Activity- and sleep-dependent regulation of tonic inhibition by Shisa7 [PDF]
Cell Reports, 2021 Summary: Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABAARs) critically regulates neuronal excitability and brain function. However, the mechanisms regulating tonic inhibition remain poorly understood.
Kunwei Wu +4 more
doaj +7 more sources
GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex [PDF]
Frontiers in Cellular Neuroscience, 2023 Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj +2 more
doaj +4 more sources
Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition [PDF]
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
doaj +8 more sources
Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers [PDF]
J Neurosci, 2017 Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABA A receptors substantially reduced chloride concentration in granule cells due to block of tonic ...
Augustine, G. J. +4 more
core +11 more sources
Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons [PDF]
Frontiers in Cellular Neuroscience, 2023 GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak +2 more
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The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum [PDF]
Molecular Brain, 2011 A tonic form of synaptic inhibition occurs in discrete regions of the central nervous system and has an important role in controlling neuronal excitability.
Yoon Bo-Eun +6 more
doaj +3 more sources
Monoamine modulation of tonic GABAA inhibition [PDF]
Reviews in the Neurosciences, 2014 In recent years, it has become evident that many neurotransmitters and endogenous ligands differentially modulate synaptic γ-aminobutyric acid type A receptors (sGABAARs) and extrasynaptic GABAAR (eGABAARs).
Crunelli, Vincenzo +1 more
core +5 more sources
Suppressing astrocytic GABA transaminase enhances tonic inhibition and weakens hippocampal spatial memory [PDF]
Experimental and Molecular MedicinePharmacological suppression of γ-aminobutyric acid (GABA) transaminase (GABA-T), the sole GABA-degrading enzyme and a potential therapeutic target for treating brain disorders such as epilepsy, increases not only phasic inhibition but also tonic ...
Mingu Gordon Park +5 more
doaj +2 more sources
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]
Neurobiology of Stress, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli +3 more
doaj +3 more sources
Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model [PDF]
Frontiers in Pharmacology, 2022 Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse ...
Yousif Aldabbagh +4 more
doaj +2 more sources