Results 271 to 280 of about 2,453,144 (355)

Neuropathological and cerebrospinal fluid correlates of choroid plexus inflammation in progressive multiple sclerosis

Brain Pathology, EarlyView.
Graphical representation of the widespread white matter (blue color mask) and grey matter (cortical and deep grey matter; red color mask) demyelination in MS cases characterized by substantial inflammation of the CP (A). The presence of lesions was mainly associated with periventricular white matter and hippocampus areas (A).
R. Magliozzi, S. Hametner, M. Mastantuono, A. Mensi, M. Karimian, L. Griffiths, L. M. Watkins, A. Poli, G. M. Berti, E. Barusolo, B. Bellini, S. Rossi, D. Gveric, J. A. Stratton, K. Akassoglou, S. Magon, R. Nicholas, R. Reynolds, O. W. Howell, S. Monaco   +19 more
wiley   +1 more source

Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period. [PDF]

Front Cell Neurosci
Pan M, Ye J, Yan Y, Chen A, Li X, Jiang X, Wang W, Meng X, Chen S, Gu Y, Shi X.   +10 more
europepmc   +1 more source

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease

Brain Pathology, EarlyView.
(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma, Steve Gentleman, David Trevor Dexter, Ilse Sanet Pienaar   +3 more
wiley   +1 more source

Anti-Hyperalgesic Effect of Isopulegol Involves GABA and NMDA Receptors in a Paclitaxel-Induced Neuropathic Pain Model. [PDF]

Pharmaceuticals (Basel)
Martins D, Acha B, Cavalcante M, Pereira S, Viana A, Pinheiro-Neto FR, Mendes P, Dittz-Júnior D, Oliveira F, Ventura T, Lobo MDG, Ferreirinha F, Correia-de-Sá P, Almeida F.   +13 more
europepmc   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

The impact of GABA and GABAergic pathway in polycystic ovary syndrome: a systematic review. [PDF]

Obstet Gynecol Sci
Motafeghi F, Amiri M, Noroozzadeh M, Tehrani FR.   +3 more
europepmc   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Postbiotic potential of Lactococcus lactis CNCM I-5388 in alleviating visceral pain in female rat through GABA production: The innovative concept of the "active-GAD bag". [PDF]

FASEB J
Gomes P, Laroute V, Beaufrand C, Bézirard V, Aubry N, Liebgott C, Koper JEB, Parent E, Bosco N, Ballet N, Legrain-Raspaud S, Daveran-Mingot ML, Theodorou V, Cocaign-Bousquet M, Eutamene H, Mercier-Bonin M.   +15 more
europepmc   +1 more source

Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule‐based mitochondrial transport disorder to morphine tolerance

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li, Jie Liu, Jie Ju, Xiaoling Peng, Wei Zhao, Jihao Ren, Xiaoqian Jia, Jihong Wang, Ye Tu, Feng Gao   +9 more
wiley   +1 more source

Current insights and prospects for the pathogenesis and treatment of clinical manifestations associated with Down syndrome through neurotransmitter, inflammatory, and oxidative stress pathways. [PDF]

Front Pharmacol
Alasmari F, Ahmad A, Alsanea S, Hammad AM, Al-Qerem W.   +4 more
europepmc   +1 more source