Results 71 to 80 of about 41,704 (276)

A preliminary analysis of the relationship between follicle-stimulating hormone and metabolic parameters in postmenopausal women

Gynecological Endocrinology
After menopause, women have a higher risk of developing metabolic disorders. The discovery of follicle-stimulating hormone (FSH) receptors in extra-ovarian tissues such as the adipose tissue suggests that FSH might influence metabolic processes in ...
Federica Barbagallo, Agata Cavallaro, Rossella Cannarella, Andrea Crafa, Rosita A. Condorelli, Sandro La Vignera, Laura Cucinella, Rossella E. Nappi, Aldo E. Calogero   +8 more
doaj   +1 more source

Regulatory Actions of LH and Follicle-Stimulating Hormone on Breast Cancer Cells and Mammary Tumors in Rats

Frontiers in Endocrinology, 2018
Gonadotrophins are mainly known to influence the body through the formation of gonadal steroids. However, receptors for luteinizing hormone (LH) and follicular-stimulating hormone (FSH) are present in a set of extra-gonadal tissues in humans and animals,
Angel Matias Sanchez, Angel Matias Sanchez, Marina Ines Flamini, Marina Ines Flamini, Sara Zullino, Eleonora Russo, Andrea Giannini, Paolo Mannella, Antonio Giuseppe Naccarato, Andrea Riccardo Genazzani, Tommaso Simoncini   +10 more
doaj   +1 more source

Ovarian Response to Follicle-Stimulating Hormone (FSH) Stimulation Depends on the FSH Receptor Genotype* [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2000
Abstract Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it would be of great benefit to predict the response of the patients to FSH.
Jörg Gromoll, Claudia Gassner, Eberhard Nieschlag, Maritza Perez Mayorga, Hermann M. Behre, Manuela Simoni   +5 more
openaire   +3 more sources

TSH Ligand‐Based CAR‐T Cell Effectively Eradicates TSHR‐Positive Thyroid Cancer with Favorable Safety Profile

Advanced Science, EarlyView.
TSHR is highly expressed in differentiated thyroid cancer (DTC), making it an ideal target for adoptive immune cell therapy. A novel Ligand‐based TSH‐CAR‐T cell approach effectively eradicated TSHR‐positive thyroid tumors in vitro and accomplished full remission in tumor models with favorable safety profile, highlighting that TSH‐CAR‐T cells could ...
Fei Wang, Hui Zuo, Li Liu, Shiyuan Wang, Haifang Zhao, Zhao Liu, Gang Wang, Zhao Liu, Junnian Zheng, Chuan Xu, Hongwei Du   +10 more
wiley   +1 more source

Expression of the gonadotropin receptors during follicular development

Reproductive Medicine and Biology, 2018
Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle.
Hiroshi Kishi, Yoshikazu Kitahara, Fumiharu Imai, Kohshiro Nakao, Hiroto Suwa   +4 more
doaj   +1 more source

Impact of body mass index, age and varicocele on reproductive hormone profile from elderly men

International Brazilian Journal of Urology, 2016
Objectives: To study the impact of obesity, age and varicocele on sexual hormones fof adult and elderly men. Materials and Methods: 875 men who were screened for prostate cancer were enrolled in this study.
K. G. R. Yamaçake, M. Cocuzza, F. C. M. Torricelli, B. C. Tiseo, R. Frati, G. C. Freire, A. A. Antunes, M. Srougi   +7 more
doaj   +1 more source

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs [PDF]

, 2015
Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs.
Belmonte, Norberto Miguel, Bosquiazzo, Veronica Lis, Luque, Enrique Hugo, Muñoz de Toro, Monica Milagros, Osti, Mario, Rivera, Oscar E., Rodriguez, Horacio Adolfo, Santamaría, Clarisa Guillermina, Varayoud, Jorgelina Guadalupe   +8 more
core   +2 more sources

Follitropin (FSH) and a phorbol ester stimulate the phosphorylation of the FSH receptor in intact cells.

Journal of Biological Chemistry, 1994
Using a cell line stably transfected with the rat follitropin (FSH) receptor cDNA we demonstrate that the FSH receptor becomes phosphorylated when cells are exposed to FSH. Since binding of FSH to its receptor results in an increase in cAMP and inositol phosphate accumulation, we examined the potential involvement of protein kinase A and C in mediating
Mario Ascoli, José Quintana, R W Hipkin, Jesús Sánchez-Yagüe   +3 more
openaire   +4 more sources

Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist [PDF]

ACS Medicinal Chemistry Letters, 2010
The structural resemblance of the luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) impedes selective agonistic targeting of one of those by low molecular weight (LMW) ligands. In the present study, we describe a series of dimeric ligands consisting of a LMW agonist with dual activity on the FSHR and the LHR linked to ...
Sascha Hoogendoorn, Kimberly M. Bonger, Herman S. Overkleeft, Chris J. van Koppen, Gijsbert A. van der Marel, C. Marco Timmers   +5 more
openaire   +3 more sources

Assessing Pubertal Timing, Duration, and Related Characteristics in ASXL‐Related Disorders: A Cross‐Sectional Caregiver Survey Analysis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Limited studies have been conducted on pubertal development in populations with pre‐existing medical conditions. More than 20‐fold increased risk of early puberty has been reported in neurodevelopmental disorders; however, this is a heterogeneous group.
Amanda Piring, Rebecca Hicks, Julia Sloan, Estefania Ramires‐Sanchez, Bianca E. Russell   +4 more
wiley   +1 more source