Results 141 to 150 of about 2,475,949 (282)
Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
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Chemistry &Biodiversity, EarlyView.ABSTRACT Maize is an important crop worldwide with approximately 1200 million tons consumed and a market size worth $143 billion. Environmental stress influence production of crops and mitigating these ensures optimum production. Dicarboxylic acids are known as emulsifying agents that mitigate various stresses in plants.
Mhlonipheni Msomi +3 more
wiley +1 more source
Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application
Chemistry &Biodiversity, EarlyView.ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade +4 more
wiley +1 more source
NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES
ChemMedChem, Accepted Article.Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti +4 more
wiley +1 more source
Chronic-moderate ethanol exposure of L(tk-) cells expressing ? 4? 3? GABAA receptors reduces potency of allopregnanolone potentiation of GABA-evoked inward currents: Possible role of PKC [PDF]
, 2012 Aim: To investigate the effect of chronic-moderate ethanol (CME) treatment upon direct activation and allosteric modulation of GABAA receptors, and to assess the sensitivity of these parameters to PKC inhibition in control and ethanol-treated cells ...
Barrett, I.D., Kelley, Stephen P.
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Clinical Pharmacology &Therapeutics, EarlyView.Selective N‐methyl‐D‐aspartate receptor subunit 2b negative allosteric modulators (NR2B NAMs) are being explored as potential new treatment options for major depressive disorder (MDD). This Phase Ib, randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted in adults (N = 59) with moderate‐to‐severe MDD and insufficient response ...
Roger S. McIntyre +9 more
wiley +1 more source
The Depositional Record, EarlyView.A new classification for inland freshwater palaeowetlands to be used in the field or core laboratory by sedimentologists, providing examples from the Guadix Basin (southern Spain). Abstract Present wetlands have proven to be delicate, biodiverse ecosystems, that are natural sinks for CO2 and act as good indicators for climate changes.
S. Pla‐Pueyo +1 more
wiley +1 more source
Journal of Pharmacology and Experimental Therapeutics, 2018 Shu-Hui Chuang, D. Reddy
semanticscholar +1 more source
Seminars in epileptology: How to diagnose status epilepticus in adults and children
Epileptic Disorders, EarlyView.Abstract Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation and mechanisms leading to metabolic and inflammatory derangements with increased risk of brain damage, alterations of neural networks, and potentially life‐threatening systemic complications ...
M. Leitinger +12 more
wiley +1 more source
The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala. [PDF]
, 2009 Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region.
Cook, James M +10 more
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