Results 101 to 110 of about 519,374 (316)

G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton

, 2005
G protein-coupled receptor kinase 2 (GRK2) phosphorylates and desensitizes activated G protein-coupled receptors (GPCRs). Here, we identify ezrin as a novel non-GPCR substrate of GRK2. GRK2 phosphorylates glutathione S-transferase (GST)-ezrin, but not an
Pitcher, JA, Cant, SH
core  

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Expression of Tas1 taste receptors in mammalian spermatozoa [PDF]

, 2012
Background: During their transit through the female genital tract, sperm have to recognize and discriminate numerous chemical compounds. However, our current knowledge of the molecular identity of appropriate chemosensory receptor proteins in sperm is ...
Ulrich Boehm (180339), de Angelis Martin Hrabé, Breit, A., Dorke Meyer, Andreas Breit (180329), Hrabě de Angelis, M., Widmayer Patricia, Wolfgang Meyerhof, Boekhoff Ingrid, Boehm, Ulrich, Martin Hrabé de Angelis, Meyer, Dorke, Ulrich Boehm, Dorke Meyer (180311), Sandra Huebner, Gudermann, T., Boehm, U., Borth, Heike, Borth Heike, Meyerhof, Wolfgang, Susan Marschall, Huebner Sandra, Voigt, Anja, Meyerhof, W., Hrabé de Angelis, Martin, Huebner, S., Sandra Huebner (180323), Thomas Gudermann (77426), Huebner, Sandra, Heike Borth, Borth, H., Susan Marschall (180334), Meyerhof Wolfgang, Ingrid Boekhoff, Ingrid Boekhoff (180345), Heike Borth (180317), Andreas Breit, Meyer Dorke, Boekhoff, I., Voigt Anja, Thomas Gudermann, Anja Voigt, Voigt, A., Gudermann Thomas, Breit Andreas, Boehm Ulrich, Marschall Susan, Marschall, Susan, Widmayer, Patricia, Widmayer, P., Wolfgang Meyerhof (7851), Patricia Widmayer, Martin Hrabé de Angelis (10007), Patricia Widmayer (180314), Breit, Andreas, Boekhoff, Ingrid, Gudermann, Thomas, Anja Voigt (173059), Marschall, S., Meyer, D.   +59 more
core   +1 more source

Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors

SLAS Discovery
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the
Joanna J. Sajkowska, Choi Har Tsang, Paweł Kozielewicz   +2 more
doaj   +1 more source

Discovery of new G protein-coupled receptors for lipid mediators

Journal of Lipid Research, 2004
Successful sequencing of the human genome has opened a new era in the life sciences and has greatly accelerated biomedical research. Among various research endeavors benefiting from established genomic information, one of the most fruitful areas is the ...
Dong-Soon Im
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Representation Learning for Class C G Protein-Coupled Receptors Classification

Molecules, 2018
G protein-coupled receptors (GPCRs) are integral cell membrane proteins of relevance for pharmacology. The complete tertiary structure including both extracellular and transmembrane domains has not been determined for any member of class C GPCRs.
Raúl Cruz-Barbosa, Erik-German Ramos-Pérez, Jesús Giraldo   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

G protein-coupled receptors: Role in metabolic disorders

Frontiers in Endocrinology, 2022
Luiz F. Barella, Shanu Jain, Sai P. Pydi
doaj   +1 more source