Results 61 to 70 of about 159,633 (311)

Oligodendroglial GABAergic Signaling: More Than Inhibition! [PDF]

, 2021
GABA is the main inhibitory neurotransmitter in the CNS acting at two distinct types of receptor: ligand-gated ionotropic GABAA receptors and G protein-coupled metabotropic GABAB receptors, thus mediating fast and slow inhibition of excitability at ...
Bai, Xianshu, Kirchhoff, Frank, Scheller, Anja   +2 more
core   +1 more source

A photoswitchable GABA receptor channel blocker [PDF]

British Journal of Pharmacology, 2019
Background and PurposeAnion‐selective Cys‐loop receptors (GABA and glycine receptors) provide the main inhibitory drive in the CNS. Both types of receptor operate via chloride‐selective ion channels, though with different kinetics, pharmacological profiles, and localization.
Franck Peiretti, Karin Rustler, Alexandre Gomila-Juaneda, Daniel Wutz, Mercedes Alfonso-Prieto, Mercedes Alfonso-Prieto, Pau Gorostiza, Alba Nin-Hill, Burkhard König, Antoni Bautista-Barrufet, Carme Rovira, Carme Rovira, Elena Petukhova, Galyna Maleeva, Petra Scholze, Piotr Bregestovski, Piotr Bregestovski   +16 more
openaire   +5 more sources

Longitudinal Relationship Between Pain and Depression in People With Inflammatory Arthritis: A Narrative Review

Arthritis Care &Research, EarlyView.
As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox, Saeed Farooq, Helen Twohig, Ian C. Scott   +3 more
wiley   +1 more source

GABA_{B} Receptors Regulate Chick Retinal Calcium Waves [PDF]

, 2001
Correlated spiking activity and associated Ca²⁺ waves in the developing retina are important in determining the connectivity of the visual system. Here, we show that GABA, via GABA_{B} receptors, regulates the temporal characteristics of Ca²⁺ waves ...
Catsicas, M, Mobbs, P
core  

GABA receptors in a state of fear [PDF]

Nature Neuroscience, 2015
Our internal states can color our memories just as powerfully as the external environment. A study finds that hippocampal GABAA receptors and associated microRNAs are important for generating state-dependent contextual fear memories.
Andrew Holmes, Alon Chen
openaire   +3 more sources

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

Advanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae, Myung‐kyu Choi, Soungyub Ahn, Gwanho Ko, Daniel T. Choe, Hyunsoo Yim, Ken C. Nguyen, Jinseop S. Kim, David H. Hall, Junho Lee   +9 more
wiley   +1 more source

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia

Molecular Pain, 2009
Background Our goal is to use gene therapy to alleviate pain by targeting glial cells. In an animal model of facial pain we tested the effect of transfecting the glutamic acid decarboxylase (GAD) gene into satellite glial cells (SGCs) of the trigeminal ...
Lowenstein Pedro, Puntel Mariana, Liu Chunyan, Maechler Pierre, Rubi Blanca, Sundberg Christopher, Ohara Peter T, Vit Jean-Philippe, Castro Maria, Jasmin Luc   +9 more
doaj   +1 more source

A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis

Advanced Science, EarlyView.
The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng, Xinyi Jing, Liuqi Shao, Yakun Wang, Congrui Fu, Hongxiao Yu, Xiaoyi Wang, Xue Zhao, Fanrao Kong, Yake Ji, Xiaochen Tian, Wei He, Shangyu Bi, Luo Shi, Hanqiao Wang, Fang Yuan, Sheng Wang   +16 more
wiley   +1 more source

Evaluating and forecasting the associated main flavor components in Baijiu (Chinese distilled spirits) with alcohol metabolism and hangover symptoms through mice acute withdrawal model

Food Science &Nutrition, Volume 11, Issue 1, Page 334-343, January 2023., 2023
Chinese distilled spirits (Baijiu) is one of the most favourite alcohol beverages. The flavor quality of Baijiu is supposed to be one of the key factors which caused the hangover. However, little systematic study has been done to estimate the flavors effects on the hangover in the different aroma‐type of Baijiu.
Jie Huangfu, Jun Lu, Changwen Li, Deliang Wang, Chunguang Luan, Xin Jiang, Tao Song, Wei Jiang, Xinlin Han, Jing Feng, Yanli Liu, Mengchao He   +11 more
wiley   +1 more source

Experimental GABA A Receptor Agonists and Allosteric Modulators for the Treatment of Focal Epilepsy

Journal of Experimental Pharmacology, 2021
Slobodan M Janković,1 Miralem Dješević,2 Snežana V Janković1 1Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 2Cardiology Department, Private Policlinic Center Eurofarm, Sarajevo, Bosnia and HercegovinaCorrespondence ...
Janković SM, Dješević M, Janković SV
doaj