Results 271 to 280 of about 2,530,726 (346)
The role of GABAergic receptors in acute, subacute, and withdrawal syndrome on pain and seizure thresholds in mice: A connection to mitochondrial function and oxidative stress in the brain. [PDF]
Toxicol RepJahani R +4 more
europepmc +1 more source
Psychedelic Modulation of Excitation/Inhibition Balance: A Dual-Phase Neurodevelopmental Model. [PDF]
ACS Chem NeurosciKandilakis CL, Papatheodoropoulos C.
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Decoding the structural and functional diversity of GABA<sub>A</sub> receptors: from ensemble logic to therapeutic opportunities. [PDF]
Front PharmacolTreviño M +7 more
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Glia, 1994
AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
D D, Fraser +2 more
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AbstractGABA receptors are distributed widely throughout the central nervous system on a variety of cell types. It has become increasingly clear that astrocytes, both in cell culture and tissue slices, express abundant GABAA receptors. In astrocytes, GABA activates Cl−‐specific channels that are modulated by barbiturates and benzodiazepines; however ...
D D, Fraser +2 more
openaire +2 more sources
GABA-receptive microglia selectively sculpt developing inhibitory circuits
Cell, 2020Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown ...
Emilia Favuzzi +12 more
semanticscholar +1 more source
Life Sciences, 2003
A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
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A number of important drugs act on GABA(A) receptors, pentameric GABA-gated chloride channels assembled from among 19 known subunits. In trying to discover the roles in the brain of the subunits and their combinations, with the goal of developing more selective drugs, one tool has been to reduce expression of the subunits and examine the functional ...
openaire +2 more sources
Neurochemical Research, 1978
Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
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Physiologic-pharmacologic studies in vivo and with tissue cultures have revealed that synaptic GABA receptors exist in the vertebrate CNS. The GABA antagonist, bicuculline, can be used to detect synaptic GABA receptors in both the presence and absence of Na+, even though GABA binding to cerebral subcellular fractions occurs mainly to transport (uptake)
openaire +2 more sources
Trends in Pharmacological Sciences, 2000
In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an early suggestion by Graham ...
Joachim Bormann
semanticscholar +3 more sources
In the conventional view, GABA acts at either ionotropic GABAA or metabotropic GABAB receptors. Recently, novel ionotropic GABA receptors that are composed of rho-subunits have been identified in the vertebrate retina. These bicuculline- and baclofen-insensitive GABA receptors are frequently called GABAC, following an early suggestion by Graham ...
Joachim Bormann
semanticscholar +3 more sources
Presynaptic Ionotropic GABA Receptors
2007Following the classical work on presynaptic inhibition in the spinal cord, recent work has revealed an astonishing abundance and diversity of presynaptic ionotropic GABA receptors. While modern techniques allow for detailed studies at the cellular and molecular level in almost all regions of the CNS, our understanding of the function of such receptors ...
Andreas, Draguhn +2 more
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1990
Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
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Comparaison des recepteurs GABA ergiques neuronaux des insectes avec ceux des vertebres apres analyse des liaisons de differents agents ...
openaire +2 more sources