Results 161 to 170 of about 112,577,777 (211)

Locating GABA in GABA receptor binding sites

Biochemical Society Transactions, 2009
The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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GABA and GABA receptors in invertebrates

Seminars in Neuroscience, 1991
Abstract GABA is the major inhibitory transmitter at invertebrate synapses in both the central and peripheral nervous systems. The receptors for GABA are well characterised electrophysiologically in a wide variety of invertebrate organisms but their biochemical and pharmacological profiles are less well defined. In general invertebrate GABA receptors
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GABA-receptors in peripheral tissues

Life Sciences, 1990
Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
J, Ong, D I, Kerr
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A diversity of GABA receptors in the retina

Seminars in Cell & Developmental Biology, 1998
GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
P D, Lukasiewicz, C R, Shields
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Bicuculline and Central GABA Receptors

Nature, 1970
WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
D R, Curtis, A W, Duggan, D, Felix, G A, Johnston   +3 more
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Pharmacology of insect GABA receptors

Neurochemical Research, 1991
A GABA-operated Cl- channel that is bicuculline-insensitive is abundant in the nervous tissue of cockroach, in housefly head preparations and thorax/abdomen preparations, and in similar preparations from several insect species. Bicuculline-insensitive GABA-operated Cl- channels, which are rare in vertebrates, possess sites of action of benzodiazepines,
Sattelle, David B., Lummis, Sarah C R, Wong, James F H, Rauh, James J.   +3 more
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Benzodiazepine interactions with GABA receptors

Neuroscience Letters, 1984
Benzodiazepines (BZs) produce most, if not all, of their pharmacological actions by specifically enhancing the effects of endogenous and exogenous GABA that are mediated by GABAA receptors. This potentiation consists in an increase of the apparent affinity of GABA for increasing chloride conductance without increase in its efficacy and, on the single ...
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GABA-B Receptors in Drosophila

2010
Drosophila melanogaster, the "fruit fly," is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively
Hari, Manev, Svetlana, Dzitoyeva
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GABA Receptor molecules of insects

1993
Receptors for 4-aminobutyric acid (GABA) have been identified in both central and peripheral nervous systems of several invertebrate phyla. To date, much of the information derived from physiological and biochemical studies on insect GABA receptors relates to GABA-gated chloride channels that show some similarities with vertebrate GABAA receptors. Like
Anthony, N. M., Harrison, J. B., Sattelle, D. B.   +2 more
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Presynaptic GABA Receptors

Annals of the New York Academy of Sciences, 1990
P C, Waldmeier, P A, Baumann
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