Results 61 to 70 of about 2,467,434 (333)

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia

Molecular Pain, 2009
Background Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ...
Lowenstein Pedro, Puntel Mariana, Liu Chunyan, Maechler Pierre, Rubi Blanca, Sundberg Christopher, Ohara Peter T, Vit Jean-Philippe, Castro Maria, Jasmin Luc   +9 more
doaj   +1 more source

Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]

, 2004
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core   +1 more source

A photoswitchable GABA receptor channel blocker [PDF]

British Journal of Pharmacology, 2019
Background and PurposeAnion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharmacological profiles, and localization.
Franck Peiretti, Karin Rustler, Alexandre Gomila-Juaneda, Daniel Wutz, Mercedes Alfonso-Prieto, Mercedes Alfonso-Prieto, Pau Gorostiza, Alba Nin-Hill, Burkhard König, Antoni Bautista-Barrufet, Carme Rovira, Carme Rovira, Elena Petukhova, Galyna Maleeva, Petra Scholze, Piotr Bregestovski, Piotr Bregestovski   +16 more
openaire   +6 more sources

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy

Journal of Experimental Pharmacology, 2021
Slobodan M Janković,1 Miralem Dješević,2 Snežana V Janković1 1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 2Cardiology Department, Private Policlinic Center Eurofarm, Sarajevo, Bosnia and HercegovinaCorrespondence ...
Janković SM, Dješević M, Janković SV
doaj  

Emerging neurotrophic role of GABAB receptors in neuronal circuit development [PDF]

, 2013
The proper development of highly organized structures in the central nervous system is a complex process during which key events – neurogenesis, migration, growth, differentiation, and synaptogenesis – have to take place in an appropriate manner to ...
Christophe Porcher, Jean-Luc Gaiarsa
core   +1 more source

Chemoselective Synthesis of α‐Chloro and α,α‐Dichloro Acetamidines via the Carbenoids Addition to Inherently Low Electrophilic Carbodiimides

Advanced Synthesis &Catalysis, EarlyView.
Carbodiimides act as competent electrophilic synthons for the chemoselective addition of lithium mono‐ and di‐halocarbenoids. The transformation is provided through a single synthetic operation—hitherto elusive—halogenated acetamidines. Interestingly, the constitutively tamed electrophilicity of the starting materials is effectively counterbalanced by ...
Davide Castiglione, Margherita Miele, Alberto Nardi, Laura Castoldi, Vittorio Pace   +4 more
wiley   +1 more source

Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.

Journal of Neurophysiology, 2011
Extrasynaptic GABA(A) receptors (eGABARs) allow ambient GABA to tonically regulate neuronal excitability and are implicated as targets for ethanol and anesthetics.
P. Meera, M. Wallner, T. Otis
semanticscholar   +1 more source

Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor [PDF]

, 2011
Cys-loop receptor binding sites characteristically possess an "aromatic box," where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the ...
Ashby, Jamie A., Dougherty, Dennis A., Lummis, Sarah C. R., McGonigle, Ian   +3 more
core  

Three‐Component Synthesis of γ‐Amino Esters with α‐Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis

Advanced Synthesis &Catalysis, EarlyView.
γ‐Amino acid derivatives with an α‐quaternary center are prevalent in medicinally important compounds. A dual N‐heterocyclic carbene/photocatalytic pathway is developed for the three‐component synthesis of α, α ‐disubstituted γ‐amino esters. This methodology allows for the rapid synthesis of diverse libraries of γ‐amino esters in good yields.
Adam X. Wayment, Karl A. Scheidt
wiley   +1 more source