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Ghrelin Receptors and Epilepsy
2014Epilepsy is a neurological disorder that affects more than 50 million people worldwide. One-third of all epilepsy patients do not respond to the antiepileptic medications that are currently available. As such, there is a great need for new, more effective drugs for the treatment of epilepsy.
Portelli, Jeanelle +3 more
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Ghrelin and ghrelin receptor inhibitors: agents in the treatment of obesity
Expert Opinion on Therapeutic Targets, 2008Current medical treatment of obesity is highly ineffective. Soon after its discovery as the endogenous ligand for the growth hormone secretagogue-receptor (GHS-R), ghrelin was shown to stimulate food intake (including in humans) and promote body weight gain and adipogenesis.This review discusses the role of the ghrelin/GHS-R pathway in energy ...
João-Bruno, Soares +2 more
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Ghrelin Receptor Modulators and Their Therapeutic Potential
Future Medicinal Chemistry, 2009Ghrelin is a peptide produced predominantly in the stomach and intestines, and is a natural growth hormone (GH) secretagogue-receptor ligand. It is able to stimulate GH release, but it also exhibits an important role in conditions related to processes regulating nutrition, body composition and growth, and heart, liver, thyroid or kidney dysfunction ...
COSTANTINO, Luca, D. Barlocco
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Changes in ghrelin and ghrelin receptor expression according to feeding status
NeuroReport, 2003Ghrelin, a newly identified gut hormone, has been implicated in the regulation of food intake and energy homeostasis. This study was undertaken to investigate changes in expression levels of stomach ghrelin as well as of ghrelin receptor in the hypothalamus and pituitary glands according to feeding state.
Min-Seon, Kim +7 more
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Diminished Endometrial Expression of Ghrelin and Ghrelin Receptor Contributes to Infertility
Reproductive Sciences, 2010The objectives were to investigate the presence, distribution and sex steroid hormone regulation of ghrelin and its receptor, growth hormone secretagogue receptor (GHSR), in human endometrium in relation to endometrial receptivity and fertility. Endometrial biopsies were obtained from women with unexplained infertility and healthy fertile volunteers ...
Lusine, Aghajanova +4 more
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Cell Biology of the Ghrelin Receptor
Journal of Neuroendocrinology, 2005AbstractGhrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS‐R1a), a G‐protein coupled receptor mainly expressed in the pituitary and hypothalamus.
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Recent Developments in Ghrelin Receptor Ligands
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Aline, Moulin +3 more
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Cellular Signalling, 2007
The dimerization properties of the ghrelin receptor (GRLN-R) and its non-signalling, naturally occurring, truncated splice variant (GHS-R1b) have been investigated in human embryonic kidney 293 cells heterologously expressing these proteins. Using the techniques of bioluminescence resonance energy transfer and co-immunoprecipitation, we detected the ...
Chu, Kit Man +6 more
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The dimerization properties of the ghrelin receptor (GRLN-R) and its non-signalling, naturally occurring, truncated splice variant (GHS-R1b) have been investigated in human embryonic kidney 293 cells heterologously expressing these proteins. Using the techniques of bioluminescence resonance energy transfer and co-immunoprecipitation, we detected the ...
Chu, Kit Man +6 more
openaire +4 more sources
Ala-scan of ghrelin (1–14): interaction with the recombinant human ghrelin receptor [PDF]
Peptides, 2004 Ghrelin, a 28 residues acylated peptide, is the natural ligand of the growth-hormone secretagogue receptor (GHS-R), which also interacts with small synthetic peptides. We investigated the importance of each of the first 14 N-terminal residues by Ala replacement (Ala-scan) and also of the N-terminal positive charge, on the recombinant GHS-R expressed in
Van Craenenbroeck, Mélanie +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Deciphering the mechanisms involved in the recognition of natural ligands by their G protein-coupled receptors (GPCRs) is a major issue in pharmacology, particularly for peptide-activated receptors, for which structural data are sparse. Here,
G. Ferré +15 more
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Significance Deciphering the mechanisms involved in the recognition of natural ligands by their G protein-coupled receptors (GPCRs) is a major issue in pharmacology, particularly for peptide-activated receptors, for which structural data are sparse. Here,
G. Ferré +15 more
semanticscholar +1 more source