Neurobiology of Disease, 2010 Neurosteroid sensitivity of GABAA receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy.
Karthik Rajasekaran +4 more
doaj +3 more sources
Thalamic distribution and effects of 5-HT2C receptors on tonic GABAA inhibition and absence seizures: implications for treatment [PDF]
Frontiers in PharmacologyIntroductionChildhood absence epilepsy (CAE) is associated with abnormal thalamocortical oscillations and enhanced GABAergic function in the ventrobasal (VB) thalamus, including increased extrasynaptic GABAA receptor–mediated tonic currents in ...
Anna Cavaccini +8 more
doaj +2 more sources
Cell Reports, 2018 Summary: The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson’s disease (PD), the rate and pattern of activity of GP neurons are profoundly altered and ...
Marine Chazalon +10 more
doaj +3 more sources
An enigmatic role of tonic inhibition in gabapentin therapy. [PDF]
EBioMedicine, 2019 Reddy DS.
europepmc +4 more sources
GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Alexander Bryson +2 more
exaly +2 more sources
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]
, 2015 Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi +64 more
core +12 more sources
Tonic inhibition of chemotaxis in human plasma [PDF]
Proceedings of the National Academy of Sciences, 2008 We found exaggerated chemotaxis in plasma treated with EDTA and thought that the EDTA might itself be inhibiting a tonic inhibitor(s) of chemotaxis. Our plasma fractionations suggested that evidence should be sought for a lipid moiety carrying this activity, and on spectrometry (LC-MS-MS together with GC-MS analyses), the biologically active but not ...
Malawista, Stephen E. +3 more
openaire +3 more sources
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Frontiers in Synaptic Neuroscience, 2022 Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses.
Riley T. Paulsen, Brian D. Burrell
doaj +1 more source
Tonic inhibition of chronic pain by neuropeptide Y [PDF]
Proceedings of the National Academy of Sciences, 2011 Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signals. We found that doxycycline-induced conditional in vivo ( Npy tet/tet ) knockdown of NPY produced rapid ...
Brian, Solway +4 more
openaire +2 more sources
A new meaning for “Gin & Tonic”: tonic inhibition as the target for ethanol action in the brain [PDF]
Alcohol, 2007 Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system, it acts on two distinct types of receptor: an ion channel, that is, an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors [GABAARs]) and a G-protein coupled "metabotropic" receptor that is linked to various ...
Istvan, Mody +2 more
openaire +2 more sources