Results 271 to 280 of about 45,803 (309)
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Independence of Glucagon Receptors and Glucagon Inactivation in Liver Cell Membranes
Nature New Biology, 1972THERE is increasing evidence that receptors for polypeptide hormones are localized on the cell membrane. Hormone-receptor interactions have been studied primarily by measuring the bmding of 125I-labelled hormones to intact1 or broken-cell preparations2–6.
B, Desbuquois, P, Cuatrecasas
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Glucagon and Its Receptor in Various Tissues
Annals of the New York Academy of Sciences, 2006info:eu-repo/semantics ...
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Cloning and Expression of a Human Glucagon Receptor
Biochemical and Biophysical Research Communications, 1994A human glucagon receptor has been cloned from human liver tissue. The 1578-bp cDNA clone encodes a protein of 477 amino acids with 82% identity to the rat glucagon receptor. The predicted secondary structure and homology to known proteins places this receptor within the superfamily of seven transmembrane domain G protein coupled receptors ...
D J, MacNeil +4 more
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Regulation of Rat Glucagon Receptor Expression
Biochemical and Biophysical Research Communications, 1994This report describes the isolation of a cDNA for the rat glucagon receptor by using the glucagon-like peptide 1 receptor cDNA as a probe. Northern blot analysis using the cDNA clone showed that the message encoding the receptor is approximately 2.3 kb in size and is expressed only in liver and kidney among seven tissues tested.
H, Yoo-Warren +5 more
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Regulation of the glucagon receptor by physiological hyperglucagonaemia
Nature, 1978IT is well recognised that the first step in the action of polypeptide hormones and catecholamines on target cells is binding of the hormone to a membrane receptor1. Insulin2, catecholamines3 and prolactin4 have been shown to regulate the concentration of their own receptors. For example, hyperinsulinaemia due to a variety of causes is accompanied by a
V, Soman, P, Felig
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Substituted Imidazoles as Glucagon Receptor Antagonists
Bioorganic & Medicinal Chemistry Letters, 2001A modestly active, nonselective triarylimidazole lead was optimized for binding affinity with the human glucagon receptor. This led to the identification of a 2- and/or 4-alkyl or alkyloxy substituent on the imidazole C4-aryl group as a structural determinant for significant enhancement in binding with the glucagon receptor (e.g., 41, IC(50)=0.053 ...
L L, Chang +11 more
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Annales de biologie clinique, 1977
The lecturer recalls the discovery of glucagon receptors in liver cell membranes, the role of the adenylate cyclase-AMPc system, until recent attempts at purification and isolation of this receptor. He then reviews successively, the problems of estimation, specificity of the interaction, the effects of purine and pyrimidine nucleotides on glucagon ...
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The lecturer recalls the discovery of glucagon receptors in liver cell membranes, the role of the adenylate cyclase-AMPc system, until recent attempts at purification and isolation of this receptor. He then reviews successively, the problems of estimation, specificity of the interaction, the effects of purine and pyrimidine nucleotides on glucagon ...
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Identification of Glucagon Receptors in Rat Retina
Journal of Neurochemistry, 1990Abstract:In this study, we characterize the glucagon receptors on rat retinal particulate preparations. The specific binding of 125I‐glucagon was saturable and reversible. Apparent equilibrium conditions were established within 30–45 min. Analysis of binding data is compatible with the existence of two classes of binding sites: a high‐affinity class ...
R, Fernandez-Durango +2 more
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Glucagon receptor signaling in metabolic diseases
Peptides, 2018Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels and this has recently have been ...
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The past, present, and future physiology and pharmacology of glucagon
Cell Metabolism, 2022Megan E Capozzi +2 more
exaly