Results 11 to 20 of about 177,108 (289)

GABA_B Receptors Tonically Inhibit Motoneurons and Neurotransmitter Release from Descending and Primary Afferent Fibers

Life, 2023
Motoneurons receive thousands of excitatory and inhibitory synapses from descending tracts and primary afferent fibers. The excitability of these neurons must be precisely regulated to respond adequately to the requirements of the environment.
Ximena Delgado-Ramírez, Nara S. Alvarado-Cervantes, Natalie Jiménez-Barrios, Guadalupe Raya-Tafolla, Ricardo Felix, Vladimir A. Martínez-Rojas, Rodolfo Delgado-Lezama   +6 more
doaj   +1 more source

Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition

Frontiers in Neural Circuits, 2013
Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
doaj   +1 more source

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Calandra, Ricardo S., Doepner, Richard F. G., Frungieri, Monica B., Gamel-Didelon, Katia, Geigerseder, Christof, Kohn, Frank M., Mayerhofer, Artur, Thalhammer, Andrea   +7 more
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Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor

BMC Research Notes, 2012
Background GABA receptors are well known as the inhibitory receptors in the central nervous system and are also found in peripheral tissues. We have previously shown that GABA receptors are involved in lung development and fluid homeostasis. However, the
Zhao Chunling, Huang Chaoqun, Weng Tingting, Xiao Xiao, Ma Hong, Liu Lin   +5 more
doaj   +1 more source

GABA_A-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia

Neuroglia, 2023
Gamma-aminobutyric acid (GABA) is known as the main inhibitory transmitter in the central nervous system (CNS), where it hyperpolarizes mature neurons through activation of GABAA receptors, pentameric complexes assembled by combination of subunits (α1–6,
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Ataúlfo Martínez-Torres, Daniel Reyes-Haro   +3 more
doaj   +1 more source

Neurosteroids and GABA-A Receptor Function [PDF]

Frontiers in Endocrinology, 2011
Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor. 3α-hydroxy A-ring reduced metabolites of progesterone, deoxycorticosterone, and testosterone are positive modulators of GABA(A)-receptor in a non-genomic manner ...
openaire   +3 more sources

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia, Kelley, Stephen P., Peppiatt-Wildman, Claire M., Wildman, Scott S.P.   +3 more
core   +1 more source

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source

Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]

, 2012
Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S, Dellal, Shlomo S, Feng, Feng, Otis, Thomas S, Pawlowski, Michal, Pepperberg, David R, Qian, Haohua, Xie, An, Yue, Lan   +8 more
core   +2 more sources

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source