Activity- and sleep-dependent regulation of tonic inhibition by Shisa7 [PDF]
Cell Reports, 2021 Summary: Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABAARs) critically regulates neuronal excitability and brain function. However, the mechanisms regulating tonic inhibition remain poorly understood.
Kunwei Wu +4 more
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Chronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala [PDF]
Frontiers in Neuroscience, 2020 Chronic or prolonged exposure to stress ranks among the most important socioenvironmental factors contributing to the development of neuropsychiatric diseases, a process generally associated with loss of inhibitory tone in amygdala.
Han-Qing Pan +18 more
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Role of tonic inhibition in associative reward conditioning in Lymnaea [PDF]
Frontiers in Behavioral Neuroscience, 2010 Changes in the strength of excitatory synaptic connections are known to underlie associative memory formation in the molluscan nervous system but less is known about the role of synaptic inhibition.
Vincenzo Marra +5 more
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GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex [PDF]
Frontiers in Cellular Neuroscience, 2023 Extrasynaptic GABAA receptors (GABAARs) mediating tonic inhibition are thought to play an important role in the regulation of neuronal excitability. However, little is known about a cell type-specific tonic inhibition in molecularly distinctive types of ...
Karolina Bogaj +2 more
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Bidirectional plasticity of GABAergic tonic inhibition in hippocampal somatostatin- and parvalbumin-containing interneurons [PDF]
Frontiers in Cellular Neuroscience, 2023 GABAA receptors present in extrasynaptic areas mediate tonic inhibition in hippocampal neurons regulating the performance of neural networks. In this study, we investigated the effect of NMDA-induced plasticity on tonic inhibition in somatostatin- and ...
Marcin Wyroślak +2 more
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Suppressing astrocytic GABA transaminase enhances tonic inhibition and weakens hippocampal spatial memory [PDF]
Experimental and Molecular MedicinePharmacological suppression of γ-aminobutyric acid (GABA) transaminase (GABA-T), the sole GABA-degrading enzyme and a potential therapeutic target for treating brain disorders such as epilepsy, increases not only phasic inhibition but also tonic ...
Mingu Gordon Park +5 more
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Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model [PDF]
Frontiers in Pharmacology, 2022 Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse ...
Yousif Aldabbagh +4 more
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Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination [PDF]
Experimental and Molecular MedicineTonic inhibition in cerebellar granule cells is crucial for maintaining information coding fidelity during motor coordination. It arises through both activity-dependent and activity-independent mechanisms, and the interplay between these mechanisms ...
Jea Kwon +7 more
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Recurrent neonatal seizures increase tonic inhibition and respond to enhancers of δ-containing GABAA receptors [PDF]
JCI InsightAbout one-third of neonatal seizures do not respond to the first-line anticonvulsant phenobarbital, which activates phasic inhibition and whose effectiveness decreases over time.
Gage T. Liddiard +3 more
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Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition [PDF]
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
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