Activity- and sleep-dependent regulation of tonic inhibition by Shisa7 [PDF]
Cell Reports, 2021 Summary: Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABAARs) critically regulates neuronal excitability and brain function. However, the mechanisms regulating tonic inhibition remain poorly understood.
Kunwei Wu +4 more
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GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex [PDF]
Frontiers in Cellular Neuroscience, 2023 Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj +2 more
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Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons [PDF]
Frontiers in Cellular Neuroscience, 2023 GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak +2 more
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Suppressing astrocytic GABA transaminase enhances tonic inhibition and weakens hippocampal spatial memory [PDF]
Experimental and Molecular MedicinePharmacological suppression of γ-aminobutyric acid (GABA) transaminase (GABA-T), the sole GABA-degrading enzyme and a potential therapeutic target for treating brain disorders such as epilepsy, increases not only phasic inhibition but also tonic ...
Mingu Gordon Park +5 more
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Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model [PDF]
Frontiers in Pharmacology, 2022 Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse ...
Yousif Aldabbagh +4 more
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Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination [PDF]
Experimental and Molecular MedicineTonic inhibition in cerebellar granule cells is crucial for maintaining information coding fidelity during motor coordination. It arises through both activity-dependent and activity-independent mechanisms, and the interplay between these mechanisms ...
Jea Kwon +7 more
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Chronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala [PDF]
Frontiers in Neuroscience, 2020 Chronic or prolonged exposure to stress ranks among the most important socioenvironmental factors contributing to the development of neuropsychiatric diseases, a process generally associated with loss of inhibitory tone in amygdala.
Han-Qing Pan +18 more
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Frontiers in Neural Circuits, 2014 The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations during subunit assembly give rise to a variety of receptors with different functional properties. This heterogeneity results in variations in GABAergic conductances across
Vallent eLee, Jamie eMaguire
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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron [PDF]
Experimental Biology and MedicineProlonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural
Zhiqiang Yu +4 more
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Neurobiology of Disease, 2010 Neurosteroid sensitivity of GABAA receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy.
Karthik Rajasekaran +4 more
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