Results 61 to 70 of about 1,069,702 (278)
Tonic immobility in two species of Southern African catsharks [PDF]
, 2020 Magister Scientiae (Biodiversity and Conservation Biology) - MSc (Biodiv and Cons Biol)Tonic immobility (TI) can be defined as an unlearned behavioural response described by a physical state of immobility. This behaviour can last from a few seconds up to
Sebastian, Lemόne Margeaux
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PLoS ONE, 2011 GABAergic inhibition in the central nervous system (CNS) can occur via rapid, transient postsynaptic currents and via a tonic increase in membrane conductance, mediated by synaptic and extrasynaptic GABA(A) receptors (GABA(A)Rs) respectively.
Stefanie M Jones, Mary J Palmer
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Tonic excitation or inhibition is set by GABAA conductance in hippocampal interneurons [PDF]
Nature Communications, 2011 Inhibition is a physiological process that decreases the probability of a neuron generating an action potential. The two main mechanisms that have been proposed for inhibition are hyperpolarization and shunting. Shunting results from increased membrane conductance, and it reduces the neuron-firing probability.
Song, Inseon +2 more
openaire +2 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Regulation of output spike patterns by phasic inhibition in cerebellar granule cells
Frontiers in Cellular Neuroscience, 2014 The complex interplay of multiple molecular mechanisms taking part to synaptic integration is hard to disentangle experimentally. Therefore, we developed a biologically realistic computational model based on the rich set of data characterizing the ...
Thierry Ralph Nieus +4 more
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Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Nature Communications, 2021 Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of ...
Baptiste Lamarthée +22 more
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Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Errington, Adam C. +2 more
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Craig's Golden Tonic for the blood
, 2023 Trade card/ink blotter advertising Craig's Golden Tonic, a remedy prepared by Craig's Golden Tonic Co ...
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Neurobiology of Disease, 2015 In many synapses of the CNS, mobile zinc is packaged into glutamatergic vesicles and co-released with glutamate during neurotransmission. Following synaptic release, the mobilized zinc modulates ligand- and voltage-gated channels and receptors ...
Tamara Perez-Rosello +4 more
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