Results 171 to 180 of about 2,876,830 (353)

Time‐course characterization of intraocular pressure in murine steroid‐induced ocular hypertension: Effects of route, schedule, and concentration

Animal Models and Experimental Medicine, EarlyView.
Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan, Sai Bo Bo Tun, Hla Myint Htoon, Veluchamy Amutha Barathi, Tina T. Wong   +4 more
wiley   +1 more source

A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: Studies with RU38486, a potent and selective antiglucocorticoid [PDF]

RU38486, a potent and selective antiglucocorticoid, was employed to study a possible role for endogenous glucocorticoids in atrophy of the levator ani muscle secondary to castration of male rats.
Konagaya, M., Max, S. R.
core   +1 more source

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

Immunity, 2002
R. McHugh, M. Whitters, C. Piccirillo, D. Young, E. Shevach, M. Collins, M. Byrne   +6 more
semanticscholar   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Glucocorticoid Receptor Signaling: Multilevel Organization, Roles in Fetal Development, and Postnatal Outcomes. [PDF]

Int J Mol Sci
Potapova S, Isakov Y, Tyulkova E, Vetrovoy O.   +3 more
europepmc   +1 more source

Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor

Science Signaling, 2010
T. Kino, D. Hurt, T. Ichijo, N. Nader, G. Chrousos   +4 more
semanticscholar   +1 more source

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, EarlyView.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

Distinct Effects of Maternal Stress and Exercise on Offspring Metabolic Health. [PDF]

FASEB J
Yang FT, Esteves JV, Baer LA, Pinckard KM, Verosky BG, Togliatti OA, Burkhart C, Alzuhaili SA, Seculov NP, Gur TL, Stanford KI.   +10 more
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer. [PDF]

Signal Transduct Target Ther
Chakraborty S, Pramanik J, Alviter-Raymundo G, Ward CJ, Shaji SK, Yamashita-Kanemaru Y, Ali FAZ, Banik D, Zhang Z, Veiga-Villauriz C, Homer NZM, Simpson J, Laforest S, Tong S, Zhao Q, Roy J, Iqbal M, Morris AC, Chapman MA, Roychoudhuri R, Hussein H, Klenerman D, Saeb-Parsy K, Mahata B.   +23 more
europepmc   +1 more source