Results 231 to 240 of about 2,475,949 (282)

Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling. [PDF]

Cancer Metab
Dong J, Wu Y, Che J, He Z, Zhang J.
europepmc   +1 more source

Neuroprotective Efficacy of Microwave‐Assisted Synthetized 2‐(5‐Cyclopropyl‐6‐Thioxo‐1,3,5‐Thiadiazinan‐3‐Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole‐Induced Mice Model

ChemistryOpen, EarlyView.
Microwave synthesis yielded 2‐(5‐cyclopropyl‐6‐thioxo‐1,3,5‐thiadiazinan‐3‐yl)acetic acid, confirmed by infrared, nuclear magnetic resonance, and electron ionization mass spectrometry. In a pentylenetetrazole‐induced epilepsy model, it countered oxidative stress by boosting antioxidant enzymes (catalase, peroxidase, superoxide dismutase, glutathione ...
Tahir Iqbal, Murad A. Mubaraki, Ahmad Khushal, Amena Arif, Fozia Fozia, Shahid Ali Shah, Ijaz Ahmad, Rasool Khan, Najeeb Ur Rehman, Ziaullah Ziaullah   +9 more
wiley   +1 more source

Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring. [PDF]

Transl Psychiatry
Li M, Qiao Z, Li J, Zhou H, Huang D, Cai Y, Li X, Zhang Z, Zhou J, Zhou J.   +9 more
europepmc   +1 more source

Abrupt and Severe Onset of Dystonia, Chorea and Hemiplegic Episodes in a Young Boy with a Novel Heterozygous Missense Variant in the GTPase Domain of RHOBTB2

Movement Disorders Clinical Practice, EarlyView.
Phuong T. Hoang, Ian O. Bledsoe, Marta San Luciano   +2 more
wiley   +1 more source

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

ChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas, Md. Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J. Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam   +8 more
wiley   +1 more source

GABA_B receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation. [PDF]

Ann Med
Wu T, Sun XY, Cao J, Tong K, Hao JR, Sun N, Gao C.   +6 more
europepmc   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

PROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca, Simona Masia, Piero Giustacchini, Sergio Uzzau   +3 more
wiley   +1 more source

Tea and Its Active Ingredients in Preventing and Alleviating Depression: A Comprehensive Review. [PDF]

Foods
Xiao S, Li Y, Jiang H, Hou S, Wang Y, Wang D, Teng J.   +6 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

From the different pathogenesis of epileptogenesis: vitamins as an adjunctive treatment for epilepsy. [PDF]

Acta Epileptol
Sun W, Wang Y, Xiao B, Luo Z.
europepmc   +1 more source