Results 31 to 40 of about 177,108 (289)

Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft

open access: yesNeurobiology of Disease, 2018
GABA is a widely distributed inhibitory neurotransmitter. GABA-A receptors are hetero-pentameric channels assembled in multiple combinations from 19 available subunits; this diversity mediates phasic and tonic inhibitory synaptic potentials. Whereas GABA-
Abraham Rosas-Arellano   +7 more
doaj   +1 more source

The potential role of pancreatic γ-aminobutyric acid (GABA) in diabetes mellitus: A critical reappraisal

open access: yesInternational Journal of Preventive Medicine, 2021
Background: Diabetes mellitus (DM) is an endocrine disorder characterized by hyperglycemia, polyuria, polydipsia, and glucosuria. γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system (CNS) of humans and other mammals.
Hayder M Al-Kuraishy   +5 more
doaj   +1 more source

Emerging neurotrophic role of GABAB receptors in neuronal circuit development [PDF]

open access: yes, 2013
The proper development of highly organized structures in the central nervous system is a complex process during which key events – neurogenesis, migration, growth, differentiation, and synaptogenesis – have to take place in an appropriate manner to ...
Christophe Porcher, Jean-Luc Gaiarsa
core   +1 more source

Stimulation of TM3 Leydig cell proliferation via GABAA receptors: A new role for testicular GABA

open access: yesReproductive Biology and Endocrinology, 2004
The neurotransmitter gamma-aminobutyric acid (GABA) and subtypes of GABA receptors were recently identified in adult testes. Since adult Leydig cells possess both the GABA biosynthetic enzyme glutamate decarboxylase (GAD), as well as GABAA and GABAB ...
Krieger Annette   +4 more
doaj   +1 more source

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

open access: yes, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Kullmann, D.M.   +4 more
core   +1 more source

Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut–Brain Axis

open access: yesBiomedicines, 2023
Research conducted on individuals with depression reveals that major depressive disorders (MDDs) coincide with diminished levels of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) in the brain, as well as modifications in the subunit ...
Timur Liwinski   +3 more
doaj   +1 more source

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

open access: yes, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source

Co-operative Effect Between γ-Aminobutyric Acid A Receptors and Central-Type Benzodiazepine Receptors on Amylase Release in Rat Parotid Acinar Cells

open access: yesJournal of Pharmacological Sciences, 2010
We investigated the inhibitory role of γ-aminobutyric acid A (GABA A ) receptors on amylase release and the evidence for functional coupling with central-type benzodiazepine receptors in rat parotid acinar cells.
Migiwa Okubo, Mitsuru Kawaguchi
doaj   +1 more source

Role of GABA and its receptors in anti-adipogenesis in cultured adipocytes [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2020
Health benefits of GABA and GABA-enriched foods via anti-obesity activity have been demonstrated in animals. However, the functional roles of GABA especially as non-neurotransmitter in adipocytes have not been thoroughly clarified.
Kanittaporn Trisat   +2 more
doaj   +1 more source

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