Results 291 to 300 of about 2,453,144 (355)

Preferential superficial cortical layer activation during seizure propagation

Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.
Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya, Shinnosuke Shiono, Chengsan Sun, Edward Perez‐Reyes, Jaideep Kapur   +4 more
wiley   +1 more source

Synthesis and Evaluation of a Novel Zuranolone Analog with High GABA_A Receptor PAM Activity and Excellent Pharmacokinetic Profiles. [PDF]

Molecules
Yang Y, Deng X, Xu H, Chen D, Zhao F, Yang H, Wang W, Sha C, Ma M, Zhang G, Ye L, Tian J.   +11 more
europepmc   +1 more source

The cerebellum in epilepsy

Epilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder, Rebecca Kerestes, Puneet Opal, Maria Marchese, Orrin Devinsky   +4 more
wiley   +1 more source

The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep. [PDF]

Mediators Inflamm
Zhu W, Gong A, Zhang B, Cheng H, Huang L, Wu X, Zhang D, Dai W, Li S, Xu H.   +9 more
europepmc   +1 more source

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam [PDF]

, 2018
Akk, Gustav, Cao, Lily Q, Chakrabarti, Shampuma, Evers, Alex S, Germann, Allison L, Mennerick, Steven, Montana, Michael C, Shin, Daniel J, Wozniak, David F, Yuede, Carla M   +9 more
core   +1 more source

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

Regulation of neutrophil migration in acute pulmonary inflammation by extraneuronal α1 gamma-aminobutyric acid_A receptors. [PDF]

Cell Death Dis
Fuhr A, Roediger R, Simelitidis M, Gamper-Tsigaras J, Templin M, Kormann M, Antkowiak B, Rudolph U, Köhler D, Rosenberger P, Ngamsri KC, Konrad FM.   +11 more
europepmc   +1 more source

Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant. [PDF]

Brain
Minere M, Mortensen M, Dorovykh V, Warnes G, Nizetic D, Smart TG, Hannan SB.   +6 more
europepmc   +1 more source

Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations. [PDF]

Children (Basel)
Stafstrom CE, Shao LR.
europepmc   +1 more source