Results 41 to 50 of about 1,069,702 (278)

The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex [PDF]

The Korean Journal of Physiology and Pharmacology, 2010
Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABA(A) receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic ...
Hyun-Jong, Jang, Kwang-Hyun, Cho, Sung-Won, Park, Myung-Jun, Kim, Shin Hee, Yoon, Duck-Joo, Rhie   +5 more
openaire   +2 more sources

Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity. [PDF]

, 2015
GABA transporters control extracellular GABA, which regulates the key aspects of neuronal and network behaviour. A prevailing view is that modest neuronal depolarization results in GABA transporter type-1 (GAT-1) reversal causing non-vesicular GABA ...
Rusakov, Dmitri A., Walker, MC, Savtchenko, L, Pavlov, I, Megalogeni, M, Walker, Matthew C., Rusakov, DA, Savtchenko, Leonid, Pavlov, Ivan, Megalogeni, Maria   +9 more
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Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
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Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons [PDF]

, 2014
Synaptic plasticity rules change during development: while hippocampal synapses can be potentiated by a single action potential pairing protocol in young neurons, mature neurons require burst firing to induce synaptic potentiation. An essential component
Nevian, Thomas, Wortel, J., Nevian, T., Mansvelder, H.D.; id_orcid, van Ooijen, A., Mansvelder, H.D., Mansvelder, H. D., Dekker, M. P., Pérez Garci, Enrique, Meredith, R. M., Groen, M. R., van Ooyen, A., Groen, M.R., Dekker, M.P., Meredith, R.M., Paulsen, O., Pérez-Garci, E.   +16 more
core   +1 more source

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Frontiers in Molecular Neuroscience, 2019
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Stephen J. Moss, Paul A. Davies   +6 more
doaj   +1 more source

Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors

Pharmaceuticals
Cell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized
Abraham Rosas-Arellano
doaj   +1 more source

Na+/K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells.

PLoS ONE, 2013
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in ...
Marvin R Diaz, Aya Wadleigh, Shyam Kumar, Erik De Schutter, C Fernando Valenzuela   +4 more
doaj   +1 more source

Neurosteroids Mediate Habituation and Tonic Inhibition in the Auditory Midbrain [PDF]

Journal of Neurophysiology, 2001
Habituation of the behavioral response to a repetitive stimulus is a well-established observation in perceptual studies and is considered a basic form of nonassociative learning. There is also a long history of physiological studies suggesting that central nervous system habituation is mediated by inhibition.
Disney, A, Calford, Mike B
openaire   +2 more sources

Relationship between tonic inhibitory currents and phasic inhibitory activity in the spinal cord lamina II region of adult mice

Molecular Pain, 2006
Phasic and tonic inhibitions are two types of inhibitory activities involved in inhibitory processing in the CNS. In the spinal cord dorsal horn, phasic inhibition is mediated by both GABAergic and glycinergic inhibitory postsynaptic currents.
Ataka Toyofumi, Gu Jianguo G
doaj   +1 more source

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Neurobiology of Stress, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. Lambert   +3 more
doaj   +1 more source