ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca+3 more
wiley +1 more source
Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies? [PDF]
Laghetti P+4 more
europepmc +1 more source
The continuing significance of chiral agrochemicals
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Phenotypic Spectrum in Individuals With Pathogenic <i>GABRG2</i> Loss- and Gain-of-Function Variants. [PDF]
Rossi A+56 more
europepmc +1 more source
Decision‐making in entrepreneurial teams with competing economic and noneconomic goals
Abstract Research Summary How should decision‐making be organized in entrepreneurial teams pursuing competing economic and noneconomic goals? Using a computational model, we examine how four archetypical decision‐making structures—unanimous approval, individual autonomy, majority voting, and lead entrepreneur—shape the performance of entrepreneurial ...
Jeroen Neckebrouck, Thomas Zellweger
wiley +1 more source
Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models. [PDF]
Fudge JL, Kelly EA, Mahoui I.
europepmc +1 more source
Unpacking the inertia in resource allocation adjustments of multi‐business firms
Abstract Research Summary Resource allocation inertia—firms' insufficient responsiveness in adjusting resource allocation across business units—hinders adaptation and competitive advantage. Yet, it is unclear why some firms are more prone to this inertia.
Niklas M. Lindlbauer+2 more
wiley +1 more source
Pleiotropic neurotransmitters: neurotransmitter-receptor crosstalk regulates excitation-inhibition balance in social brain functions and pathologies. [PDF]
Chai A.
europepmc +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong+4 more
wiley +1 more source
Proteostasis regulation of GABA<sub>A</sub> receptors in neuronal function and disease. [PDF]
Chen X, Wang YJ, Mu TW.
europepmc +1 more source