Results 261 to 270 of about 2,530,726 (346)

Oxidative Stress-Mediated Neuroinflammation in the Pathophysiology of Schizophrenia. [PDF]

Int J Mol Sci
Trubalski M, Markiewicz-Gospodarek A, Żerebiec M, Poleszak J, Szczotka M, Markiewicz R, Łoza B, Szymańczyk S.   +7 more
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Nitrogen waste metabolism as a locus of nitrergic co-transmission in the brain. [PDF]

Front Behav Neurosci
Bedont JL.
europepmc   +1 more source

Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Subsets of midbrain dopamine (DA) neurons express the vesicular glutamate transporter VGLUT2 and can release the excitatory neurotransmitter glutamate. VGLUT2+ DA neurons of the substantia nigra pars compacta (SNc) were shown to be more resistant to neurodegeneration in animal models of Parkinson's disease (PD ...
Sivakumar Srinivasan, Christian Pifl, Thomas Steinkellner   +2 more
wiley   +1 more source

Polymorphic variants in GABA-A receptor and their association with epilepsy and drug resistance: A North Indian cohort study. [PDF]

World J Psychiatry
Dabla PK, Singh S, Viswas A, Gupta S, Yadav M, Sonkar SC, Koner BC, Serdarevic N.   +7 more
europepmc   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Molecular Mechanisms of Emerging Antidepressant Strategies: From Ketamine to Neuromodulation. [PDF]

Int J Mol Sci
Kowalczyk M, Aebisher D, Szpara J, Czech S, Bartusik-Aebisher D, Henrykowska G.   +5 more
europepmc   +1 more source

Distinctive GABA A receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer. [PDF]

Sci Rep
Khodaei M, Hosseinmardi N, Sirati-Sabet M, Sahranavard S, Shahmohammadi MR, Salami S.   +5 more
europepmc   +1 more source

β₂E153 Residue at Loop B of GABA_AR Is Involved in Agonist Stabilization and Gating Properties. [PDF]

Int J Mol Sci
Michałowski MA, Brzóstowicz A, Mozrzymas JW.   +2 more
europepmc   +1 more source