Methods for recording and measuring tonic GABA¬A receptor-mediated inhibition [PDF]
Frontiers in Neural Circuits, 2013 Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterised in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but ...
Damian eBright, Trevor G. Smart
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Role of tonic inhibition in associative reward conditioning in Lymnaea [PDF]
Frontiers in Behavioral Neuroscience, 2010 Changes in the strength of excitatory synaptic connections are known to underlie associative memory formation in the molluscan nervous system but less is known about the role of synaptic inhibition.
Vincenzo Marra +5 more
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Enhanced tonic GABAA inhibition in typical absence epilepsy [PDF]
Nature Medicine, 2009 The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but impaired gamma-aminobutyric acid (GABA)-ergic inhibition remains an attractive hypothesis.
Errington, Adam C. +28 more
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Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers. [PDF]
J Neurosci, 2016 Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABA A receptors substantially reduced chloride concentration in granule cells due to block of tonic ...
Berglund K +4 more
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Crayfish tonic inhibition: prolonged modulation of behavioral excitability by classical GABAergic inhibition [PDF]
The Journal of Neuroscience, 1993 Previous studies have indirectly implicated the two neurotransmitters 5- HT and GABA in mediating tonic inhibition of the crayfish lateral giant (LG) escape reaction. In this study, pharmacological agents were selectively delivered to restricted portions
ET Vu, FB Krasne
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GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons [PDF]
The Journal of Neuroscience, 2005 Tonic GABAA receptor-mediated inhibition is typically generated by subunit-containing extrasynaptic receptors. Because the subunit is highly expressed in the thalamus, we tested whether thalamocortical (TC) neurons of the dorsal lateral geniculate ...
Cope, David W. +2 more
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The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum [PDF]
Molecular Brain, 2011 A tonic form of synaptic inhibition occurs in discrete regions of the central nervous system and has an important role in controlling neuronal excitability.
Yoon Bo-Eun +6 more
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Tonic inhibition originates from synapses close to the soma [PDF]
Neuron, 1995 Central neurons are subject to a tonic barrage of randomly occurring spontaneous inhibitory events (mIPSCs) resulting from the action potential-independent release of γ-aminobutyric acid (GABA).
Smetters, D.K, Mody, I, Soltesz, I
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What roles do tonic inhibition and disinhibition play in the control of motor programs? [PDF]
Frontiers in Behavioral Neuroscience, 2010 Animals show periods of quiescence interspersed with periods of motor activity. In a number of invertebrate and vertebrate systems, quiescence is achieved by active suppression of motor behavior induced by sensory input or changes in internal state ...
Paul R Benjamin +2 more
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NMDA receptor mediated tonic excitatory currents are elicited by EAAT inhibition on human neocortical pyramidal neurons [PDF]
Frontiers in Synaptic NeuroscienceIntroductionAmbient glutamate is capable of regulating neural excitability and contributes to several brain pathologies. It is well established by experiments on rodent tissue that extrasynaptic glutamate –mainly regulated by astrocytic glutamate uptake-
Béla Márton +8 more
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