Results 21 to 30 of about 54,149 (242)
Monoamine modulation of tonic GABAA inhibition [PDF]
Reviews in the Neurosciences, 2014 In recent years, it has become evident that many neurotransmitters and endogenous ligands differentially modulate synaptic γ-aminobutyric acid type A receptors (sGABAARs) and extrasynaptic GABAAR (eGABAARs). In this mini-review, we will summarize the available evidence on the ability of the monoamines serotonin (5-HT), noradrenaline (NA), and, in ...
Crunelli, Vincenzo +1 more
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Tonic inhibition of chemotaxis in human plasma [PDF]
Proceedings of the National Academy of Sciences, 2008 We found exaggerated chemotaxis in plasma treated with EDTA and thought that the EDTA might itself be inhibiting a tonic inhibitor(s) of chemotaxis. Our plasma fractionations suggested that evidence should be sought for a lipid moiety carrying this activity, and on spectrometry (LC-MS-MS together with GC-MS analyses), the biologically active but not ...
Malawista, Stephen E. +3 more
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Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Frontiers in Synaptic Neuroscience, 2022 Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses.
Riley T. Paulsen, Brian D. Burrell
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Tonic inhibition of chronic pain by neuropeptide Y [PDF]
Proceedings of the National Academy of Sciences, 2011 Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signals. We found that doxycycline-induced conditional in vivo ( Npy tet/tet ) knockdown
Brian, Solway +4 more
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A new meaning for “Gin & Tonic”: tonic inhibition as the target for ethanol action in the brain [PDF]
Alcohol, 2007 Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system, it acts on two distinct types of receptor: an ion channel, that is, an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors [GABAARs]) and a G-protein coupled "metabotropic" receptor that is linked to various ...
Istvan, Mody +2 more
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Enhanced tonic GABAA inhibition in typical absence epilepsy [PDF]
Nature Medicine, 2009 The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired gamma-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis. In contrast, we show here that extrasynaptic GABA(A) receptor-dependent 'tonic' inhibition is increased in ...
Cope, DW +8 more
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Metabotropic Regulation of Extrasynaptic GABAA Receptors
Frontiers in Neural Circuits, 2013 A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under ...
William Martin Connelly +3 more
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Pathophysiological power of improper tonic GABAA conductances in mature and immature models
Frontiers in Neural Circuits, 2013 High-affinity extrasynaptic gamma-aminobutyric acid A (GABAA) receptors are tonically activated by low and consistent levels of ambient GABA, mediating chronic inhibition against neuronal excitability (tonic inhibition) and the modulation of neural ...
Kiyoshi eEgawa, Atsuo eFukuda
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Tonic Inhibition of TRPV3 by Mg2+ in Mouse Epidermal Keratinocytes [PDF]
Journal of Investigative Dermatology, 2012 The transient receptor potential vanilloid 3 channel (TRPV3) is abundantly expressed in epidermal keratinocytes and has important roles in sensory biology and skin health. Mg(2+) deficiency causes skin disorders under certain pathological conditions such as type 2 diabetes mellitus.
Luo, Jialie +3 more
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Molecular Brain, 2011 A tonic form of synaptic inhibition occurs in discrete regions of the central nervous system and has an important role in controlling neuronal excitability.
Yoon Bo-Eun +6 more
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