Results 31 to 40 of about 1,069,702 (278)

Monoamine modulation of tonic GABAA inhibition [PDF]

Reviews in the Neurosciences, 2014
In recent years, it has become evident that many neurotransmitters and endogenous ligands differentially modulate synaptic γ-aminobutyric acid type A receptors (sGABAARs) and extrasynaptic GABAAR (eGABAARs). In this mini-review, we will summarize the available evidence on the ability of the monoamines serotonin (5-HT), noradrenaline (NA), and, in ...
Crunelli, Vincenzo, Di Giovanni, Giuseppe   +1 more
openaire   +3 more sources

Tonic inhibition of chemotaxis in human plasma [PDF]

Proceedings of the National Academy of Sciences, 2008
We found exaggerated chemotaxis in plasma treated with EDTA and thought that the EDTA might itself be inhibiting a tonic inhibitor(s) of chemotaxis. Our plasma fractionations suggested that evidence should be sought for a lipid moiety carrying this activity, and on spectrometry (LC-MS-MS together with GC-MS analyses), the biologically active but not ...
Malawista, Stephen E., Chevance, Anne Boisfleury, Damme, Jo van, Serhan, Charles N.   +3 more
openaire   +4 more sources

Tonic inhibition of chronic pain by neuropeptide Y [PDF]

Proceedings of the National Academy of Sciences, 2011
Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signals. We found that doxycycline-induced conditional in vivo ( Npy tet/tet ) knockdown
Brian, Solway, Soma C, Bose, Gregory, Corder, Renee R, Donahue, Bradley K, Taylor   +4 more
openaire   +2 more sources

Homeostatic Competition between Phasic and Tonic Inhibition [PDF]

Journal of Biological Chemistry, 2013
The GABAA receptors are the major inhibitory receptors in the brain and are localized at both synaptic and extrasynaptic membranes. Synaptic GABAA receptors mediate phasic inhibition, whereas extrasynaptic GABAA receptors mediate tonic inhibition. Both phasic and tonic inhibitions regulate neuronal activity, but whether they regulate each other is not ...
Xia, Wu, Lanting, Huang, Zheng, Wu, Ce, Zhang, Dongyun, Jiang, Yuting, Bai, Yun, Wang, Gong, Chen   +7 more
openaire   +2 more sources

A new meaning for “Gin & Tonic”: tonic inhibition as the target for ethanol action in the brain [PDF]

Alcohol, 2007
Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system, it acts on two distinct types of receptor: an ion channel, that is, an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors [GABAARs]) and a G-protein coupled "metabotropic" receptor that is linked to various ...
Istvan, Mody, Joseph, Glykys, Weizheng, Wei   +2 more
openaire   +2 more sources

GABA-Independent GABAA Receptor Openings Maintain Tonic Currents [PDF]

, 2013
Activation of GABAA receptors (GABAARs) produces two forms of inhibition: ‘phasic’ inhibition generated by the rapid, transient activation of synaptic GABAARs by presynaptic GABA release, and tonic inhibition generated by the persistent activation of ...
Herd, Murray B, Belelli, D., Wlodarczyk, A. I., Sylantyev, S., Linthorst, Astrid C.E., Walker, Matthew C., Walker, M. C., Rusakov, Dmitri A, Lambert, Jeremy J, Wlodarczyk, Agnieszka I., Kersanté, Flavie, Walker, Matthew C, Semyanov, A., Semyanov, Alexey, Rusakov, Dmitri A., Rusakov, D. A., Herd, Murray B., Linthorst, A. C. E., Lambert, Jeremy J., Pavlov, I., Linthorst, Astrid C E, Lambert, J. J., Herd, M. B., Kersante, F., Wlodarczyk, Agnieszka I, Pavlov, Ivan, Sylantyev, Sergiy, Belelli, Delia   +27 more
core   +1 more source

The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABA_A receptor-mediated inhibition [PDF]

, 2014
Modulation of thalamocortical (TC) relay neuron function has been implicated in the sedative and hypnotic effects of general anaesthetics. Inhibition of TC neurons is mediated predominantly by a combination of phasic and tonic inhibition, together with a
Herd, Murray B., Lambert, Jeremy J., Delia Belelli, Jeremy J. Lambert, Belelli, Delia, Murray B. Herd   +5 more
core   +1 more source

Modulating anxiety with extrasynaptic inhibition [PDF]

, 2014
Traumatic experiences and stress can lead to complex behavioral adaptations, including increased levels of anxiety and fear generalization. The neuronal mechanisms underlying such maladaptive behavioral changes are, however, poorly understood.
Botta, Paolo
core   +1 more source

Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes [PDF]

Journal of Investigative Dermatology, 2012
The transient receptor potential vanilloid 3 channel (TRPV3) is abundantly expressed in epidermal keratinocytes and has important roles in sensory biology and skin health. Mg(2+) deficiency causes skin disorders under certain pathological conditions such as type 2 diabetes mellitus.
Luo, Jialie, Stewart, Randi, Berdeaux, Rebecca, Hu, Hongzhen   +3 more
openaire   +2 more sources

Cyfip1 haploinsufficiency does not alter GABAA receptor δ-subunit expression and tonic inhibition in dentate gyrus PV+ interneurons and granule cells [PDF]

, 2019
Copy number variation at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) interacting ...
Connelly, William M, Errington, Adam C., Connelly, William M., Hall, Jeremy, Trent, Simon   +4 more
core   +1 more source