Results 181 to 190 of about 176,942 (307)

Mu-opioid and nociceptin receptors show divergent, cell-type-specific actions in the mesocorticolimbic reward system in opioid use disorder. [PDF]

Front Cell Neurosci
Allichon MC, Espinosa J, Cole RH, Ko MC, Vanhoutte P, Joffe ME.   +5 more
europepmc   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Fluorine-18 Radiolabeled Single-Chain Antibody Variable Fragment 1F4 Targets α1-Subunit Gamma-Aminobutyric Acid Type A Receptors in Mice. [PDF]

J Med Chem
García de Lucas Á, Samani NA, Moisio O, Kovacs L, Savela R, Soini SL, Oksanen S, Helin JS, Rajander J, Airaksinen AJ, Lamminmäki U, López-Picón F.   +11 more
europepmc   +1 more source

Impact of cenobamate on cortical responses to transcranial magnetic stimulation in people with drug‐resistant focal epilepsy

Epilepsia Open, EarlyView.
Abstract Objective Cenobamate (CNB) is an effective antiseizure medication, though its mechanisms of efficacy remain incompletely understood. We assessed changes in cortical responses to transcranial magnetic stimulation (TMS) following CNB treatment.
Silvano R. Gefferie, Diego Jiménez‐Jiménez, Gerhard H. Visser, Robert M. Helling, Arn M. J. M. van den Maagdenberg, Josemir W. Sander, Simona Balestrini, Roland D. Thijs   +7 more
wiley   +1 more source

Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABA_A Receptors in a Rat Double-Hit Stress Model. [PDF]

Pharmacol Res Perspect
Đorović Đ, Aranđelović J, Ivanović J, Jezdić K, Batinić B, Sharmin D, Mondal P, Cook JM, Savić MM.   +8 more
europepmc   +1 more source

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

Epilepsia Open, EarlyView.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci, Robyn Whitney, Adrian Budhram, Maryam Nabavi Nouri   +3 more
wiley   +1 more source

Molecular assemblies and pharmacology of cerebellar GABA_A receptors. [PDF]

Proc Natl Acad Sci U S A
Sun C, Jahncke JN, Wright KM, Gouaux E.
europepmc   +1 more source

An iEEG investigation on sex‐specific differences in seizure duration

Epilepsia Open, EarlyView.
Abstract Objective Male people with epilepsy (mPWE) are at higher risk for bilateral tonic–clonic seizures (BTCs) and sudden unexpected death in epilepsy (SUDEP) compared to female people with epilepsy (fPWE). Despite major clinical and personal implications, little is known about sex‐specific differences in seizure propagation and termination ...
Paula Albert I Gracenea, Alexandra Muss, Magdalena Seethaler, Jan Rémi, Elisabeth Kaufmann   +4 more
wiley   +1 more source

Causal interhemispheric neuromodulation sharpens synaptic and neurobehavioral inhibition in stroke. [PDF]

Brain Commun
Castelhano J, Duecker F, Xavier AC, Canário N, Duarte IC, Afonso S, Marques AG, Lourenço C, Carvalho F, Lains J, Neves A, Freitas JS, Santo GC, Abrunhosa AJ, Sack AT, Castelo-Branco M.   +15 more
europepmc   +1 more source

Artificial intelligence in the assessment of epilepsy‐related genetic mutations: Learned from GABAA receptors and GABA transporter 1

Epilepsia Open, EarlyView.
Abstract This review examines how recent genetic and technological advances have transformed our understanding and treatment of genetic epilepsies (GEs), with a focus on disorders involving GABAA receptors (GABRs) and the GABA transporter 1 (GAT‐1) encoded by SLC6A1.
Juexin Wang, Jing‐Qiong Kang
wiley   +1 more source