Results 71 to 80 of about 27,278 (203)

scRiskCell: A single‐cell framework for quantifying islet risk cells and their adaptive dynamics in type 2 diabetes

iMeta, EarlyView.
scRiskCell is an interpretable intelligent computational framework that leverages nearly 500,000 islet cell expression profiles from 106 donors across different continuous disease states. By calculating the intrinsic relationship between donor disease states and cell expression profiles, it assigns a pseudo‐cell state index to each cell.
Xueqin Xie, Changchun Wu, Fuying Dao, Kejun Deng, Dan Yan, Jian Huang, Hao Lyu, Hao Lin   +7 more
wiley   +1 more source

Regulation of ghrelin receptor by microbial and inflammatory signals in human osteoblasts

Brazilian Oral Research, 2019
: Recently, it has been suggested that the anti-inflammatory hormone ghrelin (GHRL) and its receptor GHS-R may play a pivotal role in periodontal health and diseases. However, their exact regulation and effects in periodontitis are not known.
Marjan Nokhbehsaim, Andressa Vilas Boas Nogueira, Svenja Memmert, Anna Damanaki, Sigrun Eick, Joni Augusto Cirelli, James Deschner   +6 more
doaj   +1 more source

In1-ghrelin, a splice variant of ghrelin gene, is associated with the evolution and aggressiveness of human neuroendocrine tumors: Evidence from clinical, cellular and molecular parameters [PDF]

, 2015
This work has received the following grants: Proyectos de Investigación en Salud (FIS) PI13–01414, and PIE-0041 (funded by Instituto de Salud Carlos III) and S2011/BMD-2328 TIRONET (funded by Comunidad de Madrid) (to MM).
Ast, Camiña, Castano, Castano, Castaño, Castaño, Chopin, Chopin, Dayal, Dieguez, Evans, Florio, Ghigo, Goldstein, Grossman, Hale, Halperin, Herington, Kangawa, Klöppel, Kobelt, Kono, Lopez-Pedrera, Luque, Martinez-Fuentes, Muccioli, Nakamura, Oberg, Papotti, Papotti, Pisegna, Scarpa, Singh, Skogseid, Solcia, Thompson, Visser, Volante, Wiedenmann, Wiedenmann, Wise, Wise   +41 more
core   +4 more sources

Determination of Biotin Interference in Pediatric Obesity Related ELISA Research Kits Biotin Interference in Manual ELISA Kits

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we aimed for the first time to demonstrate biotin interference in ELISA research kits used in the analysis of pediatric obesity parameters other than routine testing. Our study revealed that biotin interaction may occur in manual ELISA kits and may cause erroneous test results.
Ezgi Kürkçü Kahraman, Orkide Donma, Mustafa Metin Donma, Ahsen Yılmaz, Savaş Güzel   +4 more
wiley   +1 more source

Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications

Frontiers in Endocrinology, 2013
Somatostatin is an important modulator of neurotransmission in the central nervous system and acts as a potent inhibitor of hormone and exocrine secretion and regulator of cell proliferation in the periphery.
Andreas eStengel, Yvette F. Taché
doaj   +1 more source

Effects of a two‐night hospitalization program as a specific health guidance on obesity and cardiovascular disease risk factors

Journal of General and Family Medicine, EarlyView.
Abstract Background To assess the effects of a two‐night hospitalization program conducted at our hospital as part of a domestic health guidance system. This program is designed for lifestyle modification within a health checkup framework for metabolic syndrome. Methods This is a single‐center, retrospective observational study. We reviewed the medical
Maki Okazaki, Takeshi Katsuki, Hideaki Kurata, Shinichi Tanaka, Hajime Tanaka, Toshihide Kawai   +5 more
wiley   +1 more source

The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness

Molecular Cancer, 2017
Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Daniel Hormaechea-Agulla, Manuel D. Gahete, Juan M. Jiménez-Vacas, Enrique Gómez-Gómez, Alejandro Ibáñez-Costa, Fernando L-López, Esther Rivero-Cortés, André Sarmento-Cabral, José Valero-Rosa, Julia Carrasco-Valiente, Rafael Sánchez-Sánchez, Rosa Ortega-Salas, María M. Moreno, Natia Tsomaia, Steve M. Swanson, Michael D. Culler, María J. Requena, Justo P. Castaño, Raúl M. Luque   +18 more
doaj   +1 more source

Randomized Controlled Trial: Effects of a Bitter‐Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects

Molecular Nutrition &Food Research, EarlyView.
Two pea protein hydrolysates (PPHs) reduced hunger by targeting different mechanisms: PPH1 produced a faster response in satiety and hunger hormone levels in the blood, while PPH2 had a stronger impact on gastric emptying. These effects are likely due to the differing degrees of hydrolysis between the two PPHs.
Katrin Gradl, Sonja Sterneder, Kristin Kahlenberg, Beate Brandl, Thomas Skurk, Veronika Somoza   +5 more
wiley   +1 more source

Taking Two to Tango: A Role for Ghrelin Receptor Heterodimerization in Stress and Reward

Frontiers in Neuroscience, 2013
The gut hormone, ghrelin, is the only known peripherally derived orexigenic signal. It activates its centrally expressed receptor, the growth hormone secretagogue receptor (GHS-R1a), to stimulate food intake.
Harriet eSchellekens, Timothy G Dinan, Timothy G Dinan, Timothy G Dinan, John F Cryan, John F Cryan, John F Cryan   +6 more
doaj   +1 more source

In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines [PDF]

, 2017
OXFORD UNIVERSITY: This is a pre-copyedited, author-produced version of an article accepted for publication in Carcinogenesis following peer review. The version of record David Rincón-Fernández, Michael D Culler, Natia Tsomaia, Gema Moreno-Bueno, Raúl M ...
Castaño, Justo P., Culler, Michael D., Gahete, Manuel D., Luque, Raúl M., Moreno-Bueno, Gema, Rincón-Fernández, David, Tsomaia, Natia   +6 more
core   +1 more source