heal. This graphical abstract captures the commonly studied classes of biomarkers in the context of DFUs.
Julie Okiro, Kellie Fortune, Eimear Daly, Luca McCann, Merhan Soltan, Seamus Sreenan, Fabio Quondamatteo   +6 more
wiley   +1 more source

Immune regulatory mechanisms in the tumor microenvironment and their applications in cancer therapy: from basic research to clinical translation. [PDF]

Front Immunol
Feng Y, Wang Y, Li X, Wang Y, Zhang M.
europepmc   +1 more source

Nonthermal plasma approaches for combating implant‐associated infections: A compendious review

VIEW, EarlyView.
Implant‐associated infections pose serious clinical challenges. Non‐thermal plasma (NTP) modifications overcome this bottleneck in distinct ways relative to traditional sterilization methods. Gas‐phase plasmas generate highly energetic species, UV radiation and reactive oxygen/nitrogen species (RONS), which alter the implant surface properties.
A. M. Trimukhe, Satish Rojekar, Amol Gholap, K. Navaneetha Pandiyaraj, Mukesh Patekar, Claudia Riccardi, R. R. Deshmukh, Tomáš Kovářík, Kalim Deshmukh   +8 more
wiley   +1 more source