Results 11 to 20 of about 527,566 (280)

Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition

Frontiers in Neural Circuits, 2013
Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
doaj   +1 more source

GABA_B Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers

Life, 2023
Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment.
Ximena Delgado-Ramírez, Nara S. Alvarado-Cervantes, Natalie Jiménez-Barrios, Guadalupe Raya-Tafolla, Ricardo Felix, Vladimir A. Martínez-Rojas, Rodolfo Delgado-Lezama   +6 more
doaj   +1 more source

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. [PDF]

PLoS ONE, 2012
In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength.
Viviana Valdés, José Ignacio Valenzuela, Daniela A Salas, Matías Jaureguiberry-Bravo, Carolina Otero, Christina Thiede, Christoph F Schmidt, Andrés Couve   +7 more
doaj   +1 more source

GABA_A-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is known as the main inhibitory transmitter in the central nervous system (CNS), where it hyperpolarizes mature neurons through activation of GABAA receptors, pentameric complexes assembled by combination of subunits (α1–6,
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Ataúlfo Martínez-Torres, Daniel Reyes-Haro   +3 more
doaj   +1 more source

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Five-membered N-heterocyclic Scaffolds as Novel Amino Bioisosteres at -Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters.

Journal of Medicinal Chemistry, 2019
Given the heterogeneity within the GABA receptor and transporter families, the detailed insight into the pharmacology is still relatively sparse. To enable studies of the physiological roles governed by specific receptor and transporter subtypes, a ...
A. Giraudo, Jacob Krall, F. Bavo, B. Nielsen, K. T. Kongstad, B. Rolando, Rossella De Blasio, David E. Gloriam, Rebekka Löffler, Louise Thiesen, K. Harpsøe, K. Frydenvang, D. Boschi, P. Wellendorph, M. Lolli, A. Jensen, B. Frølund   +16 more
semanticscholar   +1 more source

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

Biomolecules, 2023
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not.
Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers   +10 more
doaj   +1 more source

New GABA amides activating GABA_A-receptors [PDF]

Beilstein Journal of Organic Chemistry, 2013
We have prepared a series of new and some literature-reported GABA-amides and determined their effect on the activation of GABAA-receptors expressed in CHO cells. Special attention was paid to the purification of the target compounds to remove even traces of GABA contaminations, which may arise from deprotection steps in the synthesis. GABA-amides were
Raster, Peter, Späth, Andreas, Bultakova, Svetlana, Gorostiza Langa, Pablo Ignacio, König, Burkhard, Bregestovski, Piotr   +5 more
openaire   +5 more sources