Results 71 to 80 of about 45,803 (309)

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets

iScience
Summary: Glucagon is secreted by pancreatic α-cells to counteract hypoglycaemia. How glucose regulates glucagon secretion remains unclear. Here, using mouse islets, we studied the role of transmembrane and endoplasmic reticulum (ER) Ca2+ on intrinsic α ...
Samuel Acreman, Jinfang Ma, Geoffrey Denwood, Rui Gao, Andrei Tarasov, Patrik Rorsman, Quan Zhang   +6 more
doaj   +1 more source

Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors

, 1998
cAMP is required for normal glucose-induced insulin release by pancreatic beta-cells. In a previous study, we showed that cAMP production in beta-cells depends on the expression of receptors for glucagon, glucagon-like peptide 1(7-36) amide [GLP-1(7-36 ...
Schuit, Frans, Pipeleers, Daniel, Moens, Karen, Van Schravendijk, C, Ling, ZD, Flamez, Daisy   +5 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Partial purification and characterization of the glucagon receptor [PDF]

FEBS Letters, 1983
Specific labeling of liver plasma membrane glucagon receptors has been achieved by the photoincorporation of a 125I‐labeled photoderivative of glucagon, N E‐4‐azidophenylamidinoglucagon. Identification of glucagon receptors was facilitated by irradiating membranes in the presence of excess unlabeled glucagon.
Horuk, Richard, Wright, David E.
openaire   +2 more sources

Receptors of peptide hormones in the gut of rice brown planthopper (Nilaparvata lugens) as targets for novel insecticides [PDF]

, 2004
The rice brown planthopper, Nilaparvata lugens, is a pest of rice where it can be responsible for single season crop losses of up to 38% (IRRI statistic).
Price, Daniel Richard Glenfield
core  

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis [PDF]

, 2012
Background Type 2 diabetes is a risk factor for Alzheimer's disease (AD), most likely linked to an impairment of insulin signalling in the brain. Therefore, drugs that enhance insulin signalling may have therapeutic potential for AD. Liraglutide (Victoza)
Hunter, Kerry, Holscher, Christian, Hunter Kerry, Hölscher Christian, Kerry Hunter, Christian Holscher   +5 more
core   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Constitutive Activity of Glucagon Receptor Mutants [PDF]

Molecular Endocrinology, 1998
Increased constitutive activity has been observed in the PTH receptor in association with naturally occurring mutations of two residues that are conserved between members of the glucagon/vasoactive intestinal peptide/calcitonin 7TM receptor family. Here, the corresponding residues of the glucagon receptor, His178 and Thr352, were probed by mutagenesis.
Hjorth, Siv A., Ørskov, Cathrine, Schwartz, Thue W.   +2 more
openaire   +2 more sources

Glucagon-mediated Ca²⁺signaling in BHK cells expressing cloned human glucagon receptors

, 1998
From video imaging of fura 2-loaded baby hamster kidney (BHK) cells stably expressing the cloned human glucagon receptor, we found the Ca2+response to glucagon to be specific, dose dependent, synchronous, sensitive to pertussis toxin, and independent of ...
Lars H. Hansen, Pierre Bouchelouche, Laura Jelinek, Erica Nishimura, Wayne Kindsvogel, Ted Whitmore, Jesper Gromada   +6 more
core   +1 more source

Health‐Related Quality of Life, Everyday Executive Functioning, and Eating Behavior in Adults With Bardet–Biedl Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Bardet–Biedl syndrome (BBS) is a rare genetic condition with a broad phenotypic spectrum. Knowledge about quality of life, executive functioning, and eating behavior in adults with BBS remains limited. This study aimed to assess health‐related quality of life (HRQoL), everyday executive functioning, and eating behavior in adults with BBS and ...
Cecilie Fremstad Rustad, Charlotte von der Lippe, Hilde Nordgarden, Jeanette Ullmann Miller, Mina Susanne Weedon‐Fekjær, Ragnheidur Bragadottir, Solrun Sigurdardottir   +6 more
wiley   +1 more source