Results 141 to 150 of about 90,980 (312)

Glucocorticoid and sex hormone receptors: Clinical implications and therapeutic relevance

, 2007
In general, steroid hormones exert their effects through intracellular receptors, the glucocorticoid (GR), mineralocorticoid (MR), androgen (AR), estrogen (ER), and progesterone (PR) receptors.
Katsambas, Andreas, Stefanaki, Christina, Chrousos, George P.   +2 more
core  

Membrane associated synaptic mineralocorticoid and glucocorticoid receptors are rapid regulators of dendritic spines

, 2016
Unemployment is never a good situation to be in. For ~25 years the direct membrane acting, non-genomic, variety of the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) have been in want of a credible function.
Russo, Manuela F., Sarah R. Ah Loy, Ah Loy, Sarah R., Battle, Andrew R., Johnson, Luke R., Luke R. Johnson, Russo, Manuela, Manuela F. Russo, Andrew R. Battle   +8 more
core   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

The Glucocorticoid Receptor in Cardiovascular Health and Disease

, 2019
The glucocorticoid receptor is a member of the nuclear receptor family that controls many distinct gene networks, governing various aspects of development, metabolism, inflammation, and the stress response, as well as other key biological processes in ...
Jessica K. Knight, Julie E. Goodwin, Bing Liu, Tie-Ning Zhang   +3 more
core   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment

The Journal of Clinical Investigation
Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remain unclear.
Xu Li, Tongzhou Liang, Bingyang Dai, Liang Chang, Yuan Zhang, Shiwen Hu, Jiaxin Guo, Shunxiang Xu, Lizhen Zheng, Hao Yao, Hong Lian, Yu Nie, Ye Li, Xuan He, Zhi Yao, Wenxue Tong, Xinluan Wang, Dick Ho Kiu Chow, Jiankun Xu, Ling Qin   +19 more
doaj   +1 more source

Astrocytic glucocorticoid receptors in the ventral hippocampus modulate anxiety-like behaviors

Brain Research Bulletin
Stress exposure is associated with the development of anxiety disorders, and astrocytes have emerged as critical mediators of stress responses and anxiety pathogenesis.
Cheng-Lin Lu, Jing Ren, Wei Wang, Liang-Yu Chen, Xiao-Ying Lian, Xiong Cao   +5 more
doaj   +1 more source

Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors.

, 1983
Liquorice abuse causes a syndrome of pseudohyperaldosteronism. Much less commonly, glucocorticoid-like effects have been reported. The electrolyte-active principle of liquorice is glycyrrhizic acid (GI), which can be hydrolyzed to glycyrrhetinic acid (GE)
ARMANINI, DECIO, KARBOWIAK I, FUNDER J.W.   +2 more
core  

Avaliação de proteínas chaves envolvidas nas vias insulínica e inflamatória e do receptor de glicocorticoide em tecido adiposo de ratos tratados com dexametasona [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Florianópolis, 2014.É sabido que os glicocorticoides (GCs) podem diminuir a sensibilidade ...
Motta, Katia
core  

Glucocorticoid and Mineralocorticoid Receptors in the Brain: A Transcriptional Perspective

, 2019
Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)-members of the family of nuclear receptors. MRs and GRs can mediate
Weert, L.T.C.M. van, Buurstede, J.C., Meijer, O.C., Koning, A.S.C.A.M.   +3 more
core   +1 more source