Results 281 to 290 of about 604,542 (323)
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A diversity of GABA receptors in the retina
Seminars in Cell & Developmental Biology, 1998GABA, a major inhibitory transmitter in the vertebrate retina, plays important roles in processing visual information. There are three functional families of retinal GABA receptors, the ionotropic GABAA and GABAC receptors and the metabotropic GABAB receptor. GABAC receptors are enriched in the retina, compared to other parts of the CNS.
Peter D. Lukasiewicz, Colleen R. Shields
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Locating GABA in GABA receptor binding sites
Biochemical Society Transactions, 2009The Cys-loop family of ligand-gated ion channels contains both vertebrate and invertebrate members that are activated by GABA (γ-aminobutyric acid). Many of the residues that are critical for ligand binding have been identified in vertebrate GABAA and GABAC receptors, and specific interactions between GABA and some of these residues have been ...
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2007
γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors have been identified, GABAA and GABAB. GABAA receptors are pentameric ligand-gated chloride-ion channels, whereas GABAB receptors are heterodimeric G protein-coupled sites.
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GABA-receptors in peripheral tissues
Life Sciences, 1990Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines, and non-neural tissues such as smooth muscle and the female reproductive system. In all these, both GABAA- and GABAB-receptor types are found, with good evidence for a physiological role in the ...
Jennifer Ong, David I.B. Kerr
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GABA Receptors and Phospholipids
1978The sodium-independent binding of GABA to certain membrane preparations from rat brain exhibits many of the properties of the interaction of GABA with postsynaptic receptors anticipated from in vivo studies (see papers by Enna and Olsen, this meeting).
S. M. E. Kennedy, Graham A.R. Johnston
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GABA-B Receptors in Drosophila
2010Drosophila melanogaster, the "fruit fly," is being increasingly used as an experimental model in neurosciences, including neuropharmacology. The advantages of Drosophila over typical mammalian models in neuropharmacology include better access to genetic manipulation and the availability of almost unlimited numbers of experimental subjects at relatively
Svetlana Dzitoyeva, Hari Manev
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Nonsynaptic Receptors for GABA and Glutamate
Current Topics in Medicinal Chemistry, 2006The concept of nonsynaptic communication between neurons, once a heretic idea, has become a self-evident fact during the almost forty years since its original discovery. In this review we investigate whether the archetypical synaptic transmitters of the central nervous system, Glu and GABA, can operate via nonsynaptic transmission.
Arpad Mike, E.S. Vizi
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Bicuculline and Central GABA Receptors
Nature, 1970WE are unable to accept the implication by Krnjevic and his associates1 that we erred in reporting2 bicuculline to be a relatively specific antagonist of γ-aminobutyric acid (GABA) in the central nervous system of the cat.
David R. Curtis +3 more
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GABA and Its Receptors in Epilepsy
2004Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the mammalian brain. It acts through 2 classes of receptors, GABAA receptors that are ligand-operated ion channels and the G-protein-coupled metabotropic GABAB receptors. Impairment of GABAergic transmission by genetic mutations or application of GABA receptor antagonists ...
Susanne Pirker +3 more
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Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Sergej Kolbaev +2 more
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