Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]
, 2015 GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A. +9 more
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Cells, 2020 A decrease in synaptic plasticity and/or a change in excitation/inhibition balance have been suggested as mechanisms underlying major depression disorder.
Ipsit Srivastava +4 more
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Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]
, 2014 Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole +16 more
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The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex [PDF]
The Korean Journal of Physiology and Pharmacology, 2010 Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABA(A) receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic ...
Hyun-Jong, Jang +5 more
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Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons [PDF]
, 2014 Synaptic plasticity rules change during development: while hippocampal synapses can be potentiated by a single action potential pairing protocol in young neurons, mature neurons require burst firing to induce synaptic potentiation. An essential component
Nevian, Thomas +16 more
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Neurosteroids Mediate Habituation and Tonic Inhibition in the Auditory Midbrain [PDF]
Journal of Neurophysiology, 2001 Habituation of the behavioral response to a repetitive stimulus is a well-established observation in perceptual studies and is considered a basic form of nonassociative learning. There is also a long history of physiological studies suggesting that central nervous system habituation is mediated by inhibition.
Disney, A, Calford, Mike B
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Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model
Frontiers in Molecular Neuroscience, 2019 Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil +6 more
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The mechanism of tonic inhibition of crayfish escape behavior: distal inhibition and its functional significance [PDF]
, 1993 The excitability of crayfish escape behavior is seldom fully predictable. A major determinant of this fickleness is a form of descending inhibition that is reliably evoked during restraint or feeding and is called “tonic inhibition.” Tonic inhibition was
ET Vu, SC Lee, FB Krasne
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PLoS ONE, 2013 Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in ...
Marvin R Diaz +4 more
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Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Neurobiology of Stress, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli +3 more
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