Results 21 to 30 of about 2,825,424 (355)

Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections. [PDF]

PLoS Pathogens, 2012
A subset of human papillomavirus (HPV) infections is causally related to the development of human epithelial tumors and cancers. Like a number of pathogens, HPV entry into target cells is initiated by first binding to heparan sulfonated proteoglycan ...
Zurab Surviladze, Agnieszka Dziduszko, Michelle A Ozbun   +2 more
doaj   +1 more source

Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer. [PDF]

PLoS ONE, 2013
INTRODUCTION: Male breast cancer accounts for 0.5-1% of all breast cancers and is generally diagnosed at higher stage than female breast cancers and therefore might benefit from earlier detection and targeted therapy.
Jeroen F Vermeulen, Robert Kornegoor, Elsken van der Wall, Petra van der Groep, Paul J van Diest   +4 more
doaj   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

Cells, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson, Michael P. Smith, Chiara Francavilla   +2 more
doaj   +1 more source

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Scientific Reports, 2020
Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 ...
Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill   +9 more
doaj   +1 more source

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Guse, Andreas H., Kessler, Ulrike, Funk, Barbara, Gercken, Günther, A. H. Guse, Kiess, Wieland   +6 more
core   +1 more source

Thematic Review Series: Sphingolipids. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling*1

Journal of Lipid Research, 2008
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that mediates a wide array of biologic effects through its interaction with a family of five G protein-coupled receptors.
Deborah A. Lebman, Sarah Spiegel
doaj   +1 more source

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

Science, 2011
A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling. The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue repair, tumorigenesis, and inflammation, but its receptors
Wei Tang, Yi Lu, Q. Tian, Yan Zhang, F. Guo, Guang-Yi Liu, Nabeel Muzaffar Syed, Y. Lai, E. Lin, L. Kong, Jeffrey Y. Su, F. Yin, A. Ding, A. Zanin-Zhorov, Michael Loran Dustin, J. Tao, J. Craft, Z. Yin, Jian Q. Feng, S. Abramson, Xiu-ping Yu, Chuan-ju Liu   +21 more
semanticscholar   +1 more source

Microvascularization and Expression of Fibroblast Growth Factor and Vascular Endothelial Growth Factor and Their Receptors in the Mare Oviduct

Animals, 2021
The oviduct presents the ideal conditions for fertilization and early embryonic development. In this study, (i) vascularization pattern; (ii) microvascular density; (iii) transcripts of angiogenic factors (FGF1, FGF2, VEGF) and their receptors—FGFR1 ...
Pedro Pinto-Bravo, Maria Rosa Rebordão, Ana Amaral, Carina Fernandes, António Galvão, Elisabete Silva, Pedro Pessa-Santos, Graça Alexandre-Pires, Rosário P. Roberto da Costa, Dariusz J. Skarzynski, Graça Ferreira-Dias   +10 more
doaj   +1 more source

BRET biosensor analysis of receptor tyrosine kinase functionality

Frontiers in Endocrinology, 2013
Bioluminescence resonance energy transfer (BRET) is an improved version of earlier resonance energy transfer technologies used for the analysis of biomolecular protein interaction.
Sana eSiddiqui, Wei-na eCong, Caitlin M Daimon, Bronwen eMartin, Stuart eMaudsley   +4 more
doaj   +1 more source

The Fibroblast Growth Factor Signaling Pathway

Wiley Interdisciplinary Reviews: Developmental Biology, 2015
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs).
D. Ornitz, N. Itoh
semanticscholar   +1 more source