Results 51 to 60 of about 103,968 (278)
GABA A Receptor-Mediated Tonic Inhibition in Thalamic Neurons [PDF]
The Journal of Neuroscience, 2005 Tonic GABA A receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the δ subunit is highly expressed in the thalamus, we tested whether thalamocortical (TC) neurons of the dorsal lateral geniculate nucleus (dLGN) and ventrobasal complex ...
Cope, David W. +2 more
openaire +3 more sources
PLoS ONE, 2014 Motoneurons are furnished with a vast repertoire of ionotropic and metabotropic receptors as well as ion channels responsible for maintaining the resting membrane potential and involved in the regulation of the mechanisms underlying its membrane ...
Carmen Andres +5 more
doaj +1 more source
Crayfish tonic inhibition: prolonged modulation of behavioral excitability by classical GABAergic inhibition [PDF]
The Journal of Neuroscience, 1993 Previous studies have indirectly implicated the two neurotransmitters 5- HT and GABA in mediating tonic inhibition of the crayfish lateral giant (LG) escape reaction. In this study, pharmacological agents were selectively delivered to restricted portions of the abdominal CNS (where LG escape circuitry resides) to assess directly the role of these two ...
E T, Vu, F B, Krasne
openaire +2 more sources
Altered brainstem responses to modafinil in schizophrenia: implications for adjunctive treatment of cognition. [PDF]
, 2018 Candidate pro-cognitive drugs for schizophrenia targeting several neurochemical systems have consistently failed to demonstrate robust efficacy. It remains untested whether concurrent antipsychotic medications exert pharmacodynamic interactions that ...
Carter, Cameron S +3 more
core +3 more sources
Journal of Integrative NeuroscienceObjective: Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest.
Kile P. Mangan +4 more
doaj +1 more source
Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy
Frontiers in Neurology, 2020 An imbalance of excitation and inhibition has been associated with the pathophysiology of epilepsy. Loss of GABAergic interneurons and/or synaptic inhibition has been shown in various epilepsy models and in human epilepsy.
Julia Müller +5 more
doaj +1 more source
Neural Regeneration Research, 2018 γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB, the first one is responsible to render tonic inhibition ...
Abraham Rosas-Arellano +4 more
doaj +1 more source
A-type GABA receptor as a central target of TRPM8 agonist menthol. [PDF]
PLoS ONE, 2008 Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons.
Xiao-Bing Zhang +7 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2014 Tonic GABAergic inhibition regulates neuronal excitability and has been implicated to be involved in both neurological and psychiatric diseases. We have previously shown that the endogenous peptide antisecretory factor (AF) decreases phasic GABAergic ...
Joakim eStrandberg +4 more
doaj +1 more source