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fsh receptor polymorphisms and ovarian function [PDF]

, 2009
La follicle-stimulating hormone (FSH) est un acteur cle en reproduction humaine. La FSH active son recepteur (FSHR) au niveau des cellules de la granulosa de l’ovaire. Les effets ovariens de la FSH endogene et exogene peuvent etre modules par des polymorphismes du gene du FSHR. A ce jour, environ 1 800 polymorphismes du FSHR ont ete rapportes.
Ochsenkühn, Robert, Von Schönfeldt, Viktoria, Simoni, Manuela   +2 more
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Studies on the mechanism of LH receptor control by FSH

Molecular and Cellular Endocrinology, 1982
Abstract The mechanism of the control of LH/hCG receptor by FSH was investigated using granulosa cells from the immature hypophysectomized estrogen primed rat as a model. The specific binding of [ 125 I]hCG to freshly collected granulosa cells was low (0.18 ± 0.01 fmoles/10 6 cells). By contrast, a marked increase in [ 125 I]hCG binding was observed
Gayle Mattson, Christina Wang, Robert F. Casper, Chris Hofeditz, Gregory F. Erickson   +4 more
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Cloning and sequencing of human FSH receptor cDNA

Biochemical and Biophysical Research Communications, 1991
We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors.
T, Minegishi, K, Nakamura, Y, Takakura, Y, Ibuki, M, Igarashi, T ], Minegish T [corrected to Minegishi   +5 more
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Regulation of FSH receptor promoter activation in the osteoclast

Biochemical and Biophysical Research Communications, 2007
We have shown recently that FSH stimulates osteoclast formation and function by a direct action on a G(i)-coupled FSH receptor (FSHR). Here, we report properties of the mouse FSH receptor promoter in the context of its activation in RAW-C3 osteoclast precursor macrophages.
Li Sun, Samir Zaidi, Rajesh Mali, Jameel Iqbal, Ling-Ling Zhu, Guozhe Yang, Mone Zaidi   +6 more
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Abnormality of testicular FSH receptors in infertile men

Acta Endocrinologica, 1984
Abstract. To ascertain whether abnormalities in testicular binding of follicle stimulating hormone (FSH) are related with spermatogenic impairment found in idiopathic male infertility, we measured FSH receptors in testicular tissues obtained by biopsy from 37 infertile men.
Keishi Matsumoto, Hiroaki Itatani, Koide T, Toshihiro Aono, Takao Sonoda, Akihiko Okuyama, Akira Miyake, N. Terada, Mikio Namiki   +8 more
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Inactivating FSH receptor mutations and gonadal dysfunction

Molecular and Cellular Endocrinology, 1998
A variety of mutations and polymorphisms of genes regulating female and male reproductive functions have been discovered during the last few years. These include several inactivating and activating mutations in LH receptor genes. The first mutation of FSH receptor (FSHR) gene was discovered in six Finnish families.
Ilpo Huhtaniemi, Juha S. Tapanainen, Tommi E. Vaskivuo, Kristiina Aittomäki, Kristiina Aittomäki   +4 more
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Functional expression of the recombinant human FSH receptor

Journal of Endocrinology, 1994
Abstract The functional capacity of the recombinant human FSH (hFSH) receptor was tested on the basis of gonadotrophin stimulation of cyclic AMP (cAMP) production by transient transfections of 293 cells and stable transfections of Chinese hamster ovary (CHO) cells.
Yoshito Ibuki, Takashi Minegishi, H Shinozaki, Kaoru Miyamoto, Mari Tano, Manabu Nakamura, Kazuhiro Nakamura, Shigeo Igarashi   +7 more
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Expression of the FSH Receptor in the Sertoli Cells

1994
The regulation of cell-specific genes could result from the interaction of unique transcription factors with specific promoter sequences. In the testes of mammals, follicle stimulating hormone receptors (FSH-Rs) are apparently located only on the Sertoli cells.
Leslie L. Heckert, Tamara L. Goetz, Michael D. Griswold, Carol C. Linder   +3 more
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Evidence that the FSH receptor itself is not a calcium channel.

Endocrinology, 1992
FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this receptor which, like all other G ...
J J Matsuda, K A Volk, Deborah L. Segaloff, K A Collison, E. F. Shibata   +4 more
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LH and FSH Receptor Mutations and Their Effects on Puberty

Hormone Research in Paediatrics, 2002
Several mutations have been detected in the genes encoding the gonadotrophin receptors, and their phenotypic effects are observed in sexual differentiation, pubertal development and fertility of the affected individuals. Both activating and inactivating mutations are known for the gonadotrophin receptors.
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