Results 11 to 20 of about 2,815,935 (309)

Role of Glycans on Key Cell Surface Receptors That Regulate Cell Proliferation and Cell Death

Cells, 2021
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated.
Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen   +3 more
doaj   +1 more source

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.

Cytokine & growth factor reviews, 2015
The four receptor tyrosine kinases (RTKs) within the family of Fibroblast Growth Factor Receptors (FGFRs) are critical for normal development but also play an enormous role in oncogenesis.
Leandro H. Gallo, Katelyn N. Nelson, A. N. Meyer, D. Donoghue   +3 more
semanticscholar   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections. [PDF]

PLoS Pathogens, 2012
A subset of human papillomavirus (HPV) infections is causally related to the development of human epithelial tumors and cancers. Like a number of pathogens, HPV entry into target cells is initiated by first binding to heparan sulfonated proteoglycan ...
Zurab Surviladze, Agnieszka Dziduszko, Michelle A Ozbun   +2 more
doaj   +1 more source

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Scientific Reports, 2020
Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 ...
Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill   +9 more
doaj   +1 more source

Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer. [PDF]

PLoS ONE, 2013
INTRODUCTION: Male breast cancer accounts for 0.5-1% of all breast cancers and is generally diagnosed at higher stage than female breast cancers and therefore might benefit from earlier detection and targeted therapy.
Jeroen F Vermeulen, Robert Kornegoor, Elsken van der Wall, Petra van der Groep, Paul J van Diest   +4 more
doaj   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

Cells, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson, Michael P. Smith, Chiara Francavilla   +2 more
doaj   +1 more source

Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1

Journal of Lipid Research, 2008
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide array of biologic effects through its interaction with a family of five G protein-coupled receptors.
Deborah A. Lebman, Sarah Spiegel
doaj   +1 more source

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

Science, 2011
A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling. The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors
Wei Tang, Yi Lu, Q. Tian, Yan Zhang, F. Guo, Guang-Yi Liu, Nabeel Muzaffar Syed, Y. Lai, E. Lin, L. Kong, Jeffrey Y. Su, F. Yin, A. Ding, A. Zanin-Zhorov, Michael Loran Dustin, J. Tao, J. Craft, Z. Yin, Jian Q. Feng, S. Abramson, Xiu-ping Yu, Chuan-ju Liu   +21 more
semanticscholar   +1 more source

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source