Results 1 to 10 of about 1,069,702 (278)
Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition [PDF]
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
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The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum [PDF]
Molecular Brain, 2011 A tonic form of synaptic inhibition occurs in discrete regions of the central nervous system and has an important role in controlling neuronal excitability.
Yoon Bo-Eun +6 more
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Cell Reports, 2018 Summary: The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson’s disease (PD), the rate and pattern of activity of GP neurons are profoundly altered and ...
Marine Chazalon +10 more
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GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Robert John Hatch +2 more
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Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Frontiers in Synaptic Neuroscience, 2022 Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses.
Riley T. Paulsen, Brian D. Burrell
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Metabotropic Regulation of Extrasynaptic GABAA Receptors
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Pathophysiological power of improper tonic GABAA conductances in mature and immature models
Frontiers in Neural Circuits, 2013 High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
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Cells, 2020 A decrease in synaptic plasticity and/or a change in excitation/inhibition balance have been suggested as mechanisms underlying major depression disorder.
Ipsit Srivastava +4 more
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Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
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Frontiers in Neural Circuits, 2014 The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations during subunit assembly give rise to a variety of receptors with different functional properties. This heterogeneity results in variations in GABAergic conductances across
Vallent eLee, Jamie eMaguire
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