Results 251 to 260 of about 2,453,144 (355)

Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP. [PDF]

Neurochem Res
Harsing LG, Szénási G, Fehér B, Miklya I.   +3 more
europepmc   +1 more source

Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles

Integrative Zoology, EarlyView.
This study used a tail‐pinching model during development to simulate mechanical pain experienced by pups in high‐social mandarin voles (Microtus mandarinus). Subsequently, brush‐like positive tactile stimuli were applied to the backs of the mandarin voles.
Yahan SUN, Jiayu XIAO, Luoman LI, Haiwei NIU, Yiting ZHU, Lu LI, Wei QIAN, Yin LI, Lizi ZHANG, Yishan QU, Yuting BAI, Xiao HAN, Kaizhe HUANG, Zhixiong HE, Fadao TAI   +14 more
wiley   +1 more source

GABA_B Receptor: Structure, Biological Functions, and Therapy for Diseases. [PDF]

MedComm (2020)
Xie W, Li Y, Wang X, Blokhina E, Krupitsky E, Vetrova M, Hu J, Yuan TF, Chen J, Wang H, Chen X.   +10 more
europepmc   +1 more source

Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging

Aging Cell, Volume 24, Issue 5, May 2025.
Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda, Ana Paula Bergamo Araujo, Danilo Bilches Medinas, Flávia Carvalho Alcantara Gomes   +3 more
wiley   +1 more source

Pharmacological mechanism and clinical application of ciprofol. [PDF]

Front Pharmacol
Zhou J, Wang L, Zhong Z, Yuan L, Huang J, Zou P, Cao X, Peng D, Liao B, Zeng J.   +9 more
europepmc   +1 more source

Transcriptional Heterogeneity and Differential Response of Rod Photoreceptor Pathway Uncovered by Single‐Cell RNA Sequencing of the Aging Mouse Retina

Aging Cell, Volume 24, Issue 5, May 2025.
Healthy aging is accompanied by transcriptional dysregulation in retinal cells, leading to alterations in key molecular pathways and cellular responses, with the scotopic pathway being particularly affected. We show that rod photoreceptors, essential for initiating scotopic (low‐light) vision, exhibit selective vulnerability to aging‐associated ...
Laura Campello, Matthew J. Brooks, Benjamin R. Fadl, Hyo Sub Choi, Soumitra Pal, Anand Swaroop   +5 more
wiley   +1 more source

Comparative study of the effects of prenatal sevoflurane exposure at different cortical stages on forebrain development and maturation in offspring. [PDF]

Front Neurosci
Wang T, Weng H, Li Y.
europepmc   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

<i>Bifidobacterium adolescentis PRL2019</i> in Pediatric Irritable Bowel Syndrome: A Multicentric, Randomized, Double-Blind, Placebo-Controlled Trial. [PDF]

Microorganisms
Giorgio V, Quatrale G, Mennini M, Piccirillo M, Furio S, Stella G, Ferretti A, Parisi P, Evangelisti M, Felici E, Quitadamo P, Di Nardo G.   +11 more
europepmc   +1 more source