Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination [PDF]
Experimental and Molecular MedicineTonic inhibition in cerebellar granule cells is crucial for maintaining information coding fidelity during motor coordination. It arises through both activity-dependent and activity-independent mechanisms, and the interplay between these mechanisms ...
Jea Kwon +7 more
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Chronic Stress Oppositely Regulates Tonic Inhibition in Thy1-Expressing and Non-expressing Neurons in Amygdala [PDF]
Frontiers in Neuroscience, 2020 Chronic or prolonged exposure to stress ranks among the most important socioenvironmental factors contributing to the development of neuropsychiatric diseases, a process generally associated with loss of inhibitory tone in amygdala.
Han-Qing Pan +18 more
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Role of tonic inhibition in associative reward conditioning in Lymnaea [PDF]
Frontiers in Behavioral Neuroscience, 2010 Changes in the strength of excitatory synaptic connections are known to underlie associative memory formation in the molluscan nervous system but less is known about the role of synaptic inhibition.
Vincenzo Marra +5 more
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Frontiers in Neural Circuits, 2014 The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations during subunit assembly give rise to a variety of receptors with different functional properties. This heterogeneity results in variations in GABAergic conductances across
Vallent eLee, Jamie eMaguire
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Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron [PDF]
Experimental Biology and MedicineProlonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural
Zhiqiang Yu +4 more
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Homeostatic competition between phasic and tonic inhibition. [PDF]
J Biol Chem, 2013 The GABAA receptors are the major inhibitory receptors in the brain and are localized at both synaptic and extrasynaptic membranes. Synaptic GABAA receptors mediate phasic inhibition, whereas extrasynaptic GABAA receptors mediate tonic inhibition. Both phasic and tonic inhibitions regulate neuronal activity, but whether they regulate each other is not ...
Wu X +7 more
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Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABAA Receptors in Dentate Granule Neurons [PDF]
Frontiers in Molecular Neuroscience, 2020 GABAA receptors mediate a large fraction of inhibitory neurotransmission in the central nervous system. Two major classes of GABAA receptors are γ2-containing receptors and δ-containing receptors, which are largely located synaptically and ...
Xinguo Lu +6 more
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Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors [PDF]
PharmaceuticalsCell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized
Abraham Rosas-Arellano
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Astrocytes convert network excitation to tonic inhibition of neurons [PDF]
BMC Biology, 2012 Background Glutamate and γ-aminobutyric acid (GABA) transporters play important roles in balancing excitatory and inhibitory signals in the brain.
Héja László +9 more
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Tonic GABAA receptor currents in Cerebellar Purkinje cells of wild-type and DMDmdx mice [PDF]
Scientific ReportsCerebellar Purkinje cells (PCs) fire spontaneously and depend heavily on inhibition to modify their activity. While phasic inhibition is well-described in PCs, the presence and mechanisms of tonic inhibitory currents, low amplitude currents resulting ...
Shaarang Mitra +2 more
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