Results 31 to 40 of about 54,149 (242)
The Development of Phasic and Tonic Inhibition in the Rat Visual Cortex [PDF]
The Korean Journal of Physiology and Pharmacology, 2010 Gamma-aminobutyric acid (GABA)-ergic inhibition is important in the function of the visual cortex. In a previous study, we reported a developmental increase in GABA(A) receptor-mediated inhibition in the rat visual cortex from 3 to 5 weeks of age. Because this developmental increase is crucial to the regulation of the induction of long-term synaptic ...
Hyun-Jong, Jang +5 more
openaire +2 more sources
Cells, 2020 A decrease in synaptic plasticity and/or a change in excitation/inhibition balance have been suggested as mechanisms underlying major depression disorder.
Ipsit Srivastava +4 more
doaj +1 more source
Extrasynaptic δ-subunit containing GABAA receptors [PDF]
Journal of Integrative Neuroscience, 2021 γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
doaj +1 more source
Neurosteroids Mediate Habituation and Tonic Inhibition in the Auditory Midbrain [PDF]
Journal of Neurophysiology, 2001 Habituation of the behavioral response to a repetitive stimulus is a well-established observation in perceptual studies and is considered a basic form of nonassociative learning. There is also a long history of physiological studies suggesting that central nervous system habituation is mediated by inhibition.
Disney, A, Calford, Mike B
openaire +2 more sources
Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model
Frontiers in Molecular Neuroscience, 2019 Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS.
Amit Modgil +6 more
doaj +1 more source
Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes [PDF]
Cell Reports, 2021 SUMMARY Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABA A Rs) play important roles in the regulation of various brain functions. However, the regulatory mechanisms for tonic inhibition remain largely unknown.
Kunwei Wu +3 more
openaire +3 more sources
Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors
PharmaceuticalsCell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized
Abraham Rosas-Arellano
doaj +1 more source
PLoS ONE, 2013 Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in ...
Marvin R Diaz +4 more
doaj +1 more source
Molecular Pain, 2006 Phasic and tonic inhibitions are two types of inhibitory activities involved in inhibitory processing in the CNS. In the spinal cord dorsal horn, phasic inhibition is mediated by both GABAergic and glycinergic inhibitory postsynaptic currents.
Ataka Toyofumi, Gu Jianguo G
doaj +1 more source
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Neurobiology of Stress, 2020 In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli +3 more
doaj +1 more source