Results 11 to 20 of about 100,399 (194)

GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.

PLoS ONE, 2012
GABA is more than the main inhibitory neurotransmitter found in the adult CNS. Several studies have shown that GABA regulates the proliferation of progenitor and stem cells.
Henrik Ring, Suresh Kumar Mendu, Shahrzad Shirazi-Fard, Bryndis Birnir, Finn Hallböök   +4 more
doaj   +1 more source

Neuronal Gamma-Aminobutyric Acid (GABA) Type A Receptors Undergo Cognate Ligand Chaperoning in the Endoplasmic Reticulum by Endogenous GABA

Frontiers in Cellular Neuroscience, 2015
GABAA receptors mediate fast inhibitory neurotransmission in the brain. Dysfunction of these receptors is associated with various psychiatric/neurological disorders and drugs targeting this receptor are widely used therapeutic agents.
Ping eWang, Randa S Eshaq, Charlie K. Meshul, Charlie K. Meshul, Cynthia eMoore, Cynthia eMoore, Rebecca L. Hood, Rebecca L. Hood, Nancy Jo Leidenheimer   +8 more
doaj   +1 more source

Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. [PDF]

PLoS ONE, 2012
In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength.
Viviana Valdés, José Ignacio Valenzuela, Daniela A Salas, Matías Jaureguiberry-Bravo, Carolina Otero, Christina Thiede, Christoph F Schmidt, Andrés Couve   +7 more
doaj   +1 more source

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

Biomolecules, 2023
The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors. Interestingly, the PAM effects of ALLO are strongly enantioselective, whereas those of PREG are not.
Hiroki Tateiwa, Satyanarayana M. Chintala, Ziwei Chen, Lei Wang, Fatima Amtashar, John Bracamontes, Allison L. Germann, Spencer R. Pierce, Douglas F. Covey, Gustav Akk, Alex S. Evers   +10 more
doaj   +1 more source

Conditional gene deletion reveals functional redundancy of GABA_B receptors in peripheral nociceptors in vivo

Molecular Pain, 2009
Background γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bettler Bernhard, Tegeder Imgard, Brugger Stefan, Agarwal Nitin, Gangadharan Vijayan, Kuner Rohini, Kurejova Martina   +6 more
doaj   +1 more source

Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs

Cell Reports, 2023
Summary: We describe a retrograde synaptic signal at the C. elegans GABAergic neuromuscular junction. At this synapse, GABA release is controlled by two voltage-activated calcium channels (UNC-2/CaV2 and EGL-19/CaV1), and muscle responses are mediated by
Jian Zhao, Luna Gao, Stephen Nurrish, Joshua M. Kaplan   +3 more
doaj   +1 more source

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

PLoS ONE, 2011
BackgroundGABA(A) receptors are members of the Cys-loop family of neurotransmitter receptors, proteins which are responsible for fast synaptic transmission, and are the site of action of wide range of drugs.
Daniel W Wheeler, Andrew J Thompson, Federico Corletto, Jill Reckless, Justin C T Loke, Nicolas Lapaque, Andrew J Grant, Pietro Mastroeni, David J Grainger, Claire L Padgett, John A O'Brien, Nigel G A Miller, John Trowsdale, Sarah C R Lummis, David K Menon, John S Beech   +15 more
doaj   +1 more source

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. [PDF]

PLoS ONE, 2016
The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and cysteine, and tested with GABA, some representative partial agonists and antagonists. Thr244 has
Moawiah M Naffaa, Nathan Absalom, V Raja Solomon, Mary Chebib, David E Hibbs, Jane R Hanrahan   +5 more
doaj   +1 more source

GABA-A and GABA-B Receptors in Filial Imprinting Linked With Opening and Closing of the Sensitive Period in Domestic Chicks (Gallus gallus domesticus)

Frontiers in Physiology, 2018
Filial imprinting of domestic chicks has a well-defined sensitive (critical) period lasting in the laboratory from hatching to day 3. It is a typical model to investigate the molecular mechanisms underlying memory formation in early learning. We recently
Naoya Aoki, Shinji Yamaguchi, Toshiyuki Fujita, Chihiro Mori, Chihiro Mori, Eiko Fujita, Toshiya Matsushima, Koichi J. Homma   +7 more
doaj   +1 more source