Results 141 to 150 of about 2,453,144 (355)

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Genetic Downregulation of GABA_B Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

Cells
GABAergic signaling and GABAB receptors play crucial roles in regulating the physiology of oligodendrocyte-lineage cells, including their proliferation, differentiation, and myelination.
Davide Gobbo, Phillip Rieder, Li-Pao Fang, Emeline Buttigieg, Moritz Schablowski, Elisa Damo, Nathalie Bosche, Eleonora Dallorto, Pascal May, Xianshu Bai, Frank Kirchhoff, Anja Scheller   +11 more
doaj   +1 more source

Advances in Startpoint Theory for quasi-pseudometric spaces [PDF]

arXiv, 2014
This paper presents some startpoint (endpoint, fixed point) theorems for mutli-valued maps that generalize recent results proved by Y. U. Gaba \cite{rico, ricoo}.
arxiv  

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Nitrocyclopropanes as Valuable Building Blocks in Organic Synthesis and Biology: Exploring the Origin of the Nitro Group

Chemistry – A European Journal, Volume 31, Issue 20, April 4, 2025.
This review summarizes the synthetic methodologies of the nitro‐substituted Donor‐Acceptor cyclopropanes (NCPs). Particularly from nitroalkenes including the Michael Initiated Ring Closure and the Oxidative Ring Closure of Michael Adducts, from Diazo Compounds bearing Nitro Group, from Nitromethane and its Derivatives; and after Oxidation of ...
Andriani G. Chaidali, Michael A. Terzidis, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A

Journal of Biomedical Science, 2012
Abstact Background Gamma amino butyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tones that counter balances neuronal excitation. When this balance is perturbed, seizures may ensue. Methods In
Mathew Jobin, Balakrishnan Savitha, Antony Sherin, Abraham Pretty, Paulose CS   +4 more
doaj   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
A Sali, A Triller, B Frolund, C Notredame, CG Wermuth, CL Padgett, CM Houston, D Belelli, DA Wagner, DM Kullmann, E Sigel, EF Pettersen, EG Steward, EM Schneider Gasser, EO Mann, F Iqbal, G Jones, G Nyiri, H Kiefer, H Mohler, H Zhong, J Amin, J Isaacson, JG Newell, JG Newell, JH Holden, JJ Chambers, JM Fritschy, JQ Kang, JT Kittler, K Ramamoorthi, L Dubinsky, LB Kier, M Ernst, M Heaulme, M Mortensen, M Mortensen, M Mortensen, M Mortensen, MA Simmonds, MC Ashby, N Zacharias, NG Bowery, O Arunlakshana, P Thomas, PS Miller, R Sathyapriya, RW Olsen, S Ueno, SB Hansen, SC Lummis, SE Westh-Hansen, SE Westh-Hansen, SJ Moss, T Klausberger, T Klausberger, TC Turek, U Resch-Genger, Y Bogdanov, Y Chang   +59 more
core   +1 more source

Wetlands as environments of early human occupation: A new classification for freshwater palaeowetlands

The Depositional Record, EarlyView.
A new classification for inland freshwater palaeowetlands to be used in the field or core laboratory by sedimentologists, providing examples from the Guadix Basin (southern Spain). Abstract Present wetlands have proven to be delicate, biodiverse ecosystems, that are natural sinks for CO2 and act as good indicators for climate changes.
S. Pla‐Pueyo, E. H. Gierlowski‐Kordesch   +1 more
wiley   +1 more source

Activation of GABA_B receptors inhibits protein kinase B /Glycogen Synthase Kinase 3 signaling

Molecular Brain, 2012
Accumulated evidence has suggested that potentiation of cortical GABAergic inhibitory neurotransmission may be a key mechanism in the treatment of schizophrenia. However, the downstream molecular mechanisms related to GABA potentiation remain unexplored.
Lu Frances Fangjia, Su Ping, Liu Fang, Daskalakis Zafiris J   +3 more
doaj   +1 more source

Fixed point theorems in $G$-metric space [PDF]

arXiv, 2017
In this article, we present a new type of fixed point for single valed mapping in a $G$-complete $G$-metric space.
arxiv