Results 291 to 300 of about 2,659,590 (353)

Pharmacology and functions of metabotropic glutamate receptors.

Annual Review of Pharmacology and Toxicology, 1997
In the mid to late 1980s, studies were published that provided the first evidence for the existence of glutamate receptors that are not ligand-gated cation channels but are coupled to effector systems through GTP-binding proteins.
Conn Pj, J. Pin
semanticscholar   +1 more source

Glutamate Receptor Gating

Critical Reviews in Neurobiology, 2004
Ionotropic glutamate receptors (iGluRs) mediate the vast majority of fast excitatory synaptic transmissions within the mammalian central nervous system (CNS). As for other ion channel protein families, there has been astounding progress in recent years in elucidating the details of protein structure through the crystallization of at least part of the ...
Kevin Erreger, Philip E. Chen, Stephen F. Traynelis, David J. A. Wyllie   +3 more
openaire   +3 more sources

Glutamate Receptors in Microglia

CNS & Neurological Disorders - Drug Targets, 2013
Expression of functional glutamate receptors (GluR) on glial cells in the developing and mature brain has been recently established. Over the last decade there has been physiological, molecular and biochemical evidence suggesting the presence of GluR on microglia. However, the significance of GluR activation in microglia remains largely unknown.
Charanjit Kaur, Madhuvika Murugan, Eng-Ang Ling   +2 more
openaire   +2 more sources

Molecular diversity of glutamate receptors and implications for brain function.

Science, 1992
The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders.
S. Nakanishi
semanticscholar   +1 more source

Glutamate receptors and pain

Seminars in Cell & Developmental Biology, 2006
Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage. An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a ...
Eric S. Nisenbaum, Andrew Alt, David Bleakman   +2 more
openaire   +3 more sources

Structure of Glutamate Receptors

Current Drug Targets, 2007
Glutamate receptors mediate a vast array of processes in plants, animals and bacteria. In particular, the ionotropic glutamate receptors (iGluRs) are the most abundant excitatory neurotransmitter receptors in the mammalian central nervous system. Because these proteins are constructed from distinct folding domains, most of which can be traced to ...
Ahmed H. Ahmed, Adrienne P. Loh, Michael K. Fenwick, Robert E. Oswald   +3 more
openaire   +3 more sources

Glutamate receptors and metaplasticity in addiction

Current Opinion in Pharmacology, 2021
Chronic drug use is a neuroadaptive disorder characterized by strong and persistent plasticity in the mesocorticolimbic reward system. Long-lasting effects of drugs of abuse rely on their ability to hijack glutamate receptor activity and long-term synaptic plasticity processes like long-term potentiation and depression.
Chiamulera, Cristiano, Piva, Alessandro, Abraham, Wickliffe C   +2 more
openaire   +3 more sources

A family of AMPA-selective glutamate receptors.

Science, 1990
Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library.
K. Keinänen, W. Wisden, B. Sommer, P. Werner, A. Herb, T. Verdoorn, B. Sakmann, P. Seeburg   +7 more
semanticscholar   +1 more source

Ionotropic glutamate receptors

Current Opinion in Chemical Biology, 1999
The glutamate-binding sites of ionotropic glutamate receptors are formed from two extracellular domains of a single subunit. Conformational changes induced by agonist binding produce mechanical processes that are translated into ion gating and receptor desensitization.
openaire   +3 more sources

Oxidative stress, glutamate, and neurodegenerative disorders.

Science, 1993
There is an increasing amount of experimental evidence that oxidative stress is a causal, or at least an ancillary, factor in the neuropathology of several adult neurodegenerative disorders, as well as in stroke, trauma, and seizures.
J. Coyle, P. Puttfarcken
semanticscholar   +1 more source