Crayfish tonic inhibition: prolonged modulation of behavioral excitability by classical GABAergic inhibition [PDF]
The Journal of Neuroscience, 1993 Previous studies have indirectly implicated the two neurotransmitters 5- HT and GABA in mediating tonic inhibition of the crayfish lateral giant (LG) escape reaction. In this study, pharmacological agents were selectively delivered to restricted portions of the abdominal CNS (where LG escape circuitry resides) to assess directly the role of these two ...
E T, Vu, F B, Krasne
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GABA A Receptor-Mediated Tonic Inhibition in Thalamic Neurons [PDF]
The Journal of Neuroscience, 2005 Tonic GABA A receptor-mediated inhibition is typically generated byδ subunit-containing extrasynaptic receptors. Because the δ subunit is highly expressed in the thalamus, we tested whether thalamocortical (TC) neurons of the dorsal lateral geniculate nucleus (dLGN) and ventrobasal complex ...
Cope, David W. +2 more
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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron [PDF]
Experimental Biology and MedicineProlonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural
Zhiqiang Yu +4 more
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Tonic inhibition originates from synapses close to the soma [PDF]
Neuron, 1995 Central neurons are subject to a tonic barrage of randomly occurring spontaneous inhibitory events (mIP-SCs) resulting from the action potential-independent release of gamma-aminobutyric acid (GABA). Do the terminals making synapses onto somatic versus dendritic sites, which arise from specific populations of interneurons, differ in their ability to ...
Soltesz, I, Smetters, D.K, Mody, I
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What roles do tonic inhibition and disinhibition play in the control of motor programs?
Frontiers in Behavioral Neuroscience, 2010 Animals show periods of quiescence interspersed with periods of motor activity. In a number of invertebrate and vertebrate systems, quiescence is achieved by active suppression of motor behavior induced by sensory input or changes in internal state ...
Paul R Benjamin +2 more
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Neurobiology of Disease, 2010 Neurosteroid sensitivity of GABAA receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy.
Karthik Rajasekaran +4 more
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Astrocytes convert network excitation to tonic inhibition of neurons [PDF]
BMC Biology, 2012 Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in balancing excitatory and inhibitory signals in the brain.
Héja László +9 more
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An enigmatic role of tonic inhibition in gabapentin therapy. [PDF]
EBioMedicine, 2019 Reddy DS.
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Potentiation of tonic GABAergic inhibition by activation of postsynaptic kainate receptors
Neuroscience, 2015 Presynaptic kainate-type glutamate ionotropic receptors (KARs) that mediate either the depression or the facilitation of GABA release have been intensively studied. Little attention has been given to the modulation of GABAA receptors (GABAARs) by postsynaptic KARs. Recent studies suggest that two GABAAR populations, synaptic (sGABAAR) and extrasynaptic
L, Jiang, D, Kang, J, Kang
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Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers. [PDF]
J Neurosci, 2016 Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABA A receptors substantially reduced chloride concentration in granule cells due to block of tonic ...
Berglund K +4 more
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