Results 1 to 10 of about 39,557 (145)

Molecular pathology of the FSH receptor: New insights into FSH physiology [PDF]

Molecular and Cellular Endocrinology, 2008
Manipulations of mouse genome have helped to elucidate gonadotrophin function but important differences subsist between rodent and human reproduction. Studies of patients with mutations of gonadotrophins or gonadotrophin receptors genes allow understanding their physiological effects in humans.
Meduri, G., Bachelot, A., Cocca, M.P., Vasseur, C., Rodien, P., Kuttenn, F., Touraine, P., Misrahi, M.   +7 more
openaire   +4 more sources

FSH Actions and Pregnancy: Looking Beyond Ovarian FSH Receptors [PDF]

Endocrinology, 2018
By mediating estrogen synthesis and follicular growth in response to FSH, the ovarian FSH receptor (FSHR) is essential for female fertility. Indeed, ovarian stimulation via administration of FSH to women with infertility is part of the primary therapeutic intervention used in assisted reproductive technology.
Julie A W Stilley, Deborah L Segaloff
openaire   +3 more sources

Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice [PDF]

, 2009
Development and maintenance of the male phenotype and establishment of fertility are all dependent upon the activity of the Sertoli cells and Leydig cells of the testis.
Abel, M.H., Baker, P.J., Huhtaniemi, I., Morris, I.D., O'Shaughnessy, P.J.   +4 more
core   +1 more source

Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen [PDF]

, 2008
Spermatogenesis in the adult male depends on the action of FSH and androgen. Ablation of either hormone has deleterious effects on Sertoli cell function and the progression of germ cells through spermatogenesis.
A. Monteiro, Abel, Baker, Baker, Baker, Bartles, Beardsley, Boettger-Tong, Carpenter, Casteren, Cattanach, Chang, Cheng, Czechowski, De Gendt, De Gendt, Denolet, Dierich, Dym, Eacker, F. Guillou, G. Verhoeven, H. M. Charlton, Haavisto, Haywood, Heckert, Hirst, Hofmann, Holdcraft, Johnston, Jonsson, K. De Gendt, Kageyama, Kumar, Lecureuil, Lyon, M. H. Abel, Maguire, Mayhew, McLachlan, McLachlan, Meng, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, O’Shaughnessy, P. J. Baker, P. J. O’Shaughnessy, Russell, Russell, Sadate-Ngatchou, Sadate-Ngatchou, Safina, Sharpe, Singh, Sluka, Tan, Vihko, Wong, Wreford, Yang, Zhou   +63 more
core   +2 more sources

The response to FSH treatment in oligozoospermic men depends on FSH receptor gene polymorphisms [PDF]

International Journal of Andrology, 2010
In the last years, follice-stimulating hormone (FSH) receptor (FSHR) gene polymorphisms have been studied as potential risk factors for spermatogenetic failure. In this study, we have evaluated the response of FSH treatment in terms of sperm production on the basis of Ala307Thr-Asn680Ser polymorphisms in the FSHR gene in a group of oligozoospermic ...
Selice R, Garolla A, Pengo M, Caretta N, FERLIN, ALBERTO, FORESTA, CARLO   +5 more
openaire   +3 more sources

Postendocytotic Trafficking of the Follicle-Stimulating Hormone (FSH)-FSH Receptor Complex [PDF]

Molecular Endocrinology, 2003
AbstractAlthough the fates of the internalized hormone-receptor complexes formed by the lutropin/choriogonadotropin and the TSH receptors have been examined in some detail, much less is known about the fate of the internalized FSH-FSH receptor (FSHR) complex.Using biochemical and imaging approaches we show here that the majority of the internalized FSH-
Hanumanthappa Krishnamurthy, Mei Shi, Ravi Sankar Bhaskaran, Colette Galet, Takashi Hirakawa, Hiroshi Kishi, Mario Ascoli   +6 more
openaire   +3 more sources

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]

, 2010
Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H., De Gendt, K., Monteiro, A., O'Shaughnessy, P.J., Verhoeven, G.   +4 more
core   +2 more sources

The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent. [PDF]

, 2013
The gonadotropin releasing hormone (GnRH) system in the hypothalamus is often considered the final point in integration of environmental cues as they pertain to the reproductive axis.
Bentley, George, Koh, Annie, McGuire, Nicolette   +2 more
core   +2 more sources

Functional Divergence of Glycoprotein Hormone Receptors [PDF]

, 2010
Two lamprey glycroprotein hormone receptors (lGpH-R I and II) highly similar with gnathostome GpH-Rs were cloned from sea lamprey testes and thyroid, respectively.
Freamat, Mihael, Sower, Stacia A.
core   +3 more sources

Functional Expression of FSH Receptor in Endometriotic Lesions [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2016
FSH receptor (FSHR), besides being expressed in gonads, is also expressed in some extragonadal tissues at low levels.We examined the functional expression of FSHR in different types of endometriotic lesions.Extensive studies were carried out to detect functional FSHR expression and FSH-stimulated estrogen production in ovarian endometriomas and recto ...
Iwona Sidorkiewicz, Marcin Chrusciel, Marcin Chrusciel, Slawomir Wolczynski, Slawomir Wolczynski, Donata Ponikwicka-Tyszko, Joanna Stelmaszewska, Juha S. Tapanainen, Piotr Bernaczyk, Jakub Tomaszewski, Milena Doroszko, Nafis A. Rahman, Nafis A. Rahman, Maria Sztachelska, Ilpo Huhtaniemi, Ilpo Huhtaniemi   +15 more
openaire   +4 more sources