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Glutamate receptor channel signatures
Trends in Pharmacological Sciences, 2001Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each ...
Sprengel, R. +5 more
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Science, 1997
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of LTP increased the phosphorus-32 labeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate ...
A. Barria +4 more
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Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of LTP increased the phosphorus-32 labeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate ...
A. Barria +4 more
semanticscholar +1 more source
Glutamate Receptors and Glutamate Corticofugal Pathways
1986Although the neurochemical anatomy of many pathways in human brain has been studied, little attention has been paid to the human pyramidal system. This pathway is very important for voluntary motor control in vertebrates, and pyramidal tract pathology leads to hemiparesis or hemiplegia in primates and man (Phillips and Porter, 1977).
Anne B. Young +3 more
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Glutamate Receptors in Taste Receptor Cells
2007Glutamate plays a double role in the physiology of TRCs. As a free-occurring component of some foodstuff, glutamate is detected by TRCs and conveys information about the presence of protein-rich source. As a substance released by TRC and/or nerve endings, it is involved in cell-to-cell communication at chemical synapses in taste organs.
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Science Signaling, 2011
Amino acid modulation of Ca 2+ signaling guides growth of plant pollen tubes.
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Amino acid modulation of Ca 2+ signaling guides growth of plant pollen tubes.
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2000
Publisher Summary Glutamate receptors come in two types: ionotropic and metabotropic. The ionotropic receptors are ligand-gated ion channels. Traditionally, ionotropic glutamate receptors have been classified according to their preferred agonists into: AMPA (a-amino-3- hydroxy-5-methyl-4-isoxazoleproprionate), kainate and NMDA (N-methyl- D-aspartate ...
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Publisher Summary Glutamate receptors come in two types: ionotropic and metabotropic. The ionotropic receptors are ligand-gated ion channels. Traditionally, ionotropic glutamate receptors have been classified according to their preferred agonists into: AMPA (a-amino-3- hydroxy-5-methyl-4-isoxazoleproprionate), kainate and NMDA (N-methyl- D-aspartate ...
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Glutamate Receptor Antagonists
Headache Currents, 2004GLUR5 Antagonists as Novel Migraine TherapiesBACKGROUND: L‐glutamate activates neurons in the trigeminal nucleus caudalis (TNC). Furthermore, non‐NMDA ionotropic glutamate receptors such as GluR5 are expressed in rat trigeminal ganglion (TG), and GluR5 receptors play an important role in central sensitization (CS).
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Metabotropic glutamate receptors and neurodegenerative diseases.
Pharmacological Research, 2017F. Ribeiro +4 more
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Chapter 24 Glutamate receptors in epilepsy
1998Glutamatergic synapses play a critical role in all epileptic phenomena. Broadly enhanced activation of post-synaptic glutamate receptors (ionotropic and metabotropic) is proconvulsant. Antagonists of NMDA receptors and AMPA receptors are powerful anticonvulsants in many animal models of epilepsy.
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