Results 201 to 210 of about 2,692,169 (258)

Ghrelin Receptor Mutations and Human Obesity

2016
Growth hormone secretagogue receptor (GHSR) was originally identified as an orphan receptor in porcine and rat anterior pituitary membranes. In 1999, GHSR was deorphanized and shown to be a receptor for ghrelin, a peptide hormone secreted from the stomach. Therefore, GHSR is also called ghrelin receptor.
W, Wang, Y-X, Tao
openaire   +2 more sources

Central functions of the ghrelin receptor

2014
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism, cardiovascular performances, reproduction, memory, and immunological responses, amongst others.
Portelli, Jeanelle, Smolders, Ilse
openaire   +3 more sources

Ghrelin and the heart

Peptides, 2019
HIGHLIGHTSGhrelin, a growth hormone–releasing peptide that was first discovered in the stomach of rats.Subsequent studies have demonstrated that ghrelin is beneficial for the treatment of cardiac diseases.Beneficial effects of ghrelin are partially ...
T. Tokudome, Kentaro Otani, M. Miyazato, K. Kangawa   +3 more
semanticscholar   +1 more source

Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens

General and Comparative Endocrinology, 2006
Ghrelin, a peptide hormone produced by the stomach in mammals, stimulates growth hormone release and food intake. Recently, ghrelin was identified and characterized in chicken proventriculus and shown to stimulate growth hormone release but inhibit feed intake.
Mark P, Richards, Stephen M, Poch, John P, McMurtry   +2 more
openaire   +2 more sources

Constitutive Activity of the Ghrelin Receptor

2014
Cloning and characterization of the ghrelin receptor as a 7-transmembrane (7TM), G-protein-coupled receptor (GPCR) was first reported by Howard and his co-workers (1996). The ghrelin receptor was initially described as a growth hormone secretagogue receptor since (GHSR) this was the most well-established physiological function at that time. The natural
Jacek Mokrosiński, Andreas Nygaard Madsen, Birgitte Holst   +2 more
openaire   +1 more source

Homodimerization and Heterodimerization of the Ghrelin Receptor

2014
Ghrelin triggers different metabolic and behavioral effects. This suggests that the GHSR may act synergistically with other families of receptors. Two isoforms of GHSR have been identified, i.e., GHSR-1a and GHSR-1b. Only GHSR-1a is the active form and transduces ghrelin signal.
Alessandro Laviano, Alessia Mari
openaire   +1 more source

Ghrelin receptors mediate ghrelin‐induced excitation of agouti‐related protein/neuropeptide Y but not pro‐opiomelanocortin neurons

Journal of Neurochemistry, 2017
Shao-Rui Chen, Hong Chen, Jing-Jing Zhou, G. Pradhan, Yuxiang Sun, H. Pan, De-Pei Li   +6 more
semanticscholar   +1 more source

Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors.

Trends in endocrinology and metabolism, 2016
M. S. Engelstoft, Thue W. Schwartz
semanticscholar   +1 more source

Ghrelin induces adiposity in rodents

Nature, 2000
M. Tschöp, D. Smiley, M. Heiman
semanticscholar   +1 more source

A role for ghrelin in the central regulation of feeding

Nature, 2001
M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, S. Matsukura   +6 more
semanticscholar   +1 more source