Results 51 to 60 of about 1,069,702 (278)

Extrasynaptic α6 subunit-containing GABAA receptors modulate excitability in turtle spinal motoneurons.

PLoS ONE, 2014
Motoneurons are furnished with a vast repertoire of ionotropic and metabotropic receptors as well as ion channels responsible for maintaining the resting membrane potential and involved in the regulation of the mechanisms underlying its membrane ...
Carmen Andres, Justo Aguilar, Ricardo González-Ramírez, David Elias-Viñas, Ricardo Felix, Rodolfo Delgado-Lezama   +5 more
doaj   +1 more source

Cortical Tonic Inhibition Gates the Expression of Spike-and-Wave Discharges Associated with Absence Epilepsy

Journal of Integrative Neuroscience
Objective: Absence seizures result from aberrant thalamocortical processing that confers synchronous, bilateral spike-and-wave discharges (SWDs) and behavioral arrest.
Kile P. Mangan, Aaron B. Nelson, Steven Petrou, Chiara Cirelli, Mathew V. Jones   +4 more
doaj   +1 more source

Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy

Frontiers in Neurology, 2020
An imbalance of excitation and inhibition has been associated with the pathophysiology of epilepsy. Loss of GABAergic interneurons and/or synaptic inhibition has been shown in various epilepsy models and in human epilepsy.
Julia Müller, Aline Timmermann, Lukas Henning, Hendrik Müller, Christian Steinhäuser, Peter Bedner   +5 more
doaj   +1 more source

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Walker, M.C., Sperk, G., Scimemi, A., Semyanov, A., Kullmann, D.M.   +4 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The adjustment of γ-aminobutyric acidA tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum

Neural Regeneration Research, 2018
γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB, the first one is responsible to render tonic inhibition ...
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Carola A Mantellero, Carlos Tejeda-Guzmán, Maite A Castro   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The endogenous peptide antisecretory factor promotes tonic GABAergic signalling in CA1 stratum radiatum interneurons

Frontiers in Cellular Neuroscience, 2014
Tonic GABAergic inhibition regulates neuronal excitability and has been implicated to be involved in both neurological and psychiatric diseases. We have previously shown that the endogenous peptide antisecretory factor (AF) decreases phasic GABAergic ...
Joakim eStrandberg, Catarina eLindquist, Stefan eLange, Fredrik eAsztely, Eric eHanse   +4 more
doaj   +1 more source

A-type GABA receptor as a central target of TRPM8 agonist menthol. [PDF]

PLoS ONE, 2008
Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons.
Xiao-Bing Zhang, Peng Jiang, Neng Gong, Xiao-Ling Hu, Da Fei, Zhi-Qi Xiong, Lin Xu, Tian-Le Xu   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source