Results 11 to 20 of about 54,149 (242)
Frontiers in Neural Circuits, 2014 The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations during subunit assembly give rise to a variety of receptors with different functional properties. This heterogeneity results in variations in GABAergic conductances across
Vallent eLee, Jamie eMaguire
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Homeostatic competition between phasic and tonic inhibition. [PDF]
J Biol Chem, 2013 The GABAA receptors are the major inhibitory receptors in the brain and are localized at both synaptic and extrasynaptic membranes. Synaptic GABAA receptors mediate phasic inhibition, whereas extrasynaptic GABAA receptors mediate tonic inhibition. Both phasic and tonic inhibitions regulate neuronal activity, but whether they regulate each other is not ...
Wu X +7 more
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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron [PDF]
Experimental Biology and MedicineProlonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural
Zhiqiang Yu +4 more
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What roles do tonic inhibition and disinhibition play in the control of motor programs?
Frontiers in Behavioral Neuroscience, 2010 Animals show periods of quiescence interspersed with periods of motor activity. In a number of invertebrate and vertebrate systems, quiescence is achieved by active suppression of motor behavior induced by sensory input or changes in internal state ...
Paul R Benjamin +2 more
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Astrocytes convert network excitation to tonic inhibition of neurons [PDF]
BMC Biology, 2012 Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in balancing excitatory and inhibitory signals in the brain.
Héja László +9 more
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Cell Reports, 2018 Summary: The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson’s disease (PD), the rate and pattern of activity of GP neurons are profoundly altered and ...
Marine Chazalon +10 more
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NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons [PDF]
Frontiers in Synaptic NeuroscienceIntroductionAmbient glutamate is capable of regulating neural excitability and contributes to several brain pathologies. It is well established by experiments on rodent tissue that extrasynaptic glutamate –mainly regulated by astrocytic glutamate uptake-
Béla Márton +8 more
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Brief Dark Exposure Reduces Tonic Inhibition in Visual Cortex. [PDF]
J Neurosci, 2015 Tonic inhibition mediated by extrasynaptic GABAAreceptors (GABARs) sensing ambient levels of GABA can profoundly alter the membrane input resistance to affect cellular excitability. Therefore, regulation of tonic inhibition is an attractive mechanism to control the levels of cortical firing. In cortical pyramidal cells, tonic inhibition is regulated by
Huang S +4 more
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An enigmatic role of tonic inhibition in gabapentin therapy. [PDF]
EBioMedicine, 2019 Reddy DS.
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GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Robert Hatch +2 more
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