Results 21 to 30 of about 57,250 (276)
Astrocytes convert network excitation to tonic inhibition of neurons [PDF]
BMC Biology, 2012 Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in balancing excitatory and inhibitory signals in the brain.
Héja László +9 more
doaj +4 more sources
Cell Reports, 2018 Summary: The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson’s disease (PD), the rate and pattern of activity of GP neurons are profoundly altered and ...
Marine Chazalon +10 more
doaj +3 more sources
Thalamic distribution and effects of 5-HT2C receptors on tonic GABAA inhibition and absence seizures: implications for treatment [PDF]
Frontiers in PharmacologyIntroductionChildhood absence epilepsy (CAE) is associated with abnormal thalamocortical oscillations and enhanced GABAergic function in the ventrobasal (VB) thalamus, including increased extrasynaptic GABAA receptor–mediated tonic currents in ...
Anna Cavaccini +8 more
doaj +2 more sources
GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Alexander Bryson +2 more
exaly +2 more sources
Direct tonic inhibition of insulin secretion by central nervous system [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 1983 An experimental animal model was developed to investigate the influence of the central nervous system (CNS) on insulin secretion via direct innervation to the pancreas.
D. L. Curry
core +3 more sources
An enigmatic role of tonic inhibition in gabapentin therapy. [PDF]
EBioMedicine, 2019 Reddy DS.
europepmc +4 more sources
Monoamine modulation of tonic GABAA inhibition [PDF]
Reviews in the Neurosciences, 2014 In recent years, it has become evident that many neurotransmitters and endogenous ligands differentially modulate synaptic γ-aminobutyric acid type A receptors (sGABAARs) and extrasynaptic GABAAR (eGABAARs). In this mini-review, we will summarize the available evidence on the ability of the monoamines serotonin (5-HT), noradrenaline (NA), and, in ...
Crunelli, Vincenzo +1 more
openaire +3 more sources
Tonic inhibition of chemotaxis in human plasma [PDF]
Proceedings of the National Academy of Sciences, 2008 We found exaggerated chemotaxis in plasma treated with EDTA and thought that the EDTA might itself be inhibiting a tonic inhibitor(s) of chemotaxis. Our plasma fractionations suggested that evidence should be sought for a lipid moiety carrying this activity, and on spectrometry (LC-MS-MS together with GC-MS analyses), the biologically active but not ...
Malawista, Stephen E. +3 more
openaire +4 more sources
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Frontiers in Synaptic Neuroscience, 2022 Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses.
Riley T. Paulsen, Brian D. Burrell
doaj +1 more source
Tonic inhibition of chronic pain by neuropeptide Y [PDF]
Proceedings of the National Academy of Sciences, 2011 Dramatically up-regulated in the dorsal horn of the mammalian spinal cord following inflammation or nerve injury, neuropeptide Y (NPY) is poised to regulate the transmission of sensory signals. We found that doxycycline-induced conditional in vivo ( Npy tet/tet ) knockdown of NPY produced rapid ...
Brian, Solway +4 more
openaire +2 more sources