Results 181 to 190 of about 18,956 (224)

Formyl-peptide receptors revisited

Trends in Immunology, 2002
Leukocytes accumulate at sites of inflammation and microbial infection in direct response to locally produced chemotactic factors, which signal through specific G protein-coupled receptors. The first chemotactic factors to be structurally defined were the N-formyl peptides. Unlike other leukocyte chemoattractants, N-formyl peptides could originate from
Yingying, Le, Philip M, Murphy, Ji Ming, Wang   +2 more
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Pleiotropic roles of formyl peptide receptors

Cytokine & Growth Factor Reviews, 2001
FPR and FPRL1 belong to the seven-transmembrane, G protein-coupled chemoattractant receptor superfamily. Because of their capacity to interact with bacterial chemotactic formylated peptides, these receptors are thought to play a role in host defense against microbial infection.
Y, Le, J J, Oppenheim, J M, Wang
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Role of Formyl Peptide Receptors in Gastrointestinal Healing

Current Pharmaceutical Design, 2018
The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in controlling the ...
Prevete, Nella, de Paulis, Amato, Sgambato, Dolores, Melillo, Rosa Marina, D'Argenio, Giuseppe, ROMANO, LORENZO, Zagari, Rocco Maurizio, ROMANO, MARCO   +7 more
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Formyl Peptide Receptor Expression in Birds

Immunopharmacology and Immunotoxicology, 2007
N-formyl-methionyl-leucyl-phenylalanine (fMLP) is a major chemotactic factor produced by Escherichia coli and other Gram-negative bacteria. The prototypal human fMLP receptor 1 (FPR1) was cloned in 1990 from a differentiated HL-60 myeloid leukemia cell cDNA library.
PANARO, Maria Antonietta, CIANCIULLI, ANTONIA, LISI, SABRINA, SISTO, MARGHERITA, Acquafredda, A, Mitolo, V.   +5 more
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Differential Activation of Formyl Peptide Receptor Signaling by Peptide Ligands

Molecular Pharmacology, 2003
Formyl peptide receptor (FPR) and formyl peptide receptor like 1 (FPRL1) play important roles in inflammation and immunity. Stimulation of FPR and FPRL1 initiates a cascade of signaling events, leading to activation of various phagocyte responses, including chemotaxis, superoxide generation, and exocytosis.
Bae, Yoe-Sik, Song, Ji Young, Kim, Youndong, He, Rong, Ye, Richard D., Kwak, Jong-Young, Suh, Pann-Ghill, Ryu, Sung Ho   +7 more
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Conformational Aspects of Human Formyl-peptide Receptor Agonists

Arzneimittelforschung, 2011
The conformation of several Met-Ile-Phe-Leu analogues was analyzed using circular dichroism and infra-red absorption. Their effect on human neutrophils was verified by receptor binding assays and measurements of lysozyme release. The results demonstrate that in amphipatic environments the compounds examined can be highly and weakly ordered in beta-turn
DALPIAZ, Alessandro, VERTUANI, Gianni, SCATTURIN, Angelo, VITALI F., VARANI, Katia, SPISANI, Susanna   +5 more
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The N-Formyl Peptide Receptor

1999
The chemotaxis of phagocytic leukocytes from the blood to tissues identifies the acute (neutrophil) and chronic (macrophages) inflammatory condition (1). This hallmark process is central to host defense against microorganisms, to mediation of the immune response, and to repair of injured tissues. When unregulated, however, it is also the key vehicle of
John S. Mills, Heini M. Miettinen, Michael J. Vlases, Algirdas J. Jesaitis   +3 more
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Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

Trends in Immunology, 2018
Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on various host cell types but most strongly on neutrophils and macrophages. After the discovery of FPRs on leukocytes, it was assumed that these receptors predominantly govern a ...
Elisabeth, Weiß, Dorothee, Kretschmer
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Receptors for chemotactic formyl peptides as pharmacological targets

International Immunopharmacology, 2002
Leukocytes accumulate at sites of inflammation and immunological reaction in response to locally existing chemotactic mediators. N-formyl peptides, such as fMet-Leu-Phe (fMLF), are some of the first identified and most potent chemoattractants for phagocytic leukocytes.
Yingying, Le, Yiming, Yang, Youhong, Cui, Hiroshi, Yazawa, Wanghua, Gong, Cunping, Qiu, Ji Ming, Wang   +6 more
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Adaptive Evolution of Formyl Peptide Receptors in Mammals

Journal of Molecular Evolution, 2015
The formyl peptide receptors (FPRs) are a family of chemoattractant receptors with important roles in host defense and the regulation of inflammatory reactions. In humans, three FPR paralogs have been identified (FPR1, FPR2, and FPR3) and may have functionally diversified by gene duplication and adaptive evolution.
Yoshinori, Muto, Stéphane, Guindon, Toshiaki, Umemura, László, Kőhidai, Hiroshi, Ueda   +4 more
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